(v. t.) To cause to sound, as a bell, with strokes slowly and uniformly repeated; as, to toll the funeral bell.
(v. t.) To strike, or to indicate by striking, as the hour; to ring a toll for; as, to toll a departed friend.
(v. t.) To call, summon, or notify, by tolling or ringing.
(v. i.) To sound or ring, as a bell, with strokes uniformly repeated at intervals, as at funerals, or in calling assemblies, or to announce the death of a person.
(n.) The sound of a bell produced by strokes slowly and uniformly repeated.
(n.) A tax paid for some liberty or privilege, particularly for the privilege of passing over a bridge or on a highway, or for that of vending goods in a fair, market, or the like.
(n.) A liberty to buy and sell within the bounds of a manor.
(n.) A portion of grain taken by a miller as a compensation for grinding.
(v. i.) To pay toll or tallage.
(v. i.) To take toll; to raise a tax.
(v. t.) To collect, as a toll.
Example Sentences:
(1) This death toll represents 25% of avoidable adult deaths in developing countries.
(2) Large price cuts seem to have taken a toll on retailer profitability, while not necessarily increasing sales substantially,” Barclaycard concluded.
(3) But sanctions and mismanagement took their toll, and the scale of the long-awaited economic catharsis won’t be grand,” he says.
(4) The number of killings in Iraq has reached levels unseen since 2008 in recent months and Sunday's attacks bring the death toll across the country in October to 545, according to an Associated Press count.
(5) I came from a strong family and my parents had a devoted marriage, but I experienced the toll breast cancer took on their relationship and their children.
(6) AP reported a lower death toll of one killed and 20 wounded.
(7) As BHP’s share price in Australia pushed near 10-year lows on Thursday, the government in Brasilia has become increasingly concerned over the rising death toll and contaminated mud flowing through two states as a result of the disaster.
(8) Chinese authorities have raised the death toll from Beijing's floods to 77 from 37 after the public questioned the days-old tally.
(9) Undoubtedly, as repeatedly urged, appropriate selective screening and health education could effectively reduce the toll of mortality, especially in high-risk developing populations.
(10) In fact the UN estimates the total death toll, regardless of responsibility, to be about 93,000 people.
(11) Nancy Curtin, the chief investment officer of Close Brothers Asset Management said: "The US economy didn't just grind to a halt in the first quarter – it hit reverse as the polar vortex took its toll.
(12) The lesson for the international community, fatigued or bored by competing stories of Middle Eastern carnage, is that problems that are left to fester only get worse – and always take a terrible human toll.
(13) The combined mortality and morbidity from aneurysmal subarachnoid hemorrhage exceeds 40%, and therefore yields a remarkably high toll of human and economic loss.
(14) And at the coalface of Israeli coalition management, where every deal is done over the still-twitching body of an ally fervently opposed to it, the economics of disappointment eventually take a toll.
(15) Murdoch's British newspapers, which include the Times, the Sun and the News of the World, suffered a 14% drop in year-end advertising revenue as the recession took its toll.
(16) But it had already taken its toll on the Deghayes's children.
(17) The death toll was expected to rise sharply and 20,000 civilians were sheltering in two UN bases in Juba.
(18) The death toll in Gaza has climbed to at least 480, with more than 2,300 wounded, according to Palestinian medical officials.
(19) The devastating toll it has had on this generation of children is far-reaching.
(20) The feeling of restlessness and fatigue started to take its toll and I spent more and more time alone.
Tolyl
Definition:
(n.) The hydrocarbon radical, CH3.C6H4, regarded as characteristic of certain compounds of the aromatic series related to toluene; as, tolyl carbinol.
Example Sentences:
(1) Recently, we reported the characterization of a selective sigma receptor ligand, 1,3-di-o-tolyl-guanidine (DTG), that shows negligible crossreactivity with phencyclidine receptors.
(2) The inhibition of 1,3-[3H]di(2-tolyl)guanidine binding to the sigma 2 receptor by these cations differed qualitatively and quantitatively from their effects on (+)-[3H]pentazocine binding.
(3) Compounds (+)-1, (-)-1, (-)-2, and (+)-2 were compared for their binding affinities at kappa opioid, sigma, D2-dopamine, and phencyclidine (PCP) receptors in competitive binding assays using [3H]bremazocine ([3H]BREM) or [3H]U69,593, [3H]-(+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [[3H]-(+)-3-PPP], or [3H]-1,3-di(o-tolyl)guanidine ([3H]DTG), [3H]-(-)-sulpiride [[3H]-(-)SULP], and [3H]-1- [1-(2-thienyl)cyclohexyl]piperidine ([3H]TCP), respectively.
(4) Five of these workers were clinically hypersensitive to TDI and displayed significant titers of tolyl-specific IgE antibodies in their sera.
(5) Independent immunoenzymatic and radioimmunoassay techniques indicated the absence of tolyl-specific IgG antibodies in sera from 25 workers with long-term exposure to toluene diisocyanate (TDI).
(6) To compare the actions of prototypic drugs which are selective for phencyclidine and sigma receptors, the electrophysiological effects of phencyclidine (PCP),3-[3-hydroxyphenyl]-N-(1-propyl)piperidine [+)3-PPP), and 1,3-di(2-tolyl)guanidine (DTG) on CA1 hippocampal pyramidal neurons were examined.
(7) The prostaglandin-blocking activity of meclofenamic acid, N-(2,6-dichloro-m-tolyl)anthranilic acid (CI-583), was analysed in the anaesthetized rabbit.
(8) In the present investigation, the effects of sigma ligands [WY-47384 [8-fluoro-2,3,4,5-tetrahydro-2[3-(3-pyridinyl)propyl)1H- pyrido(4,3b)indole], (+)-pentazocine, (+)-SFK 10,047 (N-allylnormetazocine), mafoprazine, opipramol, dextromethorphan, dextrorphan, (+)-3-PPP [3-(3-hydroxyphenyl)-N-propylpiperidine], (-)-butaclamol, DTG [1,3-di(2-tolyl)guanidine], rimcazole, ifenprodil and BMY-14802 [alpha-(fluorophenyl)-4-(5-fluoropyrimidinyl)-1-piperazine butanol]] on harmaline-, pentylenetetrazol (PTZ)-, methamphetamine (MA)- and D-serine-induced increases in mouse cerebellar levels of cGMP were determined.
(9) We report here the synthesis and characterization of a tritiated, symmetrically substituted guanidine derivative, 1,3-di(2-[5-3H]tolyl)guanidine ([3H]Tol2Gdn), that binds with high affinity to a single population of binding sites in guinea pig brain membrane preparations.
(10) N-[alpha-phenyl-beta-(p-tolyl)ethyl]glutaric acid monoamide were detected in the urine of rats dosed orally with 14C-PTLA.
(11) Recent studies have provided evidence that formamidine pesticides, such as chlordimeform (CDM; N'-4-chloro-o-tolyl-N,N-dimethylformamidine) or amitraz (AMZ; N'-2-4-(dimethylphenyl)-N-[((2,4-dimethylphenyl)imino)methyl]-N- methanimidamide) exert some of their toxic effects by an interaction with alpha 2-adrenoceptors.
(12) Three minor metabolites in descending order of importance were 2-hydroxymethyl-3-o-tolyl-4(3H)-quinazolinone, 2-methyl-6-hydroxy-3-o-tolyl-4(3H)-quinazolinone and 2-methyl-8-hydroxy-3-o-tolyl-4(3H)-quinazolinone.
(13) Absorption, distribution, excretion and metabolism of (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl][14C]linoleamide (14C-PTLA) were studied in rats and dogs.
(14) However, only in the NC RAST did antibodies from both patients react with p-tolyl isocyanate inhibitor.
(15) The result of laboratory experiments with fenthion, disulfoton, Kitazin P (0,0-diisopropyl S-benzyl phosphorothiolate), edifenphos (0-ethyl S,S-diphenyl phosphorodithiolate) and amiprophos (0-ethyl 0-(2-nitro-p-tolyl) N-isopropyl phosphoramidothionate) suggested the participation of several factors mentioned above in the degradation of organophosphorus pesticides.
(16) The solubility and dissolution rate of five different solid forms of 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-o-tolyl-6-quinazoline-sulfonamide (metolazone) in n-butanol, water and 0.01 n HCl are investigated and thermodynamic values have been computed.
(17) Prior inhibition of APAP deacetylation by the carboxylesterase inhibitors bis(p-nitrophenyl) phosphate or tri-o-tolyl-phosphate did not alter APAP hepatotoxicity or nephrotoxicity.
(18) The major metabolite in mice, rats, guinea-pigs and rabbits was the product of hydroxylation of the tolyl ring, which was excreted as such as the glucuronide and sulphate conjugates.
(19) We tested the effects of the liver microsomal monooxygenase inhibitor SKF 525-A (Proadifen), and other P-450 substrates on the binding of [3H]dextromethorphan, [3H]3-(-3-Hydroxyphenyl)-N-(1-propyl)piperidine and (+)-[3H]1,3-Di-o-tolyl-guanidine ([3H]DTG) to the guinea pig brain.
(20) Among the tested new antihistaminic drugs (quinuclidine derivatives) quinuclidyl-3-(O-tolyl) carbinol possessed histamine releasing action (HRA) on the isolated rat mast cells.