(superl.) Having the quality of flexibility without brittleness; yielding to force without breaking; capable of resisting great strain; as, the ligaments of animals are remarkably tough.
(superl.) Not easily broken; able to endure hardship; firm; strong; as, tough sinews.
(superl.) Not easily separated; viscous; clammy; tenacious; as, tough phlegm.
(superl.) Stiff; rigid; not flexible; stubborn; as, a tough bow.
(superl.) Severe; violent; as, a tough storm.
Example Sentences:
(1) Photograph: Guardian The research also compiled data covered by a wider definition of tax haven, including onshore jurisdictions such as the US state of Delaware – accused by the Cayman islands of playing "faster and looser" even than offshore jurisdictions – and the Republic of Ireland, which has come under sustained pressure from other EU states to reform its own low-tax, light-tough, regulatory environment.
(2) Nick Robins, head of the Climate Change Centre at HSBC, said: "If you think about low-carbon energy only in terms of carbon, then things look tough [in terms of not using coal].
(3) A series of hierarchical multiple regressions revealed the effects of Surgency, Agreeableness, Conscientiousness, Emotional Stability, and Intellect on evoking upset in spouses through condescension (e.g., treating spouse as stupid or inferior), possessiveness (demanding too much time and attention), abuse (slapping spouse), unfaithfulness (having sex with others), inconsiderateness (leaving toilet seat up), moodiness (crying a lot), alcohol abuse (drinking too much alcohol), emotional constriction (hiding emotions to act tough), and self-centeredness (acting selfishly).
(4) A lfred Ekpenyong knows first hand how tough it can be to find a secure foothold in mainstream society after leaving prison.
(5) The texture of a food item can be distinguished in hardness, toughness, stickiness, juiciness and chewability.
(6) Even as the Obama administration moves to deal with some of Guantánamo's most notorious captives, it faces tough challenges to closing the facility.
(7) "It's a tough group but other groups are also tough.
(8) This allowed it to claim that it was becoming more professional, tough minded and responsible.
(9) The austerity programmes administered by western governments in the wake of the 2008 global financial crisis were, of course, intended as a remedy, a tough but necessary course of treatment to relieve the symptoms of debts and deficits and to cure recession.
(10) And he pleased the audience with an acknowledgement that social work is a tough job and social workers only human.
(11) Trade unions have sought to highlight the insecurity of workers who have been forced into self-employment in the tough jobs market of recent years.
(12) UK negotiatiors, though, fought back hard -- thus Cameron's fighting talk in his press conference ( see 12.46pm ) 12.49pm BST Open Europe tweets Cameron's tough talk on the rebate: Open Europe (@OpenEurope) Cameron: in Feb we reached a clear deal rebate would remain unchanged, since then some have tried to question this agreement June 28, 2013 Open Europe (@OpenEurope) Cameron: I defeated these attempts to change the rebate, it will remain unchanged for this long term budget June 28, 2013 12.46pm BST David Cameron press conference underway In Brussels, David Cameron is holding his press conference now.
(13) The mechanical properties of compressed beam specimens of microcrystalline cellulose (Avicel pH 101) have been assessed in terms of the tensile strength (sigma t), Young's modulus (E) and the following fracture mechanics parameters: the critical stress intensity factor (KIC), the critical strain energy release rate (GIC) and the fracture toughness (R).
(14) "2013 was a tough year for us both in minerals and in oil and gas," Cochrane said, adding that the group had relied on"self help", including diversification which offset some of the challenges in its core mining market, improving operational efficiency, and strong growth in its after sales business, where orders were up 16% on 2012 and which accounted for 63% of revenues last year.
(15) "We carved out a few chances, but it was tough to break them down."
(16) Channel 5 will be hoping for a similar return for its new series, although with the launch audience around a third down on last year's opener, it may prove a tough ask.
(17) Dimon, the charismatic leader of the bank, had enjoyed a reputation as a tough, strict taskmaster, the kind of CEO every bank should have.
(18) Cameron put all of his betting chips on what seemed to be the party's trump card: the "vote for us, we're tough on migration and tough on migrants" strategy.
(19) As well as limited terms for MPs, Grillo has called for a referendum on the euro and a tough line on immigration.
(20) "It's a tough game but our best football has come in this competition and we'll try and show it next week.
Trough
Definition:
(n.) A long, hollow vessel, generally for holding water or other liquid, especially one formed by excavating a log longitudinally on one side; a long tray; also, a wooden channel for conveying water, as to a mill wheel.
(n.) Any channel, receptacle, or depression, of a long and narrow shape; as, trough between two ridges, etc.
Example Sentences:
(1) These observations were confirmed by the killing curves in pooled serum obtained at peak and trough levels.
(2) Plasma aldosterone peaked (p < 0.05) at 22 hours after operation, and argine vasopressin peaked (p < 0.05) at two hours and then declined (p < 0.05) to a trough at 24 hours.
(3) Our observations demonstrated that echographic coaptation of the aortic valve leaflets coincides with the trough of the aortic pressure incisura and the onset of A2.
(4) The goal of the expedition, led by Prof Ken Takai of the Japan Agency for Marine-Earth Science and Technology, was to study the limits of life at deep-sea vents in the Cayman Trough as part of a round-the-world voyage of discovery by the research ship RV Yokosuka .
(5) IDDM in Canterbury, New Zealand, presents in cycles of incidence peaks and troughs, each spanning 2-3 yr.
(6) No IgE circadian rhythm was validated in healthy children while a large amplitude (approximately equal to 30% of the 24 hours mean) circadian rhythm with 2 diurnal peaks and a nocturnal trough was demonstrated (P less than 0.0023) in the asthmatics.
(7) Trough levels of LH, however, are dependent on the frequency of LHRH-induced pulsatile LH secretion.
(8) Appropriate conditions for administering the drug by intravenous drip infusion to neonates and infants at ages of more than 1 week were investigated taking observed blood levels and achieved peak levels and trough levels calculated using the one-compartment open model into account.
(9) Dose limiting toxicities were observed in 9 of 10 patients with 12-h trough piritrexim concentrations greater than 0.5 microM, whereas only 2 of 7 patients with trough concentrations less than 0.5 microM experienced dose limiting toxicities.
(10) Both free and luciferase-bound B show similar negative circular dichroism in the region 330-475 nm with troughs at 375 and 380 nm, respectively.
(11) Whole blood steady-state trough concentrations of cyclosporine were measured by radioimmunoassay (RIA) and TDx assays employing monoclonal antibodies in 82 samples from 39 renal transplant patients.
(12) Regression analysis also showed a strong relationship between the area under the curve (AUC) from time 0 to 11 hours after the initial dose and the trough at steady state (r = 0.86).
(13) algebraic sum of these three cosine functions yielded a circadian waveform with peak-times occurring near 0300 and 1130 hr and a trough-time about 2200 hr.
(14) Group I represented the modified "over-the-top" technique with a deep cancellous bone trough and represented the most isometric tracking.
(15) Circular dichroic spectra of the lipophorins and apolipophorin from 190 to 250 nm showed a single trough at 218 nm and a peak at 194 nm.
(16) • The best ideas are tested by their peaks and troughs.
(17) During the estrous cycle, mitotic activity of the granulosa cells was highest at estrus in follicles less than 601 micron, and at diestrus in follicles greater than 600 micron; while the mitotic trough was at proestrus in all the follicles.
(18) Data analysis revealed a seasonal pattern in the monthly distribution of births, with the peak period observed during April-June, and a trough during November-January.
(19) The issues in CsA monitoring include selection of sample matrix, analytical method, dosing interval and the timing of trough measurements, the temporal relationship between measurements and physiological events such as toxicity, the concurrent presence of multiple other immunosuppressive agents, and the lack of "gold standards" for determining rejection, adequate immunosuppression, and toxicity.
(20) The addition of LTB4 to the microsomal fraction gave a type-I spectral change with a peak at around 390 nm and a trough at 422 nm, indicating a direct interaction of LTB4 with the cytochrome P-450.