(a.) Not favorable; not propitious; adverse; contrary; discouraging.
Example Sentences:
(1) Recently reported unfavorable clinical results (i.e., a high incidence of pain) have led to the discontinuation of one trial of porous polyethylene.
(2) By treatment of mice with anticancer agent CY or gamma ray irradiation, unfavorable side effects usually occurred to impair hematopoietic organs, causing bone marrow disorder.
(3) From the previously observed results of preferential interactions for salting-out salts with proteins, it was shown that the free energy of the protein is increased by addition of the salts and this unfavorable free energy is smaller for the proteins bound to the columns because of their smaller surface area exposed to solvent; i.e., the bound form of the proteins is thermodynamically more stable.
(4) Fifty percent of patients with the myelodysplastic syndrome, frequently following treatment by radiation or chemotherapy, have prognostically unfavorable deletions of the long arms of chromosomes 5 and 7, or trisomy 8, as have the 25% of patients with acute myeloblastic leukemia where remissions last 6-12 months, and where relapse cannot be prevented.
(5) Since liver metastases are the most common unfavorable outcome of colon cancer, ongoing trials using liver-directed treatment (perfusion, irradiation) should be followed with interest.
(6) Extracorporeal shockwave lithothripsy was very helpful in facilitating extraction of stones in unfavorable locations or located above the severe stricture.
(7) A positive deltaS compensates for an unfavorable positive deltaH so that the overall reaction is exergonic.
(8) The results show that conversion of Glu-208 to Gln greatly enhanced substrate binding, implying that Glu-208 interacts unfavorably with the substrate's ground state, preventing its optimal fit to the active site.
(9) Our data suggest that prostaglandin gel cervical ripening and induction of labor and delivery by 42 weeks' gestation may be the most appropriate management for patients with well-established gestational age and an unfavorable cervical examination.
(10) When patients with and without ST shift on Holter monitor ECG were compared, an unfavorable outcome was found in 48% versus 20% (p less than 0.005), multivessel disease in 76% versus 54% (p less than 0.01) and left main coronary stenosis in 18% versus 4% (p less than 0.05).
(11) Based on a preliminary trial that suggested that CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and PVB (cisplatinum, vinblastine, bleomycin), are at least partially non-cross-resistant, the Southwest Oncology Group treated patients with unfavorable histology, non-Hodgkin's lymphoma with CHOP and PVB.
(12) Myocardial transformation, along with its energy economizing effect, failed to compensate for unfavorable energetic consequences of structural dilatation and therefore the reduced ventricular efficiency is assumed to be another deleterious factor in the dilated failing heart.
(13) So far we believe that loss of hearing caused during these operations is mainly due to the unfavorable location of the cochlear blood supply through the meatus.
(14) Hypodiploidy is therefore an unfavorable karyotypic feature in childhood ALL.
(15) Hormone therapy was not indicated in these cases as it could lead to unfavorable results: decreased indices of definitive growth resulting from the formation of antibodies to the growth hormone.
(16) The course of gonarthrosis was unfavorable in that a majority of the cases became worse over the years and some also developed pain at rest.
(17) The favorable effects of up to 25% toasted soybean meal and 3% licorice root extract on the levels of the four enzymes, without unfavorable changes in clinical parameters, might account in part for the chemopreventive activities of these additives.
(18) The following signs in the preoperative radiographs were predictive of unfavorable outcome: small head fragment, comminution of the calcar femorale, and varus angulation of the head.
(19) When Rappaport's classification was used, division of unfavorable histologies into histiocytic and non-histiocytic groups provided only marginal significance in MVA.
(20) The outcome was unfavorable and the response to anticonvulsant drugs was poor.
Unwholesome
Definition:
Example Sentences:
(1) That we demand a contest as satisfyingly unwholesome and rancorous as Cain and Abel, not something as nauseatingly wholesome and harmonious as Abel and Cole?
(2) In the southern forest areas, dried fish, groundnuts and oil palm products often carry unwholesome quantities of aflatoxin.
(3) In that sense all stories are written backwards - they are supposed to begin with the facts and develop from there, but in reality they begin with a journalist's point of view, a conception... All this is difficult and even rather unwholesome to explain to the layman, because he gets the impression that you are saying that truth does not matter and that you are publicly admitting what he long ago suspected, that journalism is a way of 'cooking' the facts.
(4) Clinicians must evaluate these systems as to their wholesome or unwholesome impact on a particular health issue or problem, seeking corrective as well as preventive measures.
(5) Like other unwholesome aspects of the Anthropocene, we mostly respond to mass extinction with stuplimity: the aesthetic experience in which astonishment is united with boredom, such that we overload on anxiety to the point of outrage-outage.
(6) The influence can be strong in lasting relationships; it can be either wholesome or unwholesome.