(a.) Not favorable; not propitious; adverse; contrary; discouraging.
Example Sentences:
(1) Recently reported unfavorable clinical results (i.e., a high incidence of pain) have led to the discontinuation of one trial of porous polyethylene.
(2) By treatment of mice with anticancer agent CY or gamma ray irradiation, unfavorable side effects usually occurred to impair hematopoietic organs, causing bone marrow disorder.
(3) From the previously observed results of preferential interactions for salting-out salts with proteins, it was shown that the free energy of the protein is increased by addition of the salts and this unfavorable free energy is smaller for the proteins bound to the columns because of their smaller surface area exposed to solvent; i.e., the bound form of the proteins is thermodynamically more stable.
(4) Fifty percent of patients with the myelodysplastic syndrome, frequently following treatment by radiation or chemotherapy, have prognostically unfavorable deletions of the long arms of chromosomes 5 and 7, or trisomy 8, as have the 25% of patients with acute myeloblastic leukemia where remissions last 6-12 months, and where relapse cannot be prevented.
(5) Since liver metastases are the most common unfavorable outcome of colon cancer, ongoing trials using liver-directed treatment (perfusion, irradiation) should be followed with interest.
(6) Extracorporeal shockwave lithothripsy was very helpful in facilitating extraction of stones in unfavorable locations or located above the severe stricture.
(7) A positive deltaS compensates for an unfavorable positive deltaH so that the overall reaction is exergonic.
(8) The results show that conversion of Glu-208 to Gln greatly enhanced substrate binding, implying that Glu-208 interacts unfavorably with the substrate's ground state, preventing its optimal fit to the active site.
(9) Our data suggest that prostaglandin gel cervical ripening and induction of labor and delivery by 42 weeks' gestation may be the most appropriate management for patients with well-established gestational age and an unfavorable cervical examination.
(10) When patients with and without ST shift on Holter monitor ECG were compared, an unfavorable outcome was found in 48% versus 20% (p less than 0.005), multivessel disease in 76% versus 54% (p less than 0.01) and left main coronary stenosis in 18% versus 4% (p less than 0.05).
(11) Based on a preliminary trial that suggested that CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and PVB (cisplatinum, vinblastine, bleomycin), are at least partially non-cross-resistant, the Southwest Oncology Group treated patients with unfavorable histology, non-Hodgkin's lymphoma with CHOP and PVB.
(12) Myocardial transformation, along with its energy economizing effect, failed to compensate for unfavorable energetic consequences of structural dilatation and therefore the reduced ventricular efficiency is assumed to be another deleterious factor in the dilated failing heart.
(13) So far we believe that loss of hearing caused during these operations is mainly due to the unfavorable location of the cochlear blood supply through the meatus.
(14) Hypodiploidy is therefore an unfavorable karyotypic feature in childhood ALL.
(15) Hormone therapy was not indicated in these cases as it could lead to unfavorable results: decreased indices of definitive growth resulting from the formation of antibodies to the growth hormone.
(16) The course of gonarthrosis was unfavorable in that a majority of the cases became worse over the years and some also developed pain at rest.
(17) The favorable effects of up to 25% toasted soybean meal and 3% licorice root extract on the levels of the four enzymes, without unfavorable changes in clinical parameters, might account in part for the chemopreventive activities of these additives.
(18) The following signs in the preoperative radiographs were predictive of unfavorable outcome: small head fragment, comminution of the calcar femorale, and varus angulation of the head.
(19) When Rappaport's classification was used, division of unfavorable histologies into histiocytic and non-histiocytic groups provided only marginal significance in MVA.
(20) The outcome was unfavorable and the response to anticonvulsant drugs was poor.
Worst
Definition:
(a.) Bad, evil, or pernicious, in the highest degree, whether in a physical or moral sense. See Worse.
(n.) That which is most bad or evil; the most severe, pernicious, calamitous, or wicked state or degree.
(a.) To gain advantage over, in contest or competition; to get the better of; to defeat; to overthrow; to discomfit.
(v. i.) To grow worse; to deteriorate.
Example Sentences:
(1) For viewers in the US, you get the worst possible in-game managerial interview in Mike Matheny, one that's so bad, it's actually great!
(2) Given Australia’s number one position as the worst carbon emitter per capita among major western nations it seems hardly surprising that islanders from Fiji, Samoa, Vanuatu and other small island developing states have been turning to Australia with growing exasperation demanding the country demonstrate an appropriate response and responsibility.
(3) Tepco has taken on a US consultant, Lake Barrett , who led the NRC's cleanup of Three Mile Island, the worst commercial nuclear power accident in the nation's history.
(4) Contrary to previous reports, approximately 20% of the neurons in V3 were color selective in terms of showing a severalfold greater response to the best monochromatic wavelength compared with the worst.
(5) From comparative in vitro tests in air, fat, water, and saline it was concluded that only tests in fat or air represent the worst case condition after implantation.
(6) The ABI figures revealed that the best annuity for someone who is a heavy smoker and has severely impaired health was at Prudential, which paid out 46% more than the worst, from Friends Life.
(7) But he lost much of his earnings betting on cards and horses, and he has readily admitted that it was losses of up to £750,000 a night that compelled him to make some of his worst films.
(8) Serial measurements of proximal interphalangeal joint circumference using a single joint that was selected as being 'worst' on clinical grounds or the largest joint at baseline were compared with the mean of all 10 joints in patients with active rheumatoid arthritis receiving second-line drugs.
(9) Not that I would ever accept it, but because in doing so they've exposed themselves as the worst kind of tabloid.
(10) For both the single- and multiple-band signals, performance was best when the signal band(s) had a different envelope from the common envelope of the cue bands, and performance was worst when either the cue bands all had different envelopes, or the signal and cue bands all shared the same envelope.
(11) It will be only a matter of time before the body-count begins.” Jeremy Hunt says five-day doctors' strike will be 'worst in NHS history' Read more The BMA says it will call off the strikes if the government abandons imposing a tougher new contract in October, but the health secretary, Jeremy Hunt , was in a no-turning-back mood on the BBC’s Today programme this morning.
(12) The poor weather is coming at the worst possible time for retailers.
(13) For now, it is a hypothetical danger and England cannot be doing too badly if the worst controversy about Hodgson's squad is who goes as reserve left-back.
(14) This is no doubt a captain’s pick by Malcolm Turnbull and we hope for the sake of the relationship that it has been a good pick.” The planned appointment of Hockey to the Washington role has been one of the worst-kept secrets in Australian politics .
(15) Worst case results yielded a 5.8 degrees C surface temperature elevation, suggesting that thermally induced damage is unlikely.
(16) The accident on 10 April 2010, killed the president, first lady and dozens of senior officials, in the worst Polish air disaster since the second world war.
(17) Share your experiences Read more Last month, Delhi’s 20 million people suffered through the worst smog episode in 17 years, according to the Centre for Science and Environment.
(18) "If Germans start spending more, Germany could start importing more from the periphery [worst hit by the debt crisis]," he said.
(19) He thought that “it wasn’t [Trump]’s worst debate but it wasn’t his best”.
(20) Romanians making Polish wages go down.” Then he adds: “The Romanian, he not the worst.