(adv. & conj.) For which reason; so; -- used relatively.
(adv. & conj.) For what reason; why; -- used interrogatively.
(n.) the reason why.
Example Sentences:
(1) Treatment proved effective wherefore the authors hope that further studies will be carried out in order to increase our knowledge of the modulation and regulation of the immune response, a primary element in the management of these disorders which is at present only experimental.
(2) All the whys and wherefores are discussed and some conclusions reached.
(3) It argues that too little attention has been paid to the how and why, the what and the wherefore of evaluation.
(4) The one that never did me the courtesy of explaining the whys and wherefores.
(5) Coral graveyard: the aftermath of bleaching on the Great Barrier Reef – in pictures Read more I am struggling to get my head around the whys and wherefores of the complacency and lack of logical reasoning on this issue.
(6) Phenotypic characteristics that could differentiate between the two main DNA relatedness groups of F. meningosepticum were not discovered, wherefore a subdivision of the present species into two species cannot be recommended.
(7) 9 patients did not show a clear restriction of the clearance, wherefore in these cases a control examination was not necessary.
(8) People complain that there are no laughs in the Bible (actually Sarah, the wife of Abraham, fails to conceal her amusement when she's told that she's about to conceive, at the age of 90: "Therefore Sarah laughed within herself… And the Lord said unto Abraham, Wherefore did Sara laugh…"), but let the rabbis loose on it, and it's practically standup material.
(9) Whatever the whys and wherefores, the bottom line is that he was dropped for the glamour tie against Bayern and it would have hurt, particularly as his replacement was the untested 21-year-old Yaya Sanogo.
(10) With the help of the isotope renography could be proved that the treatment with alpha-methyldopa causes no reduction of the blood supply of the kidneys, wherefore alpha-methyldopa can be successfully applied in patients with hypertension and renal failure.
(11) Anderson said recently that the whys and wherefores of the Golden Fang aren’t important; it’s a metaphor for the Man, the system, the evil empire, whatever anti-fun military-industrial complex rules the day.
(12) Till now there is no coherent idea about their pathogenesis, wherefore in the individual case wide differences exist in the diagnosis, treatment and in the expert opinion.
(13) The clinical estimation of the "Debris Layer" forming in the course of expanding the root channel is not entirely uniform in the literature wherefore also the question of its removal is the subject of dispute.
Whereupon
Definition:
(adv.) Upon which; in consequence of which; after which.
Example Sentences:
(1) The animals were killed after an abstinence of 4 weeks, whereupon the concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) were determined in the frontal cortex.
(2) Whereupon Madonna's PR guy Trevor Neilson (who doesn't seem to be too great at his job judging by the way in which a routine baby-hugging photo-op has descended into a hilarious international shitshow) hit back, giving quotes to The Globe and Mail reporter Geoffrey York.
(3) The hormone-receptor complexes are then translocated to the nucleus, in an "activated" form, whereupon they are bound to the target cell genome.
(4) Thresholds for the response are near 0.05 mA and the stimulus intensity curve is linear to 0.4 mA whereupon the pressure rise and tachycardia begin to approach a plateau value.
(5) In three patients, carbamazepine was withdrawn, whereupon the deposits disappeared in two and decreased in the third, who changed to another drug.
(6) The first of them came after 90 seconds, when, taking a free kick from the edge of the penalty box, his feint drew Johnston aside in the wall, whereupon Hidegkuti shot through the gap, to beat Gil Merrick, an erratic keeper that day.
(7) After observing a couple of weeks of bickering over who would get what time, we threatened to remove them again, whereupon the boys negotiated with each other and came up with an equitable time-sharing agreement.
(8) The scheme is as follows; phosphatidylcholine associated with high density lipoproteins exchanges with the erythrocyte membrane phospholipids, the neutral phospholipids undergo two dimensional translational and rotational motion and also flip between each layer of the bilayer thus becoming exposed to an intracellularly-located phospholipase-D, whereupon the choline is hydrolysed and released into the intracellular milieu.
(9) Nitrogen balances were not significantly different unless analysis of covariance was used to adjust for the nitrogen intakes, whereupon all treatment groups showed improved balance, especially the animals treated with the low IGF-I dose and des(1-3)IGF-I (both P less than 0.01).
(10) The ether phospholipid platelet-activating factor (PAF) has been generally assumed to be released into the extracellular environment by the cells of origin, whereupon it effects its well-known mediator functions.
(11) Whereupon Gore uttered the immortal phrase: "But what about the Dingle-Norwood bill?"
(12) Severe leucopenia was observed in 2 patients, whereupon therapy was definitely withdrawn.
(13) Whereupon Gove went back into his customary role of baiting Hunt for making up Labour's education policy on the hoof.
(14) We report a case of a 20-year-ol women whose pineal region tumour was irradiated, whereupon a unilateral low-frequency resting and intention tremor developed.
(15) In the disk, the region proximal to the RNA binding site is in a random coil until the RNA binds, whereupon the 24 residues involved build a well-defined structure, thereby encapsulating the RNA.
(16) The latter increased again rapidly to rates above normal until antigen expression reached normal level, whereupon the protein synthesis rate decreased to normal.
(17) The temperature of dispersions caused no increase in CF release until the gel-to-liquid crystalline transition temperature was exceeded (54.6 degrees C), whereupon a 20% increase in leakage was observed after 80 min of nebulization.
(18) The key step in the preparation of 15 was the epoxide-ring opening of methyl 2,3-anhydro-4-O-benzyl-6-deoxy-alpha-L-gulopyranoside with KHF2 in ethylene glycol, whereupon 2-fluoro-alpha-L-idopyranoside was obtained.
(19) It is concluded that inhibition of thrombin adsorbed on the heparin surface occurs as follows: Added AT adheres to high affinity heparin fragments on the surface whereupon adsorbed thrombin migrates in the hydrophilic heparin coating towards the reaction site of AT and becomes inhibited.
(20) They made the second round for the first time in 2002, whereupon a combined South Korea & Matchday Officials outfit breezed past Italy and Spain to make the semis.