(n.) Doing; trouble; difficulty; troublesome business; fuss; bustle; as, to make a great ado about trifles.
Example Sentences:
(1) This inhibition was correlated with the enhanced Ado toxicity, suggesting inhibition of methylation as a possible causal factor for the great increase in Ado sensitivity.
(2) S-Adenosyl-L-methionine (Ado-met) administration to rats significantly improved liver necrosis induced by thioacetamide (TAA) as evidenced by reduction of TAA-elevated catalytic activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALAT).
(3) Apparent Michaelis (Km) constants for the two cosubstrates for the reaction, 6-MP and S-adenosyl-L-methionine (Ado-Met), in mouse kidney were 7.0 X 10(-4) M and 2.4 X 10(-6) M respectively.
(4) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(5) Both 20 microM nitrobenzylthioinosine (NBMPR), an inhibitor of the purine nucleoside carrier, and 0.1 mM alpha,beta-methylene adenosine diphosphate (AOPCP), an inhibitor of 5'-nucleotidase activity, attenuate DNP-stimulated ADO release (NBMPR by 62% and ADOCP by 76%).
(6) The effect of adenosine (ADO) on the recovery of cellular adenine nucleotides (AN) was evaluated in the cultured cells deprived of oxygen and substrates (ischemia) and in nonischemic cells (control).
(7) The brain dialysis technique was used to (a) deliver drugs locally to brain tissue, (b) estimate cerebral ISF ADO levels, and (c) measure local CBF (hydrogen clearance).
(8) The present experiments were designed to examine the effects of Ado and adenosine analogues on net chloride (JCl) and bicarbonate (JHCO3) absorption by the isolated, perfused MTAL of the rat.
(9) In other tissues, such as adipose and skeletal muscle, much attention has focused on the role of ADO as a metabolic regulator of the actions of insulin.
(10) Adenosine (ADO) in low micromolar levels and hypoxanthine (HYP) in millimolar levels have been shown to inhibit maturation of cumulus-enclosed oocytes.
(11) Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions.
(12) These results suggest that the beta-adrenergic stimulation the interstitial level of ADO in the heart increases to levels that are sufficient to manifest its antiadrenergic effects.
(13) In an experiment with tRNAPhe which is a substrate for a single, namely m5C methylase, the type of inhibition of this methylase by S-Cyd-Hcy was revealed; it was found to be non-competitive with respect to S-Ado-Met, and the S-Cyd-Hcy concentration reducing the methylation by 50 percent was 1.2-10(-4) M.
(14) He also appeared in a number of Branagh's films including Much Ado About Nothing (1993) and as Polonius in Hamlet (1996).
(15) These results provide indirect evidence that in enterocytes methylmalonyl-CoA mutase, the coenzyme of which is Ado-Cbl, is located in the mitochondrial fraction and that methionine synthetase, the coenzyme of which is Me-Cbl, is located in the sap fraction.
(16) Now Michael, what was the word I just said?” I told her the word was “Monday” and, with no more ado, she returned to her desk and clattered something out on her computer.
(17) Nevertheless, the antiviral action of F-C-Ado appears to be targeted at AdoHcy hydrolase.
(18) Low (nM) amounts of the Ado agonists inhibited cAMP formation in both cell types.
(19) This was confirmed by the comparison of the rates of hydrolysis of m7Guo5'PPP5'Ado by the enzyme in the presence of various nucleotides.
(20) He owed his late-flourishing film career to Branagh, appearing in a string of his movies: as Bardolph in Henry V (1989), Leonato in Much Ado About Nothing (1993), the old blind man in Mary Shelley's Frankenstein (1994), a cantankerous old thespian in A Midwinter's Tale (1995), Polonius in Hamlet (1996) and Sir Nathaniel in the musical Love's Labour's Lost (2000).
Tie
Definition:
(v. t.) A knot; a fastening.
(v. t.) A bond; an obligation, moral or legal; as, the sacred ties of friendship or of duty; the ties of allegiance.
(v. t.) A knot of hair, as at the back of a wig.
(v. t.) An equality in numbers, as of votes, scores, etc., which prevents either party from being victorious; equality in any contest, as a race.
(v. t.) A beam or rod for holding two parts together; in railways, one of the transverse timbers which support the track and keep it in place.
(v. t.) A line, usually straight, drawn across the stems of notes, or a curved line written over or under the notes, signifying that they are to be slurred, or closely united in the performance, or that two notes of the same pitch are to be sounded as one; a bind; a ligature.
(v. t.) Low shoes fastened with lacings.
(v. t.) To fasten with a band or cord and knot; to bind.
(v. t.) To form, as a knot, by interlacing or complicating a cord; also, to interlace, or form a knot in; as, to tie a cord to a tree; to knit; to knot.
(v. t.) To unite firmly; to fasten; to hold.
(v. t.) To hold or constrain by authority or moral influence, as by knotted cords; to oblige; to constrain; to restrain; to confine.
(v. t.) To unite, as notes, by a cross line, or by a curved line, or slur, drawn over or under them.
(v. t.) To make an equal score with, in a contest; to be even with.
(v. i.) To make a tie; to make an equal score.
Example Sentences:
(1) Behind her balcony, decorated with a flourishing pothos plant and a monarch butterfly chrysalis tied to a succulent with dental floss, sits the university’s power plant.
(2) Theresa May signals support for UK-EU membership deal Read more Faull’s fix, largely accepted by Britain, also ties the hands of national governments.
(3) The quantity of social ties, the quality of relationships as modified by type of intimate, and the baseline level of symptoms measured five years earlier were significant predictors of psychosomatic symptoms among this sample of women.
(4) They are just literally lying.” In August Microsoft severed its ties, saying Alec’s stance on climate change and several other issues “conflicted directly with Microsoft’s values”.
(5) There is a gradual loosening of the adolescent's emotional dependence on her parents and a transfer of dependency ties to peers.
(6) We have reported on a simple and secure method of tying up hair during transplantation surgery for alopecia.
(7) Maybe it’s because they are skulking, sedentary creatures, tied to their post; the theatre critic isn’t going anywhere other than the stalls, and then back home to write.
(8) Beijing has no interest in seeing strained ties affecting development plans either.” The Moranbong band was founded by Kim Jong-un , with each member reportedly selected by a leader eager to make his mark on the cultural scene.
(9) Two years ago I met a wonderful man and we now feel it’s time to tie the knot.
(10) The glory lay in the defiance, although the outcome of the tie scarcely looks promising for Arsenal when the return at Camp Nou next Tuesday is borne in mind.
(11) Alec played a role in the resignation of the UK defence secretary Liam Fox last year over his close ties to his friend Adam Werritty.
(12) The Dodgers and Braves are tied 1-1 in the third inning and the Detroit Tigers and Oakland A's ALDS will start at 9:37pm EST.
(13) And if that ties up with one another then Oscar has got a major problem."
(14) Los Angeles were relentless in their vicious pursuit of a game-tying goal on Wednesday, bidding to send Game 4 into overtime.
(15) "This is the guy we've all seen in Borders or HMV on a Friday afternoon, possibly after a drink or two, tie slightly undone, buying two CDs, a DVD and maybe a book - fifty quid's worth - and frantically computing how he's going to convince his partner that this is a really, really worthwhile investment."
(16) The levy would also confirm the dramatically changing nature of Pakistan's ties with its western partners, from a strategic alliance to a transactional relationship, with deep suspicions on both sides.
(17) Trade unions criticised the corporation’s 1% offer, tied to a minimum of just £390, for those staff earning under £50,000, calling it “completely unacceptable” .
(18) Unlike most CDU politicians, he keeps close ties to the British Conservatives despite their differences on Europe .
(19) Last week, the army major who ordered Dar to be tied to the vehicle was awarded a commendation for his counter-insurgency work in the region.
(20) He added, however, that the US would "remain the world's leading military and economic power for the next two to three decades" and he ruled out a radical shift in bilateral ties.