(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Dreadful
Definition:
(a.) Full of dread or terror; fearful.
(a.) Inspiring dread; impressing great fear; fearful; terrible; as, a dreadful storm.
(a.) Inspiring awe or reverence; awful.
Example Sentences:
(1) Thinking I had the dreaded Norovirus, I rushed home.
(2) We should be grateful the School Food Trust has established this now, before we end up falling down a slippery slope back towards the dreaded Turkey Twizzler that Jamie Oliver campaigned to banish," he added.
(3) So what should those who have long dreaded this moment do now?
(4) Dr Bhambra sustained the most dreadful life-changing injuries during a sustained racist attack on an innocent man, a member of a caring profession.” There was applause from the public gallery as the verdict was returned.
(5) Despite a dreadful end to last season, culminating in a 6-1 defeat at Stoke City, FSG are pressing ahead with transfer plans agreed with Rodgers, indicating the manager’s position is safe at the moment.
(6) The image of older people, epitomised in the dreadful road sign, is about health and disability, but poverty is an equally defining feature, so we could talk about older people dependent on social security and those who have other sources of income.
(7) Panic attacks would overwhelm her periodically and she experienced regular “ scanxiety ” – the feelings of dread that grip patients before new tests.
(8) If you are a London commuter dreading tube strike chaos this evening and tomorrow there is an alternative to fighting your way on to overcrowded buses or a long walk.
(9) Many clinicians have realised that AIDS is only the most dreadful aspect of HIV infection.
(10) I have to say I think Iran are the poorest team I've seen so far – Nigeria were dreadful in that game but you got the sense that at leas they were a half-decent team playing badly.
(11) After expressing frustration with Stoke City's style of play, the dreadful standard of the game and the lack of width available on a pitch narrowed to exploit Rory Delap's throw-ins, Tony Mowbray finally realised that a sixth defeat in seven matches might also owe something to West Bromwich Albion's shortcomings.
(12) Thus China replaced a state bureaucracy with a similar state bureaucracy under a different name, the USSR replaced the dreaded imperial secret police with an even more dreaded secret police, and so forth.
(13) It's unfair to single him out on the basis of a performance in which almost all of his team-mates have been dreadful, but he's been consistently awful throughout this tournament and keeps getting picked.
(14) They'll dread the same thing happening again, possibly during an election campaign.
(15) Despite his humorous dismissal of the danger, those close to him dreaded the trips, with the archbishop of York, Dr John Sentamu, admitting: "My heart is in my mouth every time he goes to Nigeria."
(16) So Richard arose as himself again, a dreadful apparition cavorting.
(17) Try Penny Dreadful Read more Conleth Hill, who plays Machiavellian royal fixer Varys, kept the crowd in stitches.
(18) Even after yesterday's dreadful GDP figures , a year on from the financial firestorm, it has become apparent that we are not about to suffer a full rerun of America's Great Depression.
(19) CSKA Moscow survive PSV Eindhoven fightback after Seydou Doumbia double Read more Van Gaal, clearly unenthused by the team’s display, cannot have missed another limited performance from Wayne Rooney, most notable for a fairly dreadful shot when Anthony Martial’s quick feet and directness gave him a chance after 20 minutes.
(20) Soubry compared nicotine to heroin as she spoke of how she found it difficult to give up smoking because nicotine is a "dreadful substance" that creates a "perverse psychology of smoking".