(v. t.) To tie, or confine with a cord, band, ligature, chain, etc.; to fetter; to make fast; as, to bind grain in bundles; to bind a prisoner.
(v. t.) To confine, restrain, or hold by physical force or influence of any kind; as, attraction binds the planets to the sun; frost binds the earth, or the streams.
(v. t.) To cover, as with a bandage; to bandage or dress; -- sometimes with up; as, to bind up a wound.
(v. t.) To make fast ( a thing) about or upon something, as by tying; to encircle with something; as, to bind a belt about one; to bind a compress upon a part.
(v. t.) To prevent or restrain from customary or natural action; as, certain drugs bind the bowels.
(v. t.) To protect or strengthen by a band or binding, as the edge of a carpet or garment.
(v. t.) To sew or fasten together, and inclose in a cover; as, to bind a book.
(v. t.) Fig.: To oblige, restrain, or hold, by authority, law, duty, promise, vow, affection, or other moral tie; as, to bind the conscience; to bind by kindness; bound by affection; commerce binds nations to each other.
(v. t.) To bring (any one) under definite legal obligations; esp. under the obligation of a bond or covenant.
(v. t.) To place under legal obligation to serve; to indenture; as, to bind an apprentice; -- sometimes with out; as, bound out to service.
(v. i.) To tie; to confine by any ligature.
(v. i.) To contract; to grow hard or stiff; to cohere or stick together in a mass; as, clay binds by heat.
(v. i.) To be restrained from motion, or from customary or natural action, as by friction.
(v. i.) To exert a binding or restraining influence.
(n.) That which binds or ties.
(n.) Any twining or climbing plant or stem, esp. a hop vine; a bine.
(n.) Indurated clay, when much mixed with the oxide of iron.
(n.) A ligature or tie for grouping notes.
Example Sentences:
(1) Tryptic digestion of the membranes caused complete disappearance of the binding activity, but heat-treatment for 5 min at 70 degrees C caused only 40% loss of activity.
(2) Comparison of the S100 alpha-binding protein profiles in fast- and slow-twitch fibers of various species revealed few, if any, species- or fiber type-specific S100 binding proteins.
(3) Competition with the labelled 10B12 MAb for binding to the purified antigen was demonstrated in sera of tumor-bearing and immune rats.
(4) These studies led to the following conclusions: (a) all the prominent NHP which remain bound to DNA are also present in somewhat similar proportions in the saline-EDTA, Tris, and 0.35 M NaCl washes of nuclei; (b) a protein comigrating with actin is prominent in the first saline-EDTA wash of nuclei, but present as only a minor band in the subsequent washes and on washed chromatin; (c) the presence of nuclear matrix proteins in all the nuclear washes and cytosol indicates that these proteins are distributed throughout the cell; (d) a histone-binding protein (J2) analogous to the HMG1 protein of K. V. Shooter, G.H.
(5) Power urges the security council to "take the kind of credible, binding action warranted."
(6) The binding properties of formalin-fixed amelanotic melanoma cells were not identical to those of endothelial or unfixed target cells.
(7) Such an increase in antibody binding occurred simultaneously with an increase in the fluidity of surface lipid regions, as monitored by fluorescence depolarization of 1-(trimethylammoniophenyl)-6-phenyl-1,3,5-hexatriene.
(8) It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by nuclear translocation.
(9) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(10) Theoretical computations are performed of the intercalative binding of the neocarzinostatin chromophore (NCS) with the double-stranded oligonucleotides d(CGCG)2, d(GCGC)2, d(TATA)2 and d(ATAT)2.
(11) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(12) It was also able to inhibit the binding both of alpha-bungarotoxin and rabies virus glycoprotein to the acetylcholine receptor.
(13) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(14) The procedure used in our laboratory was not able to provide accurate determination of the concentrations of these binding forms.
(15) The occupation of the high affinity calcium binding site by Ca(II) and Mn(II) does not influence the Cu(II) binding process, suggesting that there is no direct interaction between this site and the Cu(II) binding sites.
(16) PMN were found to be nonpermissive for HSV replication and were unable to bind virus in the absence of antibody.
(17) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(18) The transported pIgA was functional, as evidenced by its ability to bind to virus in an ELISA assay and to protect nonimmune mice against intranasal infection with H1N1 but not H3N2 influenza virus.
(19) The monoclonal antibody (mAb), SY38, binds to a cytoplasmic domain of synaptophysin.
(20) Binding data for both ligands to the enzyme yielded nonlinear Scatchard plots that analyze in terms of four negatively cooperative binding sites per enzyme tetramer.
Free
Definition:
(superl.) Exempt from subjection to the will of others; not under restraint, control, or compulsion; able to follow one's own impulses, desires, or inclinations; determining one's own course of action; not dependent; at liberty.
(superl.) Not under an arbitrary or despotic government; subject only to fixed laws regularly and fairly administered, and defended by them from encroachments upon natural or acquired rights; enjoying political liberty.
(superl.) Liberated, by arriving at a certain age, from the control of parents, guardian, or master.
(superl.) Not confined or imprisoned; released from arrest; liberated; at liberty to go.
(superl.) Not subjected to the laws of physical necessity; capable of voluntary activity; endowed with moral liberty; -- said of the will.
(superl.) Clear of offense or crime; guiltless; innocent.
(superl.) Unconstrained by timidity or distrust; unreserved; ingenuous; frank; familiar; communicative.
(superl.) Unrestrained; immoderate; lavish; licentious; -- used in a bad sense.
(superl.) Not close or parsimonious; liberal; open-handed; lavish; as, free with his money.
(superl.) Exempt; clear; released; liberated; not encumbered or troubled with; as, free from pain; free from a burden; -- followed by from, or, rarely, by of.
(superl.) Characteristic of one acting without restraint; charming; easy.
(superl.) Ready; eager; acting without spurring or whipping; spirited; as, a free horse.
(superl.) Invested with a particular freedom or franchise; enjoying certain immunities or privileges; admitted to special rights; -- followed by of.
(superl.) Thrown open, or made accessible, to all; to be enjoyed without limitations; unrestricted; not obstructed, engrossed, or appropriated; open; -- said of a thing to be possessed or enjoyed; as, a free school.
(superl.) Not gained by importunity or purchase; gratuitous; spontaneous; as, free admission; a free gift.
(superl.) Not arbitrary or despotic; assuring liberty; defending individual rights against encroachment by any person or class; instituted by a free people; -- said of a government, institutions, etc.
(superl.) Certain or honorable; the opposite of base; as, free service; free socage.
(superl.) Privileged or individual; the opposite of common; as, a free fishery; a free warren.
(superl.) Not united or combined with anything else; separated; dissevered; unattached; at liberty to escape; as, free carbonic acid gas; free cells.
(adv.) Freely; willingly.
(adv.) Without charge; as, children admitted free.
(a.) To make free; to set at liberty; to rid of that which confines, limits, embarrasses, oppresses, etc.; to release; to disengage; to clear; -- followed by from, and sometimes by off; as, to free a captive or a slave; to be freed of these inconveniences.
(a.) To remove, as something that confines or bars; to relieve from the constraint of.
(a.) To frank.
Example Sentences:
(1) Cancer patients showed abnormally high plasma free tryptophan levels.
(2) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(3) The authors have presented in two previous articles the graphic solutions resembling Tscherning ellipses, for spherical as well as for aspherical ophthalmic lenses free of astigmatism or power error.
(4) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(5) With NaCl as the major constituent of the bathing solution (potassium-free pipette and external solutions) the reversal potential (Er) of the noradrenaline-evoked current was about 0 mV.
(6) In cardiac tissue the adenylate system is not a good indicator of the energy state of the mitochondrion, even when the concentrations of AMP and free cytosolic ADP are calculated from the adenylate kinase and creatine kinase equilibria.
(7) The promoters of the adenovirus 2 major late gene, the mouse beta-globin gene, the mouse immunoglobulin VH gene and the LTR of the human T-lymphotropic retrovirus type I were tested for their transcription activities in cell-free extracts of four cell lines; HeLa, CESS (Epstein-Barr virus-transformed human B cell line), MT-1 (HTLV-I-infected human T cell line without viral protein synthesis), and MT-2 (HTLV-I-infected human T cell line producing viral proteins).
(8) This frees the student to experience the excitement and challenge of learning and the joy of helping people.
(9) The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of O2 radicals and an inhibitor of xanthine oxidase.
(10) This sling was constructed bu freeing the insertion of the pubococcygeus and the ileococcygeus muscles from the coccyx.
(11) In Ca free-solution phenylephrine inhibited the response to CaCl2.
(12) The actuarial 5-year disease-free survival rates were 83% (group 1), 83% (group 2), and 100% (group 3).
(13) Their effects on various lipid fractions, viz., triglycerides (TG), phospholipids, free cholesterol, and esterified cholesterol, were studied in liver, plasma, gonads, and muscle.
(14) These deficiencies in the data compromise HIV surveillance based on diagnostic testing, and supplementary bias-free data are needed.
(15) The authors conclude that H. pylori alone causes little or no effect on an intact gastric mucosa in the rat, that either intact organisms or bacteria-free filtrates cause similar prolongation and delayed healing of pre-existing ulcers with active chronic inflammation, and that the presence of predisposing factors leading to disruption of gastric mucosal integrity may be required for the H. pylori enhancement of inflammation and tissue damage in the stomach.
(16) Only those derivatives with a free amino group and net positive charge in the side chain were effective.
(17) Under milder trypsin digestion conditions three resistant fragments were produced from the free protein.
(18) "This was very strategic and it was in line of the ideology of the Bush administration which has been to put in place a free market and conservative agenda."
(19) To determine the influence of cetylpyridinium chloride (CPC) adsorption on the wettability and elemental surface composition of human enamel, with and without adsorbed salivary constituents, surface-free energies and elemental compositions were determined.
(20) By growing purified human cytotrophoblasts under serum-free conditions and manipulating the culture surface, we were able to disassociate morphologic from biochemical differentiation.