(n.) An invitation to engage in a contest or controversy of any kind; a defiance; specifically, a summons to fight a duel; also, the letter or message conveying the summons.
(n.) The act of a sentry in halting any one who appears at his post, and demanding the countersign.
(n.) A claim or demand.
(n.) The opening and crying of hounds at first finding the scent of their game.
(n.) An exception to a juror or to a member of a court martial, coupled with a demand that he should be held incompetent to act; the claim of a party that a certain person or persons shall not sit in trial upon him or his cause.
(n.) An exception to a person as not legally qualified to vote. The challenge must be made when the ballot is offered.
(n.) To call to a contest of any kind; to call to answer; to defy.
(n.) To call, invite, or summon to answer for an offense by personal combat.
(n.) To claim as due; to demand as a right.
(n.) To censure; to blame.
(n.) To question or demand the countersign from (one who attempts to pass the lines); as, the sentinel challenged us, with "Who comes there?"
(n.) To take exception to; question; as, to challenge the accuracy of a statement or of a quotation.
(n.) To object to or take exception to, as to a juror, or member of a court.
(n.) To object to the reception of the vote of, as on the ground that the person in not qualified as a voter.
(v. i.) To assert a right; to claim a place.
Example Sentences:
(1) Bronchial challenge caused an immediate asthmatic response.
(2) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(3) This frees the student to experience the excitement and challenge of learning and the joy of helping people.
(4) The degree of increase in Meth responsiveness elicited by the initial provocation is a major factor in determining the airway response to a subsequent HS challenge.
(5) Intranasal challenge of allergic subjects with the allergen to which they are sensitive rapidly produces sneezing, rhinorrhea, and airway obstruction.
(6) Matthias Müller, VW’s chief executive, said: “In light of the wide range of challenges we are currently facing, we are satisfied overall with the start we have made to what will undoubtedly be a demanding fiscal year 2016.
(7) In 1935, Einstein challenged the prevailing interpretation of quantum theory.
(8) A shrinking populace is perhaps a greater challenge than any problems with Russia.
(9) Intraperitoneal injection of indomethacin to pretreated animals resulted in increased levels of IL-1 and TNF and decreased levels of PGE2 following challenge with E. coli.
(10) Think of Nelson Mandela – there is a determination, an unwillingness to bend in the face of challenges, that earns you respect and makes people look to you for guidance.
(11) The children's pulse, pulse rate variability, and blood pressure were then measured at rest and during a challenging situation.
(12) At first it looked as though the winger might have shown too much of the ball to the defence, yet he managed to gain a crucial last touch to nudge it past Phil Jones and into the path of Jerome, who slipped Chris Smalling’s attempt at a covering tackle and held off Michael Carrick’s challenge to place a shot past an exposed De Gea.
(13) The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally.
(14) The role of blood acetylcholinesterase in moderating the effects of organophosphate challenge in rats was tested.
(15) In the first trial to investigate the effect of tick control, significant improvements in liveweight gain (LWG) occurred only in periods of medium to high challenge with adult Amblyomma variegatum.
(16) The SNT and the I-ELISA indicated that the pigs responded to vaccination and challenge.
(17) When caffeine evokes a contraction, and only then, crayfish muscle fibers become refractory to a second challenge with caffeine for up to 20 min in the standard saline (5 mM K(o)).
(18) This observation seriously challenges the hypothesis that SCE cancellation results as a consequence of persistence of the lesions induced by these agents.
(19) Injection of about four ImD 50 of vaccine intracerebrally produced a local immunity, resulting in an immediate kill of challenge organisms given 14 days later.
(20) There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier.
Hard
Definition:
(superl.) Not easily penetrated, cut, or separated into parts; not yielding to pressure; firm; solid; compact; -- applied to material bodies, and opposed to soft; as, hard wood; hard flesh; a hard apple.
(superl.) Difficult, mentally or judicially; not easily apprehended, decided, or resolved; as a hard problem.
(superl.) Difficult to accomplish; full of obstacles; laborious; fatiguing; arduous; as, a hard task; a disease hard to cure.
(superl.) Difficult to resist or control; powerful.
(superl.) Difficult to bear or endure; not easy to put up with or consent to; hence, severe; rigorous; oppressive; distressing; unjust; grasping; as, a hard lot; hard times; hard fare; a hard winter; hard conditions or terms.
(superl.) Difficult to please or influence; stern; unyielding; obdurate; unsympathetic; unfeeling; cruel; as, a hard master; a hard heart; hard words; a hard character.
(superl.) Not easy or agreeable to the taste; stiff; rigid; ungraceful; repelling; as, a hard style.
(superl.) Rough; acid; sour, as liquors; as, hard cider.
(superl.) Abrupt or explosive in utterance; not aspirated, sibilated, or pronounced with a gradual change of the organs from one position to another; -- said of certain consonants, as c in came, and g in go, as distinguished from the same letters in center, general, etc.
(superl.) Wanting softness or smoothness of utterance; harsh; as, a hard tone.
(superl.) Rigid in the drawing or distribution of the figures; formal; lacking grace of composition.
(superl.) Having disagreeable and abrupt contrasts in the coloring or light and shade.
(adv.) With pressure; with urgency; hence, diligently; earnestly.
(adv.) With difficulty; as, the vehicle moves hard.
(adv.) Uneasily; vexatiously; slowly.
(adv.) So as to raise difficulties.
(adv.) With tension or strain of the powers; violently; with force; tempestuously; vehemently; vigorously; energetically; as, to press, to blow, to rain hard; hence, rapidly; as, to run hard.
(adv.) Close or near.
(v. t.) To harden; to make hard.
(n.) A ford or passage across a river or swamp.
Example Sentences:
(1) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(2) Sierra Leone is one of the three West Africa nations hit hard by an Ebola epidemic this year.
(3) Topical and systemic antibiotic therapy is common in dermatology, yet it is hard to find a rationale for a particular route in some diseases.
(4) Given Australia’s number one position as the worst carbon emitter per capita among major western nations it seems hardly surprising that islanders from Fiji, Samoa, Vanuatu and other small island developing states have been turning to Australia with growing exasperation demanding the country demonstrate an appropriate response and responsibility.
(5) They had learned through hard experience what Frederick Douglass once taught -- that freedom is not given, it must be won, through struggle and discipline, persistence and faith.
(6) In 60 rhesus monkeys with experimental renovascular malignant arterial hypertension (25 one-kidney and 35 two-kidney model animals), we studied the so-called 'hard exudates' or white retinal deposits in detail (by ophthalmoscopy, and stereoscopic color fundus photography and fluorescein fundus angiography, on long-term follow-up).
(7) It is a moment to be grateful for what remains of Labour's hard left: an amendment to scrap the cap was at least tabled by John McDonnell and Jeremy Corbyn but stood no chance.
(8) She stopped working only when the pain made it hard for her to get to work.
(9) He was reclusive, I know that, and he was often given a hard time for it.
(10) This defeat, though, is hardly a good calling card for the main job.
(11) Since this test is easily performed and hardly stresses the patient, it should routinely be the initial one for the diagnosis of renal osteopathy.
(12) Never become so enamored of your own smarts that you stop signing up for life’s hard classes.
(13) But I don't wish to be too hard on the judge for not taking that view.
(14) Our campaign has been going for some time and each step in our progress has been hard won, by campaigners paid and volunteer alike.
(15) I am rooting hard for you.” Ronald Reagan simply told his former vice-president Bush: “Don’t let the turkeys get you down.” By 10.30am Michelle Obama and Melania Trump will join the outgoing and incoming presidents in a presidential limousine to drive to the Capitol.
(16) All the same, it's hard to approach the school, which charges nearly £28,000 for boarders and nearly £19,000 for day girls and is sometimes called "the girls' Eton", without a few prejudices.
(17) Governmental officials as well as medical scientists in Taiwan have worked hard in recent years to develop and to implement various measures, such as prenatal diagnosis and neonatal screening, to lower the incidence of hereditary diseases and mental retardation in the population.
(18) Cooper, who was briefly a social worker in Los Angeles, also suggests working hard to build a rapport with colleagues in hotdesking situations.
(19) Critics of wind power peddle the same old myths about investment in new energy sources adding to families' fuel bills , preferring to pick a fight with people concerned about the environment, than stand up to vested interests in the energy industry, for the hard-pressed families and pensioners being ripped off by the energy giants.
(20) The spirit is great here, the players work very hard, we kept the belief when we were in third place and now we are here.