(n.) An invitation to engage in a contest or controversy of any kind; a defiance; specifically, a summons to fight a duel; also, the letter or message conveying the summons.
(n.) The act of a sentry in halting any one who appears at his post, and demanding the countersign.
(n.) A claim or demand.
(n.) The opening and crying of hounds at first finding the scent of their game.
(n.) An exception to a juror or to a member of a court martial, coupled with a demand that he should be held incompetent to act; the claim of a party that a certain person or persons shall not sit in trial upon him or his cause.
(n.) An exception to a person as not legally qualified to vote. The challenge must be made when the ballot is offered.
(n.) To call to a contest of any kind; to call to answer; to defy.
(n.) To call, invite, or summon to answer for an offense by personal combat.
(n.) To claim as due; to demand as a right.
(n.) To censure; to blame.
(n.) To question or demand the countersign from (one who attempts to pass the lines); as, the sentinel challenged us, with "Who comes there?"
(n.) To take exception to; question; as, to challenge the accuracy of a statement or of a quotation.
(n.) To object to or take exception to, as to a juror, or member of a court.
(n.) To object to the reception of the vote of, as on the ground that the person in not qualified as a voter.
(v. i.) To assert a right; to claim a place.
Example Sentences:
(1) Bronchial challenge caused an immediate asthmatic response.
(2) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(3) This frees the student to experience the excitement and challenge of learning and the joy of helping people.
(4) The degree of increase in Meth responsiveness elicited by the initial provocation is a major factor in determining the airway response to a subsequent HS challenge.
(5) Intranasal challenge of allergic subjects with the allergen to which they are sensitive rapidly produces sneezing, rhinorrhea, and airway obstruction.
(6) Matthias Müller, VW’s chief executive, said: “In light of the wide range of challenges we are currently facing, we are satisfied overall with the start we have made to what will undoubtedly be a demanding fiscal year 2016.
(7) In 1935, Einstein challenged the prevailing interpretation of quantum theory.
(8) A shrinking populace is perhaps a greater challenge than any problems with Russia.
(9) Intraperitoneal injection of indomethacin to pretreated animals resulted in increased levels of IL-1 and TNF and decreased levels of PGE2 following challenge with E. coli.
(10) Think of Nelson Mandela – there is a determination, an unwillingness to bend in the face of challenges, that earns you respect and makes people look to you for guidance.
(11) The children's pulse, pulse rate variability, and blood pressure were then measured at rest and during a challenging situation.
(12) At first it looked as though the winger might have shown too much of the ball to the defence, yet he managed to gain a crucial last touch to nudge it past Phil Jones and into the path of Jerome, who slipped Chris Smalling’s attempt at a covering tackle and held off Michael Carrick’s challenge to place a shot past an exposed De Gea.
(13) The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally.
(14) The role of blood acetylcholinesterase in moderating the effects of organophosphate challenge in rats was tested.
(15) In the first trial to investigate the effect of tick control, significant improvements in liveweight gain (LWG) occurred only in periods of medium to high challenge with adult Amblyomma variegatum.
(16) The SNT and the I-ELISA indicated that the pigs responded to vaccination and challenge.
(17) When caffeine evokes a contraction, and only then, crayfish muscle fibers become refractory to a second challenge with caffeine for up to 20 min in the standard saline (5 mM K(o)).
(18) This observation seriously challenges the hypothesis that SCE cancellation results as a consequence of persistence of the lesions induced by these agents.
(19) Injection of about four ImD 50 of vaccine intracerebrally produced a local immunity, resulting in an immediate kill of challenge organisms given 14 days later.
(20) There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier.
Tough
Definition:
(superl.) Having the quality of flexibility without brittleness; yielding to force without breaking; capable of resisting great strain; as, the ligaments of animals are remarkably tough.
(superl.) Not easily broken; able to endure hardship; firm; strong; as, tough sinews.
(superl.) Not easily separated; viscous; clammy; tenacious; as, tough phlegm.
(superl.) Stiff; rigid; not flexible; stubborn; as, a tough bow.
(superl.) Severe; violent; as, a tough storm.
Example Sentences:
(1) Photograph: Guardian The research also compiled data covered by a wider definition of tax haven, including onshore jurisdictions such as the US state of Delaware – accused by the Cayman islands of playing "faster and looser" even than offshore jurisdictions – and the Republic of Ireland, which has come under sustained pressure from other EU states to reform its own low-tax, light-tough, regulatory environment.
(2) Nick Robins, head of the Climate Change Centre at HSBC, said: "If you think about low-carbon energy only in terms of carbon, then things look tough [in terms of not using coal].
(3) A series of hierarchical multiple regressions revealed the effects of Surgency, Agreeableness, Conscientiousness, Emotional Stability, and Intellect on evoking upset in spouses through condescension (e.g., treating spouse as stupid or inferior), possessiveness (demanding too much time and attention), abuse (slapping spouse), unfaithfulness (having sex with others), inconsiderateness (leaving toilet seat up), moodiness (crying a lot), alcohol abuse (drinking too much alcohol), emotional constriction (hiding emotions to act tough), and self-centeredness (acting selfishly).
(4) A lfred Ekpenyong knows first hand how tough it can be to find a secure foothold in mainstream society after leaving prison.
(5) The texture of a food item can be distinguished in hardness, toughness, stickiness, juiciness and chewability.
(6) Even as the Obama administration moves to deal with some of Guantánamo's most notorious captives, it faces tough challenges to closing the facility.
(7) "It's a tough group but other groups are also tough.
(8) This allowed it to claim that it was becoming more professional, tough minded and responsible.
(9) The austerity programmes administered by western governments in the wake of the 2008 global financial crisis were, of course, intended as a remedy, a tough but necessary course of treatment to relieve the symptoms of debts and deficits and to cure recession.
(10) And he pleased the audience with an acknowledgement that social work is a tough job and social workers only human.
(11) Trade unions have sought to highlight the insecurity of workers who have been forced into self-employment in the tough jobs market of recent years.
(12) UK negotiatiors, though, fought back hard -- thus Cameron's fighting talk in his press conference ( see 12.46pm ) 12.49pm BST Open Europe tweets Cameron's tough talk on the rebate: Open Europe (@OpenEurope) Cameron: in Feb we reached a clear deal rebate would remain unchanged, since then some have tried to question this agreement June 28, 2013 Open Europe (@OpenEurope) Cameron: I defeated these attempts to change the rebate, it will remain unchanged for this long term budget June 28, 2013 12.46pm BST David Cameron press conference underway In Brussels, David Cameron is holding his press conference now.
(13) The mechanical properties of compressed beam specimens of microcrystalline cellulose (Avicel pH 101) have been assessed in terms of the tensile strength (sigma t), Young's modulus (E) and the following fracture mechanics parameters: the critical stress intensity factor (KIC), the critical strain energy release rate (GIC) and the fracture toughness (R).
(14) "2013 was a tough year for us both in minerals and in oil and gas," Cochrane said, adding that the group had relied on"self help", including diversification which offset some of the challenges in its core mining market, improving operational efficiency, and strong growth in its after sales business, where orders were up 16% on 2012 and which accounted for 63% of revenues last year.
(15) "We carved out a few chances, but it was tough to break them down."
(16) Channel 5 will be hoping for a similar return for its new series, although with the launch audience around a third down on last year's opener, it may prove a tough ask.
(17) Dimon, the charismatic leader of the bank, had enjoyed a reputation as a tough, strict taskmaster, the kind of CEO every bank should have.
(18) Cameron put all of his betting chips on what seemed to be the party's trump card: the "vote for us, we're tough on migration and tough on migrants" strategy.
(19) As well as limited terms for MPs, Grillo has called for a referendum on the euro and a tough line on immigration.
(20) "It's a tough game but our best football has come in this competition and we'll try and show it next week.