(n.) A large pebble; a rounded stone not too large to be handled; a small boulder; -- used for paving streets and for other purposes.
Example Sentences:
(1) With its steep hills and cobblestones, the neighbourhood of São Cristóvão in Ouro Preto isn’t an easy place to play football.
(2) He made his way to a spot on the cobblestones not far from the marble mausoleum housing the waxy corpse of Vladimir Lenin , and began to undress.
(3) Protesters crawl out from the tents they have pitched on the cobblestones and huddle in the cold around makeshift fires, as volunteers distribute hot tea and soup.
(4) Dehydration of walls seemingly caused the cobblestones to be transformed into two bands which continued to be separated by a channel.
(5) A 61-yr-old man with Burkitt's lymphoma who presented with 6 months of diarrhea was found, at ileoscopy, to have inflammation of the mucosal narrow lumen, deep linear ulcerations, and a "cobblestone" appearance of the terminal ileum.
(6) To the amazement of the CRS the students regrouped and fought back, overturning cars, building barricades and digging up cobblestones to use as ammunition.
(7) A 5-year-old Asian-Indian female presented with bilateral cobblestone-like peripheral lesions, a single area of chorioretinal atrophy, infero-nasal to the disc, in her right eye and a non-recordable single flash ERG.
(8) Despite the fact that these cells retain their normal cobblestone appearance, the collagen profile in each case changes over a period of 12 days in culture following confluence, the changes following distinct patterns.
(9) The cells grow with a cobblestone monolayer morphology, possess angiotensin converting enzyme activity and react with antibodies to Factor VIII antigen.
(10) Changes in the significant radiological signs in Crohn's disease, such as spicula, cobblestone pattern, stenoses and fistulas, provide information on the development of the disease and on the effect of treatment.
(11) Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of extracts prepared from retinol-treated cells which had undergone a remarkable change in shape (from a cobblestone-like to a spindle-like shape) indicated that the retinol-induced morphological change is accompanied by a marked increase of an 80-kDa protein.
(12) Two men aged respectively of 65 and 28 years presented a cobblestone appearance of the gingiva and of the tongue ("pebbly tongue"), which suggested Cowden disease.
(13) Irregular mosaics, intermediate or cobblestone structures were seen in atypical epithelium.
(14) The endothelial cells thus obtained grew to confluence as a cobblestone-like monolayer and expressed von Willebrand factor antigen.
(15) One cell type exhibited cobblestone-like appearance and remained in the center of the islets whereas the other was more loosely arranged and rapidly left the central area by migration below the cobblestone-like cells to the periphery of the islets.
(16) Endothelial cells seeded on this peptide appeared fibroblastic with many extended processes, unlike the normal cobblestone morphology observed on tissue culture plastic.
(17) Histopathologic findings and percentage of eyes affected, in decreasing order of frequency, were myopic configuration of the optic nerve head, 37.7%; posterior staphyloma, 35.4%; degenerative changes of the vitreous, 35.1%; cobblestone degeneration, 14.3%; myopic degeneration of the retina, 11.4%; retinal detachment, 11.4%; retinal pits, holes, or tears, 8.1%; subretinal neovascularization, 5.2%; lattice degeneration, 4.9%; Fuchs spot, 3.2%; and lacquer cracks, 0.6%.
(18) Although rare, these cases provide evidence that IFs in general are not essential to growth in culture, nor are the keratin-containing IFs in particular necessarily responsible for the 'cobblestone' morphology or colony-type growth pattern characteristic of cultured epithelial cells.
(19) Purity of the endothelial cell cultures from each vascular site was assessed by the contact inhibited "cobblestone" monolayer phenotype, by positive immunofluorescence for factor VIII and by angiotensin converting enzyme activity.
(20) The cells lose their usual cobblestone appearance and acquire a fibroblastic, undifferentiated morphology.
Stone
Definition:
(n.) Concreted earthy or mineral matter; also, any particular mass of such matter; as, a house built of stone; the boy threw a stone; pebbles are rounded stones.
(n.) A precious stone; a gem.
(n.) Something made of stone. Specifically: -
(n.) The glass of a mirror; a mirror.
(n.) A monument to the dead; a gravestone.
(n.) A calculous concretion, especially one in the kidneys or bladder; the disease arising from a calculus.
(n.) One of the testes; a testicle.
(n.) The hard endocarp of drupes; as, the stone of a cherry or peach. See Illust. of Endocarp.
(n.) A weight which legally is fourteen pounds, but in practice varies with the article weighed.
(n.) Fig.: Symbol of hardness and insensibility; torpidness; insensibility; as, a heart of stone.
(n.) A stand or table with a smooth, flat top of stone, commonly marble, on which to arrange the pages of a book, newspaper, etc., before printing; -- called also imposing stone.
(n.) To pelt, beat, or kill with stones.
(n.) To make like stone; to harden.
(n.) To free from stones; also, to remove the seeds of; as, to stone a field; to stone cherries; to stone raisins.
(n.) To wall or face with stones; to line or fortify with stones; as, to stone a well; to stone a cellar.
(n.) To rub, scour, or sharpen with a stone.
Example Sentences:
(1) Among its signatories were Michael Moore, Oliver Stone, Noam Chomsky and Danny Glover.
(2) Follow-up studies using radiological methods show worse results (recurrent stones in II: 21.2%, in I: 5.8%, stenosis of EST in II: 6.1%, in I: 3.1%): Late results of EST because of papillary stenosis are still worse compared to those of choledocholithiasis.
(3) Other serious complications were reservoir perforation during catheterisation in 3 and development of stones in the reservoir in 2 patients.
(4) In conclusion, 1) etiology of urinary tract stone in all recurrent stone formers and in all patients with multiple stones must be pursued, and 2) all stones either removed or passed must be subjected to infrared spectrometry.
(5) Predisposition to pancreatitis relates to duct size rather than stone size per se.
(6) Three of these patients, who had a solitary stone could successfully be treated by ESWL as monotherapy.
(7) In cholesterol stones and cholesterolosis specimens, relatively strong muscle strips had similar responses to 10(-6) M cholecystokinin-8 in normal calcium (2.5 mM) and in the absence of extracellular calcium.
(8) No significant complications were related to ESWL and 90% of those followed up after successful ESWL proved stone-free at 6 weeks.
(9) The addition of alcohol to the drinking-water resulted in the formation of stones rich in pigment.
(10) One biliary stone showed cholesterol with spherical bodies of calcium carbonate and pigment.
(11) Israel has complained in recent weeks of an increase in stone throwing and molotov cocktail attacks on West Bank roads and in areas adjoining mainly Palestinian areas of Jerusalem, where an elderly motorist died after crashing his car during an alleged stoning attack.
(12) The first problem facing Calderdale is sheep-rustling Happy Valley – filmed around Hebden Bridge, with its beautiful stone houses straight off the pages of the Guardian’s Lets Move To – may be filled with rolling hills and verdant pastures, but the reality of rural issues are harsh.
(13) The minimal advantage in rapidity of stone dissolution offered by tham E over tham is more than offset by the considerably increased potential for toxic side effects.
(14) The Broken King by Philip Womack Photograph: Troika Books The Sword in the Stone begins with Wart on a "quest" to find a tutor.
(15) It is no longer necessary for the kidney to be free of stones at the end of the operation.
(16) So let's be clear: children taking this drug, which is administered orally, do not get stoned.
(17) Patients with unilateral renal stone(s) with at least 1 diameter between 7 and 25 mm.
(18) Whether they affect ureteral motility in vivo or whether they can counteract ureteral spasm associated with ureteral stones have not been established.
(19) Recurrent stones are usually "silent," and we do not usually treat asymptomatic stones.
(20) Forty impressions were poured with the disinfectant dental stone and a similar number were poured with a comparable, nondisinfectant stone.