(n.) A powerful alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain.
Example Sentences:
(1) Altogether, 29% of the drivers had evidence of alcohol, marijuana, cocaine, prescription or nonprescription stimulants, or some combination of these, in either blood or urine.
(2) Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine.
(3) With chronic cocaine use, neurotransmitter and neuroendocrine alterations occur.
(4) In pentobarbital-anesthetized rats or in perfused hind paw of rats, the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine, but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by I and II.
(5) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(6) When S+ followed cocaine, stereotyped bar-pressing developed with markedly increased responding during the remainder of the session.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(9) Cocaine produces simple hallucinations, PCP can produce complex hallucinations analogous to a paranoid psychosis, while LSD produces a combination of hallucinations, pseudohallucinations and illusions.
(10) Inhibition of DNA synthesis by cocaine in developing brain was not secondary to ischemia, nor to local anesthesia, as alpha-adrenergic blockade with phenoxybenzamine afforded no protection, and lidocaine could not substitute for cocaine.
(11) Cocaine, 3 microM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats.
(12) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(13) However, they do indicate that cocaine is only a weak aversion-inducing agent.
(14) Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied.
(15) The cardiac risk of cocaine body packing was studied by means of continuous ECG monitoring in 13 cocaine body-packers during spontaneous elimination.
(16) We present a 16-year-old with chest pain temporally related to cocaine use and discuss the relationship between cocaine use and acute myocardial infarction that has been seen in the adult population.
(17) Both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions.
(18) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(19) The nine cocaine users, when compared with 14 insulin-dependent diabetics on dialysis matched by protocol, were found to be similar in terms of diabetic retinopathy and metabolic neuropathy.
(20) In view of recent reports demonstrating that illicit cocaine use may cause rhabdomyolysis, we reviewed the collective experience of a university-affiliated medical center to identify patients with cocaine-induced rhabdomyolysis.
Dope
Definition:
Example Sentences:
(1) When allegations of systemic doping and cover-ups first emerged in the runup to the 2013 Russian world athletics championships, an IOC spokesman insisted: “Anti-doping measures in Russia have improved significantly over the last five years with an effective, efficient and new laboratory and equipment in Moscow.” London Olympics were sabotaged by Russia’s doping, report says Read more We now know that the head of that lauded Moscow lab, Grigory Rodchenko, admitted to intentionally destroying 1,417 samples in December last year shortly before Wada officials visited.
(2) It would still need to work with government funded national anti-doping organisations where they exist (though even those considered an example to others, such as UK Anti Doping, are facing swingeing cuts) and bully as well as cajole sports into testing properly with rigour and independence.
(3) Before 2015, Wada did not have the authority to conduct its own investigations under the World Anti-Doping Code, according to Nichols.
(4) Mo Farah must clear air quickly with Alberto Salazar over doping claims Read more Farah intends to speak to his coach, Alberto Salazar, in the next day or so about the serious doping allegations made by Panorama .
(5) The German journalist whose documentary lifted the lid on claims of systematic doping in Russian athletics has said he is prepared to make a follow-up after receiving more evidence.
(6) In Kenya’s case, Wada’s intervention is about forcing the nation’s government to provide the £3.5m needed to fund and staff the fledgling Anti-Doping Agency of Kenya.
(7) However, both 3 h and 14 days after the reinfusion of autologous blood, the mean time of the blood-doped subjects was significantly lower (94.1%; P less than 0.05; 96.3%, P less than 0.05, respectively) than the control group.
(8) "The BOA and the panel both stress that no advance notice out of competition testing is a fundamental part of ensuring an effective fight against doping in sport," he said.
(9) We’re prepared to inform international society about the steps we’re taking, the investigation, the decisions.” Pound’s report, commissioned in the wake of a devastating documentary by the German journalist Hajo Seppelt for ARD in December last year, outlined systemic cheating on a grand scale including a second “shadow lab” that was used to screen samples, anti-doping labs infiltrated by secret service agents and positive tests covered up for cash.
(10) Given a certain somebody gave millions of cancer sufferers false hope by insisting his seven Tour de France wins were the result of a medical miracle rather than the most sophisticated doping programme ever seen in sport, it is hard to keep the faith.
(11) The present technique is suitable for checking and characterizing silicon rods before their neutron-doping.
(12) It was recently shown that oligolamellar vesicles of 3:1 mixtures of dioleoylphosphatidylethanolamine (DOPE) and the photopolymerizable lipid 1,2-bis[10-(2',4'-hexadienoyloxy)decanoyl]-sn-glycero-3-phosphocho line (SorbPC) are destabilized by polymerization of the SorbPC [Lamparski, H., Liman, U., Frankel, D.A., Barry, J.A., Ramaswami, V., Brown, M.F., & O'Brien, D.F.
(13) Russia is only the fifth country to be banned from competition in the IAAF’s 103-year history and the first to be barred for systemic doping.
(14) That process could see Kenya’s national anti-doping agency being declared non-compliant – although insiders were keen to stress the chances of the country being removed from the Olympics were slim because the International Olympic Committee would need to kick Kenya out.
(15) Wada had asked a series of questions to the Kenyan authorities and stressed that we needed the Kenyan government to expedite, and show commitment to, the national anti-doping organisation’s development.
(16) Caution should be practiced with oral contraceptives in dope control of anabolic steroids.
(17) One of Armstrong's former teammates, Floyd Landis, had admitted to doping and accused Armstrong of the same.
(18) Russian officials have acknowledged the country has a problem with doping but denied any government involvement.
(19) The UCI should also pay more attention to medical issues in cycling and when Therapeutic Use Exemptions should be granted Words of warning Sanctioned riders should be used ‘as an educational tool’ to inform their peers about the dangers of doping through interviews, appearances, lectures and recorded messages pointing out the impact of doping on their lives, ‘the social stigma, financial impact, health effects and self-esteem issues’ Voice of the union The UCI should ‘facilitate the creation of a strong riders’ union … to give riders a collective voice particularly on issues of ownership, revenue sharing, the racing calendar and anti-doping.
(20) Last week Kenya missed a deadline to prove to the World Anti-Doping Agency it was doing enough to combat doping, and the IAAF president, Sebastian Coe, refused to rule out the possibility of a ban.