(n.) A powerful alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain.
Example Sentences:
(1) Altogether, 29% of the drivers had evidence of alcohol, marijuana, cocaine, prescription or nonprescription stimulants, or some combination of these, in either blood or urine.
(2) Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine.
(3) With chronic cocaine use, neurotransmitter and neuroendocrine alterations occur.
(4) In pentobarbital-anesthetized rats or in perfused hind paw of rats, the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine, but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by I and II.
(5) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(6) When S+ followed cocaine, stereotyped bar-pressing developed with markedly increased responding during the remainder of the session.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(9) Cocaine produces simple hallucinations, PCP can produce complex hallucinations analogous to a paranoid psychosis, while LSD produces a combination of hallucinations, pseudohallucinations and illusions.
(10) Inhibition of DNA synthesis by cocaine in developing brain was not secondary to ischemia, nor to local anesthesia, as alpha-adrenergic blockade with phenoxybenzamine afforded no protection, and lidocaine could not substitute for cocaine.
(11) Cocaine, 3 microM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats.
(12) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(13) However, they do indicate that cocaine is only a weak aversion-inducing agent.
(14) Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied.
(15) The cardiac risk of cocaine body packing was studied by means of continuous ECG monitoring in 13 cocaine body-packers during spontaneous elimination.
(16) We present a 16-year-old with chest pain temporally related to cocaine use and discuss the relationship between cocaine use and acute myocardial infarction that has been seen in the adult population.
(17) Both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions.
(18) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(19) The nine cocaine users, when compared with 14 insulin-dependent diabetics on dialysis matched by protocol, were found to be similar in terms of diabetic retinopathy and metabolic neuropathy.
(20) In view of recent reports demonstrating that illicit cocaine use may cause rhabdomyolysis, we reviewed the collective experience of a university-affiliated medical center to identify patients with cocaine-induced rhabdomyolysis.
Snort
Definition:
(v. i.) To force the air with violence through the nose, so as to make a noise, as do high-spirited horsed in prancing and play.
(v. i.) To snore.
(v. i.) To laugh out loudly.
(n.) The act of snorting; the sound produced in snorting.
(v. t.) To expel throught the nostrils with a snort; to utter with a snort.
Example Sentences:
(1) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(2) Symptoms of obstructive sleep apnea, a potentially life-threatening disorder, include excessive daytime sleepiness and sleep attacks, nocturnal breath cessation, and snorting and gasping sounds.
(3) In this case a 29-year-old White man presented to the emergency room 3 days after he 'snorted' approximately 200mg of colchicine powder.
(4) The Ohio native suffered from PTSD and a traumatic brain injury, his lawyers say, and he had been drinking contraband alcohol and snorting Valium – both provided by other soldiers – the night of the killings.
(5) Further evidence of apnea can be obtained by determining the presence of the additional signs of loud nocturnal snorting and gasping sounds and nocturnal breath cessations.
(6) The execution of Joseph Wood in Arizona, which left the convicted killer “gasping and snorting” for two hours as the state put him to death, is the third botched delivery of capital punishment this year.
(7) It has moments of snort-out-loud laughter (the paddle steamer named the Wonderful Fanny, the Jane Austen vignette – see below).
(8) Spall's performance has been much celebrated for its emotional depth, despite Turner's vocabulary in the film often consisting of grunts, snorts and spitting saliva onto the canvas.
(9) She won’t say if she’d quit the party if he won, “because it’s not going to happen”, but when later I ask if she would defect from the Tory party today, had she not done so in 2013, she snorts: “Not if Raheem were leading the party.
(10) Most of the time the cast hadn't seen the script until this moment, so the frequent snorts of laughter were music to our ears.
(11) "Nothing to celebrate on the Champs Elysees," snorts Paul Griffin.
(12) Since that time he has been gasping, snorting, and unable to breathe and not dying.
(13) When asked about his inclusion, in 1995, on New York Magazine’s 100 Smartest New Yorkers list, he snorted.
(14) In Crank, famously, he is injected with a poison that will kill him if his adrenaline level drops, leading him to snort cocaine, get in a lot of fights and have sex with his girlfriend in front of a crowd of cheering tourists.
(15) In this study, we are interested in the character of the mucosa and their changes as affected by long-term injury from the trauma of the inspiratory and expiratory air currents, which, on sniffling or snorting, may reach hurricane speeds.
(16) The STS gene has been localised by deletion mapping to the distal tip of the snort arm of the X chromosome, and is of interest in that it appears to escape X-inactivation.
(17) Does the public have an “interest” in what all politicians once said, drank, smoked or snorted, or what they got up to with their lovers or stockbrokers?
(18) They nudge the soft earth or a companion before snorting and continuing on up through the paddocks to the shed.
(19) Recreational cocaine abuse via intranasal "snorting," "free-base" smoking, "body-packing," or intravenous injection can be lethal.
(20) Jon Stewart, who has taken to the story of the crack-smoking mayor like Ford to the pipe, laughed at the city council's apparent toothlessness when attempting to strip him of his mayoral position: "That's justice, Canadian style," he snorted.