(v. t.) To cut into jags or points; to slash; as, to dag a garment.
(v. i.) To be misty; to drizzle.
Example Sentences:
(1) In general, optimal DAGAT activity in vitro was observed when long-chain unsaturated acyl-CoAs and diacylglycerols (DAGs) containing long acyl chains were used as substrates for in vitro TAG synthesis (although 1,2-didecanoin was also very effective).
(2) Incubation of microsomes with CDP-DAG of different fatty acid composition results in quantitative and qualitative differences in lysoPI formation.
(3) We now report that two synthetic diacylglycerols (DAG) replicate the stimulatory and inhibitory effects of TPA on frog skin.
(4) The distribution of PKC returned to control values by 24 h. High glucose did not stimulate phosphoinositide hydrolysis, as evidenced by the absence of an increase in the water-soluble inositol phosphates, indicating that DAG was not generated through the action of a phosphoinositide-specific phospholipase C. Cells treated with the cell-permeable DAG analogue 1-oleoyl-2-acetyl glycerol to activate PKC displayed approximately two-fold increases of fibronectin, laminin, and type IV collagen mRNA levels after normalization against actin.
(5) We observed a 30-45% increase in DAG in rat gastrocnemius and diaphragm muscles, 5-15 min after intramuscular or intravenous injections of 1-3 U of insulin per rat, doses which would be expected to activate insulin receptors more fully.
(6) Concomitantly, an increase of inositol phosphates and diacylglycerol (DAG) production was observed.
(7) The accumulation of [14C]C20:4-DAG (lower in ET than in saline-infused rats) was paralleled by a decrease in phosphatidylinositol (PI) labelling, whereas phosphatidic acid showed a transient increase by 5 min in saline- but not in ET-infused rats.
(8) To determine the role of the DAG produced upon bombesin stimulation, we examined the effects of another activator of protein kinase C, the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).
(9) It is concluded that carbachol increases [Ca2+]i by facilitating Ca2+ entry through L-type Ca2+ channels via a 1,2-diacylglycerol (DAG)-protein kinase C (PKC)-dependent pathway while quisqualate mobilizes Ca2+ from inositol 1,4,5-trisphosphate (IP3)-sensitive stores.
(10) In order to characterize the properties of the glyceroglycolipid membranes, ESR spectroscopic studies were carried out with an acyl spin-labeled galactosyl ceramide (SL-GC) or a headgroup spin-labeled phospholipid (SL-6-DPPA) in 1,2-dipalmitoyl[beta-cellobiosyl-(1'---3)]glycerol (Cel-DAG) liposomal membranes.
(11) The E. coli dgkA locus which contains the coding sequences for DAG kinase was subcloned into an eukaryotic expression vector, pMT2.
(12) The mean residence time for pharmacologically active molecules in the body was six times shorter for DAG (1.9 hr) than for DBD (11.4 hr).
(13) These data suggest that PKC is a mediator in the generation of DAG.
(14) These results suggest that DAG accumulation is involved in the potentiating effect of A23187 on CCh-stimulated amylase secretion.
(15) It is concluded that insulin-dependent PDH activation, PIG hydrolysis, and IG and DAG generation are mediated by the wild-type but not by the mutated insulin receptor of Val996.
(16) Since most alloantibodies detected only by 2SP-IAT or LISS-DAG were of doubtful clinical significance, and these techniques produced a high number of unwanted positive reactivities, we conclude that 2SP-IAT and LISS-DAG are not appropriate for the pretransfusion screening for unexpected antibodies.
(17) 261, 8597-8600), lipase from Rhizopus arrhizus selectively degraded the 1-acyl-containing species (DAG), but the ether lipid (EAG) was resistant and was identified and quantified after thin layer chromatography separation.
(18) 1-Oleoyl-2-acetylglycerol, a synthetic DAG analog, stimulated endothelial cell DNA synthesis in a concentration-dependent manner.
(19) Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
(20) Addition of PRL to hepatocyte cultures significantly increased [3H]-glycerol incorporation into DAG within 5 minutes which was followed by a loss of cytosolic PKC activity by 10 minutes.
Lock
Definition:
(n.) A tuft of hair; a flock or small quantity of wool, hay, or other like substance; a tress or ringlet of hair.
(n.) Anything that fastens; specifically, a fastening, as for a door, a lid, a trunk, a drawer, and the like, in which a bolt is moved by a key so as to hold or to release the thing fastened.
(n.) A fastening together or interlacing; a closing of one thing upon another; a state of being fixed or immovable.
(n.) A place from which egress is prevented, as by a lock.
(n.) The barrier or works which confine the water of a stream or canal.
(n.) An inclosure in a canal with gates at each end, used in raising or lowering boats as they pass from one level to another; -- called also lift lock.
(n.) That part or apparatus of a firearm by which the charge is exploded; as, a matchlock, flintlock, percussion lock, etc.
(n.) A device for keeping a wheel from turning.
(n.) A grapple in wrestling.
(v. t.) To fasten with a lock, or as with a lock; to make fast; to prevent free movement of; as, to lock a door, a carriage wheel, a river, etc.
(v. t.) To prevent ingress or access to, or exit from, by fastening the lock or locks of; -- often with up; as, to lock or lock up, a house, jail, room, trunk. etc.
(v. t.) To fasten in or out, or to make secure by means of, or as with, locks; to confine, or to shut in or out -- often with up; as, to lock one's self in a room; to lock up the prisoners; to lock up one's silver; to lock intruders out of the house; to lock money into a vault; to lock a child in one's arms; to lock a secret in one's breast.
(v. t.) To link together; to clasp closely; as, to lock arms.
(v. t.) To furnish with locks; also, to raise or lower (a boat) in a lock.
(v. t.) To seize, as the sword arm of an antagonist, by turning the left arm around it, to disarm him.
(v. i.) To become fast, as by means of a lock or by interlacing; as, the door locks close.
Example Sentences:
(1) A bouncy function has now been incorporated into a knee of the semi-automatic knee lock design in a pilot laboratory trial involving six patients.
(2) The only other black woman I see in the building: washing dishes behind a door that was supposed to have been locked.
(3) In contrast, 1:1 phase locking characterized the electrical correlates of the duodenal activity front.
(4) When you hear the name Jesus, is the first image that comes to mind a dewy-eyed pretty boy with flowing locks?
(5) The commonly used line-to-line reaming technique was compared to an underreaming technique using both four-fifths and one-third porous-coated anatomic medullary locking (AML) implants.
(6) Andrew and his wife Amy belong to Generation Rent, an army of millions, all locked out of home ownership in Britain.
(7) While the Spielberg of popular myth is Mr Nice Guy, Lean was known as an obsessive, cantankerous tyrant who didn't much like actors and was only truly happy locked away in the editing suite.
(8) One top Republican official told the Guardian the party has for months been locked in secret talks with TV networks about how – or whether – it will fit all the candidates onstage for the primary debates.
(9) We develop an analogy between the steric hindrance among receptors detecting randomly placed haptens and the temporary locking of a Geiger counter that has detected a radioactive decay.
(10) On Wednesday, managing director Mike Devereux also flagged that the company's future in the country was not certain if government funding was not locked in over a long period.
(11) The violence led to the temporary suspension of the council's monthly meeting with some staff at one stage locked in rooms to ensure their safety.
(12) There have been reports of difficulties with the seating and locking of the vaporisers which can cause a leak and failure of vapour delivery.
(13) Such mutations lead to a major reduction in the rate of GTP hydrolysis by the complex of ras p21 and the GTPase activating protein (GAP) and lock the protein in a growth-promoting state.
(14) He was a fixture at Trump rallies, where he met chants of “Lock her up” against Hillary Clinton with a smile.
(15) No doubt New Labour ministers would regard such moves as protectionism, locked as they are in a discredited free-market mindset.
(16) So-called "structured" savings accounts promoted heavily by banks and building societies promise savers extra interest if they lock their money away for at least five years.
(17) Palmer sought to clarify his statements on Tuesday, and said they were aimed at the company he is currently locked in a dispute with, and not the broader Chinese population.
(18) Foveal exposures that did not produce an immediately visible lesion did not produce measurable changes in VEP response lock-in time.
(19) Scream Queens is the kind of show where you discover a secret locked room in the basement in one scene and then we find out exactly what is in the room three scenes later.
(20) In a group of the MS-DB units with stable background theta bursts the typical response consisting of entrainment of the phase-locked theta cycles was changed neither by physostigmine, nor by cholinergic-blocking drugs (scopolamine and atropine).