(v. t.) To cut into jags or points; to slash; as, to dag a garment.
(v. i.) To be misty; to drizzle.
Example Sentences:
(1) In general, optimal DAGAT activity in vitro was observed when long-chain unsaturated acyl-CoAs and diacylglycerols (DAGs) containing long acyl chains were used as substrates for in vitro TAG synthesis (although 1,2-didecanoin was also very effective).
(2) Incubation of microsomes with CDP-DAG of different fatty acid composition results in quantitative and qualitative differences in lysoPI formation.
(3) We now report that two synthetic diacylglycerols (DAG) replicate the stimulatory and inhibitory effects of TPA on frog skin.
(4) The distribution of PKC returned to control values by 24 h. High glucose did not stimulate phosphoinositide hydrolysis, as evidenced by the absence of an increase in the water-soluble inositol phosphates, indicating that DAG was not generated through the action of a phosphoinositide-specific phospholipase C. Cells treated with the cell-permeable DAG analogue 1-oleoyl-2-acetyl glycerol to activate PKC displayed approximately two-fold increases of fibronectin, laminin, and type IV collagen mRNA levels after normalization against actin.
(5) We observed a 30-45% increase in DAG in rat gastrocnemius and diaphragm muscles, 5-15 min after intramuscular or intravenous injections of 1-3 U of insulin per rat, doses which would be expected to activate insulin receptors more fully.
(6) Concomitantly, an increase of inositol phosphates and diacylglycerol (DAG) production was observed.
(7) The accumulation of [14C]C20:4-DAG (lower in ET than in saline-infused rats) was paralleled by a decrease in phosphatidylinositol (PI) labelling, whereas phosphatidic acid showed a transient increase by 5 min in saline- but not in ET-infused rats.
(8) To determine the role of the DAG produced upon bombesin stimulation, we examined the effects of another activator of protein kinase C, the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).
(9) It is concluded that carbachol increases [Ca2+]i by facilitating Ca2+ entry through L-type Ca2+ channels via a 1,2-diacylglycerol (DAG)-protein kinase C (PKC)-dependent pathway while quisqualate mobilizes Ca2+ from inositol 1,4,5-trisphosphate (IP3)-sensitive stores.
(10) In order to characterize the properties of the glyceroglycolipid membranes, ESR spectroscopic studies were carried out with an acyl spin-labeled galactosyl ceramide (SL-GC) or a headgroup spin-labeled phospholipid (SL-6-DPPA) in 1,2-dipalmitoyl[beta-cellobiosyl-(1'---3)]glycerol (Cel-DAG) liposomal membranes.
(11) The E. coli dgkA locus which contains the coding sequences for DAG kinase was subcloned into an eukaryotic expression vector, pMT2.
(12) The mean residence time for pharmacologically active molecules in the body was six times shorter for DAG (1.9 hr) than for DBD (11.4 hr).
(13) These data suggest that PKC is a mediator in the generation of DAG.
(14) These results suggest that DAG accumulation is involved in the potentiating effect of A23187 on CCh-stimulated amylase secretion.
(15) It is concluded that insulin-dependent PDH activation, PIG hydrolysis, and IG and DAG generation are mediated by the wild-type but not by the mutated insulin receptor of Val996.
(16) Since most alloantibodies detected only by 2SP-IAT or LISS-DAG were of doubtful clinical significance, and these techniques produced a high number of unwanted positive reactivities, we conclude that 2SP-IAT and LISS-DAG are not appropriate for the pretransfusion screening for unexpected antibodies.
(17) 261, 8597-8600), lipase from Rhizopus arrhizus selectively degraded the 1-acyl-containing species (DAG), but the ether lipid (EAG) was resistant and was identified and quantified after thin layer chromatography separation.
(18) 1-Oleoyl-2-acetylglycerol, a synthetic DAG analog, stimulated endothelial cell DNA synthesis in a concentration-dependent manner.
(19) Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
(20) Addition of PRL to hepatocyte cultures significantly increased [3H]-glycerol incorporation into DAG within 5 minutes which was followed by a loss of cytosolic PKC activity by 10 minutes.
Sharpen
Definition:
(a.) To make sharp.
(a.) To give a keen edge or fine point to; to make sharper; as, to sharpen an ax, or the teeth of a saw.
(a.) To render more quick or acute in perception; to make more ready or ingenious.
(a.) To make more eager; as, to sharpen men's desires.
(a.) To make more pungent and intense; as, to sharpen a pain or disease.
(a.) To make biting, sarcastic, or severe.
(a.) To render more shrill or piercing.
(a.) To make more tart or acid; to make sour; as, the rays of the sun sharpen vinegar.
(a.) To raise, as a sound, by means of a sharp; to apply a sharp to.
(v. i.) To grow or become sharp.
Example Sentences:
(1) This paper employs a rhetorical form designed to clarify and sharpen the focus of the very special stance required--which must be painstakingly learned under careful supervision--in order to effectively tune in to communications coming from the unconscious of the patient.
(2) Although not all reported unconventional applications of antimicrobial agents remain in use, sharpening awareness of their multifaceted actions should encourage broader understanding of all agents traditionally confined to specific uses.
(3) The surprise return of Saleh last month, after recovering in Saudi Arabia from an assassination attempt, has plunged the country into deeper uncertainty and sharpened the differences between pro- and anti-government camps.
(4) Ear-piercing techniques include needles, safety pins, sharpened studs, and self-piercing kits.
(5) The factory sharpened scalers exhibited metallic extensions from the lateral surface (wire edges).
(6) Disruption of visual activity, either by blocking activity with intraocular tetrodotoxin (TTX; Schmidt and Edwards, 1983) or by synchronizing activity with strobe illumination (Schmidt and Eisele, 1985), disrupts the sharpening process: the map is correctly oriented but the multiunit receptive fields at each point average 25-40 degrees in diameter.
(7) NaOH or 1 M acetate buffer at pH 6.0 sharpened e.p.r.
(8) The addition of 1 mM MgATP leads to a sharpening of the length distribution around 1.5 micron without change in the 16 nm diameter.
(9) During this period, the intensity of transcription in presomitic and somitic mesoderm declines relative to that in the overlying neural ectoderm, and the transcription boundary within the presumptive hindbrain region sharpens.
(10) The overall sense is of YouTube sharpening its focus on its most popular content, both in terms of individual channels and entire categories.
(11) The day before the murder you Adebolajo bought five knives and a knife sharpener – which you used to sharpen some of the knives in preparation for their use in the murder.
(12) The sharpening dispute over the Senkaku islands, known as Diaoyu in China , is the most recent product of this old narrative of violence, hatred, fear and grief that continues, sporadically, to obstruct both nations in their efforts to forge a more stable, trusting relationship.
(13) Hagan himself used to work in the car industry, and brought a similar shift operation and level of automation to the housing factory to sharpen up the process.
(14) Jam is often used but this can make it too sweet – if you do use jam try mixing in a little lemon juice to sharpen things up.
(15) By the time the latest spat came before the FCC, Karr argues, net activists had sharpened their tactics and raised their game.
(16) To improve the definitions, eliminate overlapping diagnostic categories, and sharpen the fuzzy boundaries that contribute substantially to limited reproducibility, we suggest: (1) the categories of astrocytoma nos, fibrillary astrocytoma, and protoplasmic astrocytoma be collapsed into a single category of astrocytoma; (2) the diagnostic category of desmoplastic medulloblastoma be combined with medulloblastoma; and (3) the criteria for anaplasia should be further refined to include quantification of critical histologic features, e.g., agreed upon operational definitions for amount of cell density, number of mitoses and pleomorphism for anaplastic astrocytoma and anaplastic ependymoma.
(17) Rather than pointing fingers or assigning blame, let’s use this occasion to expand our moral imaginations, to listen to each other more carefully, to sharpen our instincts for empathy and remind ourselves of all the ways that our hopes and dreams are bound together … If this tragedy prompts reflection and debate – as it should – let’s make sure it’s worthy of those we have lost.
(18) When sharpened with citrus and lubricated with olive oil, this is a real delight.
(19) His friend Dingle Foot drafted an editorial that David then sharpened up, inserting phrases that summed up his outlook: 'We had not realised that our government was capable of such folly and crookedness...It is no longer possible to bomb countries because you fear that your trading interests will be harmed...this new feeling for the sanctity of human life is the best element in the modern world.'
(20) The temperature profiles of turbidity (TP tau) of the cyclododecapeptide are analogous to those of the polyhexapeptide where increases in concentration lead to translations of the profiles to lower temperature without sharpening of the transition.