(n.) The state of being deficient; inadequacy; want; failure; imperfection; shortcoming; defect.
Example Sentences:
(1) The goals of treatment are the restoration of normal gut peristalsis and the correction of nutritional deficiencies.
(2) These deficiencies in the data compromise HIV surveillance based on diagnostic testing, and supplementary bias-free data are needed.
(3) Congenitally deficient plasmas were used as the substrate for the measurement of procoagulant activities in a one-stage clotting assay.
(4) In contrast, idiopathic GH deficient girls have an onset of puberty and PHV nearer to a normal chronological age and at an early bone age.
(5) The ACTH deficiency recovered spontaneously, with normal cortisol responses to depot Synacthen (greater than 1380 at 6 h) and hypoglycemia (peak, 590) 14 and 18 months postpartum, respectively.
(6) One hundred and twelve dogs, including twenty C3-deficient dogs, were studied over a period of 6 years.
(7) Dietary factors affect intestinal P450s markedly--iron restriction rapidly decreased intestinal P450 to beneath detectable values; selenium deficiency acted similarly but was less effective; Brussels sprouts increased intestinal AHH activity 9.8-fold, ECOD activity 3.2-fold, and P450 1.9-fold; fried meat and dietary fat significantly increased intestinal EROD activity; a vitamin A-deficient diet increased, and a vitamin A-rich diet decreased intestinal P450 activities; and excess cholesterol in the diet increased intestinal P450 activity.
(8) Paired tolbutamide and glucose infusions using a square wave technique demonstrated that although early phase insulin secretion is dimished in the fetus, this is not due to an absolute deficiency of stored insulin.
(9) A significant association between G6PD deficiency and hemoglobin S correlated with previous studies on similar samples from the general population.
(10) We describe 10 patients with cerebral venous thrombosis: two had protein S deficiency, one had protein C deficiency, one was in early pregnancy, and there was a single case of each of the following: dural arteriovenous malformation, intracerebral arteriovenous malformation, bilateral glomus tumours, systemic lupus erythematosus, Wegener's granulomatosis, non-Hodgkin's lymphoma.
(11) A newborn presenting with persistent umbilical stump bleeding should be screened for factor XIII deficiency when routine coagulation tests prove normal.
(12) Recognition of this deficiency in our knowledge spurred a belated explosion of research that began with an exploration of the fine structure of the mesothelium.
(13) C. parasitica mutant strains deficient in the production of endothiapepsin (eapA-) were constructed using a gene-replacement strategy.
(14) Clinicians should be aware of this new and unusual association of a cerebral glioma and acquired immune deficiency syndrome.
(15) We have previously reported the isolation of a genomic clone encoding human liver-specific peroxisomal alanine:glyoxylate aminotransferase (AGT, EC 2.6.1.44), the deficient enzyme in primary hyperoxaluria type 1 (PH1) (P. E. Purdue, Y. Takada, and C. J. Danpure, J.
(16) Natural killer (NK) cell activity was assessed in the peripheral blood of 20 patients with growth hormone (GH) deficiency due to a hypothalamic deficit of GH-releasing hormone (GHRH).
(17) The results show that of 543 subjects with AA haemoglobin, 106 (19.5%) were G-6-PD deficient and of 93 individuals with AS haemoglobin 13 (14.0%).
(18) Basal plasma levels of oxytocin were found to be low in sodium-deficient adrenalectomized rats and in intact animals treated daily with desoxycorticosterone acetate, both of which groups drank large amounts of NaCl solution, whereas basal plasma levels of arginine vasopressin were neither stimulated nor suppressed.
(19) ACTH also suppressed aldosterone biosynthesis in rats kept on a sodium-deficient diet.
(20) The duodenal mucosa of genotypically normal iron replete and iron deficient mice and mice with sex-linked (sla) and microcytic anemias (mk) was examined for the presence of iron-binding proteins.
Pellagra
Definition:
(n.) An erythematous affection of the skin, with severe constitutional and nervous symptoms, endemic in Northern Italy.
Example Sentences:
(1) On the basis of that work Joseph Goldberger developed a diet which produced a condition analogous to pellagra in dogs.
(2) Pellagra diagnosis was made on the basis of the typical clinical skin picture, and low urinary excretion of N'methylnicotinamide and N'methyl-2-pyridone-5-carboxamide (reduced by 70 and 80%, respectively, compared with controls).
(3) These results suggest that Zn interacts with niacin metabolism in alcoholic patients with pellagra through a probable mediation by vitamin B-6.
(4) D-xylose absorption tests and jejunal morphology have been shown to be unaltered in 12 African patients with pellagra when compared with normal values for Zambian Africa adults; that result is contrary to two previous investigations in India and Egypt respectively.
(5) 231 cases of pellagra among 8,000 consulting patients has been observed from May 1977 to June 1978 in the Dermatological Dispensary of the Hospital G.E.C.A.-Mines of Lumbumbashi (Zaire).
(6) Two types of pathologic state are unquestionably the concern of vitaminotherapy: More or less specific and intense vitamin deficiencies: Rickets, scurvy, beri beri, pellagra, vitamin deficiency related to alcohol consumption, polyneuritis, encephalopathy, malabsorption, mucoviscidosis, etc.
(7) Pellagra is a classical disease rarely seen in this country.
(8) Pellagra in the human is characterized by the clinical "three D's," namely, dermatitis, diarrhea, and dementia.
(9) Dermatoses with photosensitivity are divided into three groups: photo-aggravated dermatoses (solar herpes, lupus erythematosus), photosensitivity caused by protective system defect (xeroderma pigmentosum), and photosensitivity caused by metabolic defects (porphyrias, pellagra).
(10) His CNS lesions were composed of disseminated necrotic foci in the cerebral cortices with many Alzheimer type II astrocytes, pachymeningitis hemorrhagica interna, and lesions similar to pellagra and Wernicke encephalopathy.
(11) The nicotinamide nucleotide concentrations in the erythrocytes of subjects suffering from pellagra (pellagrins) were not lower than those in normal subjects, but the ability of erythrocytes to synthesize these nucleotides in vitro was significantly lower in pellagrins.
(12) In pellagra, symmetric keratotic areas on the face are always accompanied by lesions elsewhere on the body.
(13) It is concluded that pellagra per se does not alter intestinal structure or monosaccharide absorption.
(14) It is noted that some of the manifestations of prolonged sleep deprivation are similar to changes seen in pellagra.
(15) We evaluated the effects of SMS 201-995 in 14 such patients, 12 with diarrhea, 8 with flushing, 3 with wheezing, one with tricuspid valve incompetence, 6 with facial telangiectasia, 3 with a pellagra type dermatosis and one with myopathy.
(16) Tryp deficiency caused classical manifestations of pellagra although niacin intake was in excess of normal requirements.
(17) The first symptom of the disease was a serious and prolonged pellagra-like photodermatitis.
(18) Photosensitivity has also been associated with pellagra.
(19) The condition manifests as a pellagra-like skin rash within 8 weeks after birth, with signs of cerebellar ataxia and developmental retardation.
(20) A patient who was treated with isoniazid and who developed pellagra is presented.