(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Disastrous
Definition:
(a.) Full of unpropitious stellar influences; unpropitious; ill-boding.
(a.) Attended with suffering or disaster; very unfortunate; calamitous; ill-fated; as, a disastrous day; a disastrous termination of an undertaking.
Example Sentences:
(1) However, we have observed cracks on the Dacron fibers, fiber fracture, fiber protrusion, and poor attachment to the diaphragm, which can cause potentially disastrous complications.
(2) This proposal is a purely partisan move that will backfire on the government disastrously.” The Green party accused Osborne of making “efforts to limit the democratic scrutiny of his austerity agenda”.
(3) They moved to shore up May’s position after a weekend of damaging leaks and briefings from inside the cabinet, believed to be fuelled by some of those jostling to succeed the prime minister after her disastrous election result.
(4) To leave the Euro, says Clarke, would be "disastrous" for the Greeks.
(5) There are no easy answers to these problems, but we must recognise that a muri approach is potentially disastrous.
(6) Prior planning of the coverage before the excision pays dividends by preventing disastrous complications.
(7) But Frank argues the disastrous attempt at curbing markets through currency reform in 2009 has shown the cost of turning back from change.
(8) Getting them to safety is now vital.” While the EU’s hotspots approach improved the fingerprinting and security vetting of migrants, the auditors said that funding and relocation “bottlenecks” had extended the detention of migrants, with disastrous consequences for children.
(9) He argued that it was vital that we “should give the people of this country a chance to decide”, and that “[the nation was witnessing] a continuation of that old and disastrous system where a few men in charge of the state, wielding the whole force of the state, make secret engagements and secret arrangements, carefully veiled from the knowledge of the people…” This, and a lot more little-known information on the road to the first world war is given in Douglas Newton’s book The Darkest Days .
(10) However, the shadow foreign secretary, Douglas Alexander , is adamant Labour could not afford to spend the first two years of government wrestling with a referendum on Europe, pointing to the energy it had expended on the near-disastrous no campaign for the Scotland independence vote.
(11) The disastrous launches of SimCity and Battlefield 4 , the confining and somewhat invasive nature of the publisher’s Origin digital gaming platform and the voraciously monetised smartphone version of Dungeon Keeper, have kicked further dents in its reputation.
(12) Austin said: "Since the House of Lords judgment, the police have increased their use of the tactic of kettling, with disastrous consequences for the right to peaceful protest and the safety of protesters.
(13) By trading Holiday for Noel, the 76ers are effectively ending the Andrew Bynum experiment after one disastrous year and seem likely to start a rebuilding process.
(14) Casting a vote for any of the alternative party or independent candidates in November could have truly disastrous effects.
(15) If she learns anything from this disastrous outing, I hope itʼs that if sheʼs going to allow the music industry to play her as a sex object, she needs to at least own it.
(16) Mike Griffiths, headteacher at Northampton School for Boys, the first high-performing school to become an academy after Gove became secretary of state for education in May 2010, said the issue would not only have a potentially disastrous effect on pupils who failed to get a necessary C grade in English, but also on those hoping to study at elite institutions who fell short of getting As or A*s. "If you are applying to a Russell Group university, for instance, to study medicine or law, and all the applicants have a string of A*s, they will look back to the GCSEs and see a B in English – and that could decide your fate," he said.
(17) As well as causing a breakdown in trust between the north and the capital, and between communities in the north, caused by the occupation, the conflict has been economically disastrous.
(18) "People forget that I discussed two types of disaster in my book: disastrous developments and disastrous failures to develop."
(19) In 1993, at the Branch Davidian religious compound outside Waco, Texas, the Bureau of Alcohol, Tobacco and Firearms didn’t wait for the sect leader, David Koresh, to leave before attempting to arrest him and got into a gun battle that claimed 10 victims and led to a disastrous 51-day siege culminating in dozens more deaths.
(20) Lord of the Rings made him the doomed anti-hero , he was easily the best thing in the disastrous Troy, giving Odysseus guile, wit and that familiar, rough-edged charm, and he terrified TV viewers as property developer John Dawson in the dark and brilliant Red Riding .