(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Fast
Definition:
(v. i.) To abstain from food; to omit to take nourishment in whole or in part; to go hungry.
(v. i.) To practice abstinence as a religious exercise or duty; to abstain from food voluntarily for a time, for the mortification of the body or appetites, or as a token of grief, or humiliation and penitence.
(v. i.) Abstinence from food; omission to take nourishment.
(v. i.) Voluntary abstinence from food, for a space of time, as a spiritual discipline, or as a token of religious humiliation.
(v. i.) A time of fasting, whether a day, week, or longer time; a period of abstinence from food or certain kinds of food; as, an annual fast.
(v.) Firmly fixed; closely adhering; made firm; not loose, unstable, or easily moved; immovable; as, to make fast the door.
(v.) Firm against attack; fortified by nature or art; impregnable; strong.
(v.) Firm in adherence; steadfast; not easily separated or alienated; faithful; as, a fast friend.
(v.) Permanent; not liable to fade by exposure to air or by washing; durable; lasting; as, fast colors.
(v.) Tenacious; retentive.
(v.) Not easily disturbed or broken; deep; sound.
(v.) Moving rapidly; quick in mition; rapid; swift; as, a fast horse.
(v.) Given to pleasure seeking; disregardful of restraint; reckless; wild; dissipated; dissolute; as, a fast man; a fast liver.
(a.) In a fast, fixed, or firmly established manner; fixedly; firmly; immovably.
(a.) In a fast or rapid manner; quickly; swiftly; extravagantly; wildly; as, to run fast; to live fast.
(n.) That which fastens or holds; especially, (Naut.) a mooring rope, hawser, or chain; -- called, according to its position, a bow, head, quarter, breast, or stern fast; also, a post on a pier around which hawsers are passed in mooring.
(n.) The shaft of a column, or trunk of pilaster.
Example Sentences:
(1) Comparison of the S100 alpha-binding protein profiles in fast- and slow-twitch fibers of various species revealed few, if any, species- or fiber type-specific S100 binding proteins.
(2) A leg ulcer in a 52-year-old renal transplant patient yielded foamy histiocytes containing acid-fast bacilli subsequently identified as a Runyon group III Mycobacterium.
(3) Madrid now hopes that a growing clamour for future rescues of Europe's banks to be done directly, without money going via governments, may still allow it to avoid accepting loans that would add to an already fast-growing national debt.
(4) Diphenoxylate-induced hypoxia was the major problem and was associated with slow or fast respirations, hypotonia or rigidity, cardiac arrest, and in 3 cases cerebral edema and death.
(5) Two hours after refeeding rats fasted for 48 h, ODC activity increased 40-fold in mucosa from the intact jejunum and 4-fold in the mucosa of the bypassed segments.
(6) Five of them had a fast-moving Eco RI fragment 5.6 kb long that hybridized with zeta-specific probe but not with alpha-specific probe.
(7) A previous study, on grade IV astrocytomas, compared a combination of photons and fast neutron boost to photons only, both treatments being delivered following a concentrated irradiation schedule.
(8) J., 4 (1985) 1709-1714) and fast pH changes were applied with a technique developed by Davies et al.
(9) Glucose metabolic rates during control and reperfusion were unchanged for hearts from fasted rats, but decreased for hearts from fed rats during reperfusion.
(10) Brewdog backs down over Lone Wolf pub trademark dispute Read more The fast-growing Scottish brewer, which has burnished its underdog credentials with vocal criticism of how major brewers operate , recently launched a vodka brand called Lone Wolf.
(11) Despite the nearly anaerobic state of the ascites tumor fluid in vivo, cancer cells suspended in this fluid oxidized FFA at least as fast as they do in vitro under aerobic conditions.
(12) Inhibition of fast axonal transport by an antibody specific for kinesin provides direct evidence that kinesin is involved in the translocation of membrane-bounded organelles in axons.
(13) A quantitative index of duodenogastric reflux was obtained in each case by determining the percentage of the injected dose of 99mTechnetium-DISIDA that was recovered by continuous aspiration of gastric juice in fasting subjects.
(14) Variations in light chain composition, particularly fast and slow myosin light chain 1, appeared to occur independently of the variations in heavy chain composition, suggesting that some myosin molecules consist of mixtures of slow- and fast-type subunits.
(15) These analyses were carried out on unfractionated culture fluids and on fractions obtained by fast protein liquid chromatography separation using Superose 6 gels.
(16) A more accurate fit of T1 data using a modified Lipari and Szabo approach indicates that internal fast motions dominate the T1 relaxation in glycogen.
(17) Normal rat soleus myosin has a major slow and a minor fast component due to two populations of muscle fibers.
(18) The effects of insulin on the renal handling of sodium, potassium, calcium, and phosphate were studied in man while maintaining the blood glucose concentration at the fasting level by negative feedback servocontrol of a variable glucose infusion.
(19) Plasma and red cell sorbitol concentrations, fasting plasma glucose, glycosylated hemoglobin (GHb) were evaluated in 30 diabetic patients and 42 normal subjects.
(20) Acid-fast bacilli were isolated from 3 out of 41 mice inoculoted with heat killed bacilli.