(superl.) Evil in great degree; dreadful; dismal; horrible; terrible; lamentable.
Example Sentences:
(1) Why is it so surprising to people that a boy like Chol, just out of conflict, has thought through the needs of his country in such a detailed way?” While Beah’s zeal is laudable, the situation in South Sudan is dire .
(2) It is that beautiful moment when the original Metamorphosis is destroyed so that it can be refashioned for a global community of readers in dire need of new forms of storytelling.
(3) In this investigation, reanalysis of responses to case vignettes obtained from 436 psychologists, psychiatrists, and internists revealed that on the issue of confidentiality management, these health care providers discriminate among cases involving: Premeditated harm to others, socially irresponsible acts with possible dire consequences to self or others, and minor theft.
(4) The report’s concluding chapters raised dire warning that the operations of contemporary child protection agencies were replicating many of the destructive dynamics of the Stolen Generations era.
(5) Tim Cook, the CEO of Apple, warned Barack Obama in public remarks this month that history had shown “sacrificing our right to privacy can have dire consequences”.
(6) Algeria had not scored a World Cup goal since they drew 1-1 with Northern Ireland at Mexico 1986, a run that took in five matches, including that dire 0-0 draw with England in Cape Town four years ago.
(7) Professor Lord Stern of the London School of Economics, the author of the influential Stern Report into the economics of climate change for the Treasury in 2006, warned that if the pattern continued, the results would be dire.
(8) High among the range of issues was the media dominance of the Globo group (whose journalists were chased away from demonstrations by an irate mob), inefficient use of public funds, forced relocations linked to Olympic real estate developments, the treatment of indigenous groups, dire inequality and excessive use of force by police in favela communities.
(9) Burrows had resigned as governor of Bank of Ireland, leaving the lender in dire straits, with big losses and mounting debt threatening its very survival.
(10) Yet the inability to get on in life is a now a major and growing problem for middle-class children and this group is in dire need of attention, it is expected to report.
(11) Vince Cable, their shadow chancellor, said: "The Liberal Democrats welcome the government's recognition that radical action is now needed, reflecting the dire and deteriorating position of the UK economy.
(12) Its willingness to ignore diplomatic convention and use its Kuala Lumpur embassy to conduct an extraterritorial assassination will be seen as setting a dire precedent that cannot be allowed to stand.
(13) What is clear, however, is that the reported escalation in fighting exacerbates the already dire humanitarian and human rights situation and the suffering of the Yemeni people,” said Ban’s spokesman, Farhan Haq.
(14) In a scene of young soldiers at rest for a few minutes at the front, he takes us into their heads: one full of dire forebodings, another singing, one trying to identify a bird on a tree – soldiers dreaming of girls’ breasts, dogs, sausages and poetry.
(15) Despite its own dire predictions on the potential impact of climate change , the government's impact assessment for Flood Re does not take account of " changing flood risk due to deterioration of existing flood defences [or] climate change".
(16) The situation is so dire the National Audit Office has warned that by 2020 schools will be worse funded than at any time since the mid-90s.
(17) John Macgregor, an aid worker who has been accompanying teams delivering food and water to Battambang, described the area as a vast inland sea where conditions are dire and malnutrition is common.
(18) But they are also the stuff of nightmares, because if an electricity grid is overwhelmed by demand, the consequences can be dire, as India discovered recently , when more than 700 million people were left without power.
(19) Thousands of jobs that would have been created will be lost and the knock-on effect will be so dire.
(20) While big businesses have enjoyed access to new couriers, Royal Mail itself eventually reached such a dire state that the Hooper report urged the government to rewrite the law to clarify that competition was a mixed blessing.
Ire
Definition:
(n.) Anger; wrath.
Example Sentences:
(1) An insulin response element (IRE) has been identified in the prolactin gene using chimeric plasmids in which prolactin promoter DNA directs expression of the bacterial chloramphenicol acetyltransferase gene.
(2) The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.
(3) Government officials drew the public’s ire after charging Manning with three counts of misconduct following the suicide attempt, including two which carried possible penalties of indefinite solitary confinement.
(4) In a prospective, blinded trial, 40 healthy adult subjects using six IRED thermometers with two techniques were examined in random sequence.
(5) On Wednesday, the ire of the marchers was focused on all those Lib Dems who blithely signed the NUS's anti-fees pledge ("I pledge to vote against any increase in fees in the next parliament and to pressure the government to introduce a fairer alternative" – yesterday, Nick Clegg limply said that he "should have been more careful" than to put his name to it).
(6) Oleg Sentsov should make new films, not count years in prison.” Facebook Twitter Pinterest Oleg Sentsov sings the Ukrainian national anthem as he is sentenced to 20 years in a Russian penal colony Sentsov attracted the ire of the Russian authorities after helping to organise a campaign protesting at Russia’s occupation and annexation of Crimea in March 2014.
(7) A deletion and reconstitution study was undertaken to address the possibility that regions of the ferritin gene and mRNA other than the IRE may be necessary for the production of the full range of iron regulation.
(8) Her predecessor, Nick Robinson, attracted similar ire by upsetting Scottish nationalists .
(9) Interestingly, the FRP which remains active at a given hemin concentration binds to the IRE with the same high affinity as untreated FRP.
(10) The results strongly suggest that HCV RNA carries an internal ribosome entry site (IRES).
(11) Among the 17 pancreatic cancer patients with elevated IRE, 10 underwent radical resection of the cancer but in none of the five patients with normal serum IRE could radical resection be carried out.
(12) In addition, a poor sequence context around AUG-11 results in increased initiation at one or more downstream AUG codons, indicative of leaky scanning or jumping by the ribosome from AUG-11 mediated by the EMCV IRES.
(13) Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase.
(14) Regulation in both instances is mediated by binding of a cytosolic protein to the IREs.
(15) Binding of the IRE-BP represses ferritin translation and represses degradation of the TfR mRNA.
(16) Yet in doing so it presents an angled mirror-polished cliff face of glass, which has been reflecting the sun straight across into the Lloyds offices across the road – the seminal "inside-out" machine that Rogers designed 30 years earlier – much to the ire of its tenants.
(17) The nations with the highest recorded levels include Colombia, Uganda, Afghanistan, India, Pakistan, Bangladesh and Nepal, with the south Asian countries in particular producing unforgettable images of disfigured women who have been assaulted with acid because they have rejected sexual advances or marriage proposals, or aroused jealousy, or in some way or other inconvenienced the patriarchy and aroused its ire.
(18) Artificial mono- and dicistronic mRNAs were prepared and used to identify the region that carried the IRES.
(19) Two melanotic human melanoma cell lines, IRE 1 and IRE 2, and the lymphoma- and leukaemia-derived cell lines Raji and K 562, were exposed to different concentrations (from 5 X 10(-3) M to 10(-5) M) of phenols, both substrates (s) and non-substrates (ns) of tyrosinase, in the presence or absence of the oxygen-radical-scavenger enzymes superoxide dismutase, catalase and peroxidase.
(20) Afterwards, she was "suddenly beautiful", and though the attention this brought was occasionally useful, mostly it was just a pain in the butt: the tiresome suggestions that she had only got on thanks to her appearance; the hurtful ire of that other great feminist, Betty Friedan, whose loathing of Steinem seemed mostly to be motivated by envy.