(n.) A sudden descent from rank or state, reputation or happiness; destruction; ruin.
Example Sentences:
(1) "The Mayans couldn't even predict their own downfall, could they?"
(2) The trial, originally expected to be staid, has exposed severe dysfunction within Bo's family and detailed the complicated tangle of allegiances and affairs that led to his downfall .
(3) The imposition of a poll tax on the Scots in 1989 contributed to Margaret Thatcher's downfall and all but wiped out Scottish Toryism.
(4) Mal Brough has vowed to stare down calls to resign over his role in the downfall of the former speaker Peter Slipper as the Labor party seeks to build pressure on Malcolm Turnbull for backing the special minister of state.
(5) Vladimir Putin painted a colourful picture of Russia's protesters on Thursday, describing them as agents of the west, attending useless demonstrations with condoms pinned to their chests as they sought the downfall of the motherland.
(6) Martin Kyrle, 79, a former mayor of Eastleigh and an active member of the Liberal Democrat party for 55 years, attributes Huhne's downfall to "a personal flaw.
(7) The 2012 rebellion was partly an unintended consequence of Muammar Gaddafi's downfall in Libya.
(8) Zhao, who was kept under intense surveillance at his home after his downfall and whose excursions and visitors were vetted, recorded his memoirs in such secrecy that even family members were unaware of his project.
(9) 'No,' he said with his usual solemn deliberation, 'it was the downfall of a great people and a great civilisation.'
(10) As ruthless as Liverpool were with their finishing, in particular the irrepressible Luis Suárez , who scored twice to take his tally for the season to 22, Stoke were guilty of some calamitous defending and contributed largely to their own downfall.
(11) More than 15 million Egyptians have signed a petition calling for the president's downfall, furious at Morsi's unilateralism and impatient at plummeting living standards.
(12) It never does | Lenore Taylor Read more Jamie Briggs resigned as the minister for cities and the built environment after “inappropriate” conduct towards a staffer during an official visit to Hong Kong and Mal Brough stood aside as special minister of state pending a police investigation into his alleged role in the downfall of Peter Slipper.
(13) Nokia's downfall came about because its Symbian smartphone software was awash with redundancy and complexity.
(14) Thatcher secured her position over more than a decade in power through a brutal belief in her own outlook, a belief that became sclerotic, and led to her downfall.
(15) Mal Brough faces fresh parliamentary pressure over his role in the downfall of the former speaker Peter Slipper , after his attempt to walk away from a key admission was undermined by 60 Minutes releasing the unedited interview exchange.
(16) Macmillan and Thatcher paid with their jobs for being too brutal; Blair's downfall at the hands of Brown's acolytes was, to some extent at least, a consequence of him not being brutal enough.
(17) Today Luzhkov named Medvedev's press secretary, Natalia Timakova, and a Kremlin ideologist, Vladislav Surkov, as plotters of his downfall.
(18) The downfall of Sepp Blatter and the disgraced Fifa president’s one-time heir apparent, Michel Platini , is all but complete after both were banned from football for eight years by the world governing body’s own ethics committee.
(19) An early example of such alteration was the conversion to desert of the rich Tigris and Euphrates valleys through erosion and salt accumulation resulting from faulty irrigation practices that caused the downfall of the great Mesopotamian civilization.
(20) When asked if studio Fox were bothered by this he claimed: “They never said anything!” Despite his new project, Emmerich believes that “sequels are the downfall of films”.
Precipitous
Definition:
(a.) Steep, like a precipice; as, a precipitous cliff or mountain.
(1) The nuclear origin of the Ha antigen was confirmed by the speckled nuclear immunofluorescence staining pattern given by purified antibody to Ha obtained from a specific immune precipitate.
(2) The Fc fragment of this protein reacted with and was solubilized by the staphylococcal A protein which also precipitated the intact immunoglobulin.
(3) It could be demonstrated by radioimmune precipitation of virus labeled with[35S]methionine that all three polypeptides are specific for hog cholera virions.
(4) Nine of the in vivo synthesized early polypeptides can be precipitated specifically from infected cell extracts by antisera with specificity against early adenovirus proteins.
(5) Its pathogenesis, still incompletely elucidated, involves the precipitation of immune complexes in the walls of the all vessels.
(6) The usefulness of the proposed method is obvious in cases where the composition of a precipitate on LM scale is to be compared with the LM appearance of the surrounding tissue.
(7) After precipitation of plasma proteins by addition of methanol the samples are injected directly into the liquid chromatographic system.
(8) Thus Sephadex chromatography of the solution obtained by dissolving the antigen-antibody precipitate in these media repeatedly gave two peaks corresponding to anti-ovalbumin and ovalbumin.
(9) When AMT administration was discontinued 40 hrs before precipitation of withdrawal the withdrawal pattern occurred with unchanged intensity.
(10) Using a simple precipitation technique we observed that the serum concentrations of low density lipoproteins in healthy Africans were less than half the serum concentrations in healthy Europeans.
(11) There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier.
(12) Precipitating antibodies were found in both lines; they first appeared 7 days after inoculation in P-line birds and 14 days after inoculation in N-line birds, but thereafter there was no difference between the two genetic lines.
(13) The new technique, Surface Immune Precipitation (SIP), entails the application of an antigen sample droplet directly onto the surface of a gel containing antibody, the gel being supported by a reflecting substrate.
(14) In this study we have compared purified C4A and C4B with regard to their ability to prevent immune complex precipitation and to enhance the binding of both preformed and nascent immune complexes to the receptor CR1 on red cells.
(15) A lesser inhibitory effect (a decrease in the rate of precipitation) was observed when gallbladder bile was diluted but was lost after 10-fold dilution.
(16) The first step is the preparation of a globulin-enriched fraction by precipitation with ammonium sulfate at 50% saturation, or of an immune-complex-enriched fraction by precipitation with 5% polyethylene glycol 6000.
(17) DNase I microspheres were then introduced into the extracorporeal circuit which resulted in an acceleration of degradation of acid precipitable 125I-nDNA.
(18) The dramatic nationwide increase of primary and secondary syphilis in women has precipitated a dramatic rise in congenital syphilis.
(19) The translation of mRNA for S-adenosylmethionine decarboxylase was studied using a polyamine-depleted reticulocyte lysate supplemented with mRNA from rat prostate and the antiserum to precipitate the proteins corresponding to S-adenosylmethionine decarboxylase.
(20) Only heart rate correlated closely with the precipitation of angina.