(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
Heir
Definition:
(n.) One who inherits, or is entitled to succeed to the possession of, any property after the death of its owner; one on whom the law bestows the title or property of another at the death of the latter.
(n.) One who receives any endowment from an ancestor or relation; as, the heir of one's reputation or virtues.
(v. t.) To inherit; to succeed to.
Example Sentences:
(1) Antoine Comte, a lawyer for the Schloss heirs, said all the family wanted was the return of the painting.
(2) Diana of the sapphire eyes was rated more perfect than Botticelli's Venus and attracted Bryan Guinness, heir to the brewing fortune, as soon as she was out in society.
(3) They are most commonly described as conduct disordered and hyperactive, appear heir to a variety of deficits in verbal and abstract cognition, and perform more poorly in the academic environment.
(4) Another example is the death in 1817 of Princess Charlotte, in childbirth, which led to the scramble of George III's aging sons to marry and beget an heir to the throne.
(5) Museveni, who has held power for nearly three decades, has never said he sees his son as his political heir.
(6) Throughout his career he has continued to champion Crane, seeing him as the direct heir to Walt Whitman – Whitman being "not just the most American of poets but American poetry proper, our apotropaic champion against European culture" – and slayer of neo-Christian adversaries such as "the clerical TS Eliot" and the old New Critics, who were and are anathema to Bloom, unresting defender of the Romantic tradition.
(7) Her parents, Apiruj and Wanthanee Suwadee, were found guilty of violating Article 112 of Thailand’s criminal code which says anyone who “defames, insults or threatens the king, the queen, the heir-apparent or the regent” will be punished with up to 15 years in prison.
(8) The anointed heir, Xi Jinping , commanded less attention than former general secretary Jiang Zemin, seated next to current leader Hu Jintao.
(9) The two reformists Mr Mousavi and Mehdi Karroubi have sought to portray themselves as the true heirs of the Islamic revolution's spiritual leader, the late Ayatollah Khomeini, but this tactic has since worn thin and Khomeini's successor Ayatollah Ali Khamenei has stepped up his drive to paint Mousavi and Karroubi as western-run heretics.
(10) Welsh, but London-based, Jones's real offence to leftwingers - heirs to Nye Bevan - was to be a Blairite, "parachuted" into Blaenau Gwent.
(11) Revelations about Charles' power of consent come amid continued concern that the heir to the throne may be overstepping his constitutional role by lobbying ministers directly and through his charities on pet concerns such as traditional architecture and the environment.
(12) In the past, they were mostly wealthy British citizens seeking to hold their money outside the UK to avoid income tax and capital gains tax on their earnings, and to pass their wealth to heirs without inheritance tax.
(13) The spectacular ascent that saw him grace the cover of Newsweek as Asian of the Year and become the heir apparent of then prime minister Mahathir Mohamad was met with an equally spectacular crash in 1998, when the two fell out and Anwar was imprisoned for six years on corruption and sodomy charges, claims he repeatedly dismissed as politically motivated.
(14) The American heirs of a German-Jewish family have launched an unprecedented partnership with German state institutions to try to recover a vast art collection stolen by the Nazis.
(15) For seven years, the government has been fighting to prevent the disclosure of the letters – dubbed "black spider memos" because of the heir's handwriting.
(16) Tim Loughton, a Sussex MP, said it would be a "nonsense" to stop the heir to the throne talking to ministers as he had always come across as "well briefed and knowledgeable" in their meetings.
(17) But both Kennedy and Marks are now dead and Mossa said they had been unable to establish an obvious heir.
(18) Carter and the former leaders of Finland, Norway and Ireland were hoping for talks with Kim Jong-il and his son and heir apparent, Kim Jong-un.
(19) The gene termed heir-1 was localized to the neuroblastoma consensus deletion at 1p36.2-p36.12.
(20) Since Evans’ original request to see Charles’s letters, the government tightened up the Freedom of Information Act to provide an “absolute exemption” on all requests relating to the Queen and the heir to the throne.