(1) We have isolated several gamma-ray-induced mutants (GIMs) of the nontumorigenic HeLa x skin fibroblast hybrid CGL1 that were specifically selected for reexpression of IAP to further investigate the potential linkage between IAP regulation and the putative tumor suppressor locus.
(2) The relaxation rates of the exchangeable guanine imino protons (Gim) in H2O and in 90% D2O show that below 20 degrees C spin-lattice relaxation is exclusively from proton-proton magnetic dipolar interactions while proton-nitrogen interactions contribute about 30% to the spin-spin relaxation.
(3) These stimulate the processes of myeloid precursor proliferation directly (by means of lymphokines) and in cooperation with monocytes-macrophages of GIM.
(4) The relaxation rates of the Gim, C-H5, and C-H6 in B- and Z-form poly(dG-dC).poly(dG-dC) cannot be explained by assuming the DNA behaves as a rigid rod.
(5) Gonadotrophin-inhibiting material (GIM) was able to inhibit the binding of 125I-hCG to rat Leydig cells, suggesting that its inhibiting properties are due to its ability to complete for the hCG binding sites on Leydig cells.
(6) The observation that the spin-lattice relaxation is nonexponential and that the initial spin-lattice relaxation rate of the Gim, G-H8 and C-H6 protons depends on the selectivity of the exciting pulse shows that spin-diffusion dominates the spin-lattice relaxation.
(7) However, studies with tumor reconstitutes of the GIMs and transfection studies with an IAP complementary DNA expression vector indicate that high IAP expression alone is not sufficient to confer rapid tumor growth.
(8) Measurements of the 1H spin-lattice (R1) and spin-spin (R2) relaxation rates of the exchangeable thymine (Tim) and guanine (Gim) imino protons have been used to probe the internal dynamics of the B and Z-forms of poly[d(A-br5C).d(G-T)] and the mechanism of the B-Z transition.
(9) The GIMs have a wide range of cell morphology and level of IAP expression (nearly a factor of 40).
(10) The effect of GIM on hCG-induced adenylate cyclase activation and testosterone production was also studied.
(11) Conversion to the Z-form by addition of 4.5 M-NaCl dramatically reduces both the Tim and Gim exchange rates (estimated to be less than 2 s-1 at 70 degrees C).
(12) Binding of fluorescein isothiocyanate-tagged GIM to Leydig cells was also seen.
(13) The tumorigenicity of the GIMs was examined by s.c. injection into nude mice and all were found to be tumorigenic.
(14) The B and Z-forms of poly[d(A-br5C).d(G-T)] coexist in 4.6 M-NaCl at 45 degrees C. Due to slow exchange, two sets of Tim and Gim resonances are observed and can be assigned to the B and Z conformations (the chemical shifts are, respectively, Tim = 13.4, 14.1 p.p.m.
(15) In the second study a combination of music and imagery was examined by randomly assigning subjects to one of five groups: self-generated imagery with music (SIM), guided imagery with music (GIM), self-generated imagery without music (SI), guided imagery without music (GI), or no-treatment control.
(16) The tumor volume-doubling time is in the range of 4 to 8 days for all the cell lines; however, the lag time to reach 500 mm3 tumor volume was significantly longer when the GIM IAP activity was low (less than 20% relative activity), suggesting perhaps that there is a threshold level of IAP expression required for tumor formation and selection for high IAP expression in vivo.
(17) The increased number of committed precursor cells of erythro- and granulomonocytopoiesis, morphologically differentiated elements and enhancing colony-stimulating and erythropoietic activities of GIM cells origin were shown as well.
(18) At elevated temperature, R1 for both Tim and Gim in the B conformation is dominated by exchange with the solvent, with Tim exchanging more rapidly than Gim.
Rim
Definition:
(n.) The border, edge, or margin of a thing, usually of something circular or curving; as, the rim of a kettle or basin.
(n.) The lower part of the abdomen.
(v. t.) To furnish with a rim; to border.
Example Sentences:
(1) Two cases of posterior lumbar vertebral rim fracture and associated disc protrusion in adolescents are presented.
(2) Thirteen patients had had a posterior dislocation with an associated fracture of the femoral head located either caudad or cephalad to the fovea centralis (Pipkin Type-I or Type-II injury), one had had a posterior dislocation with associated fractures of the femoral head and neck (Pipkin Type III), two had had a posterior dislocation with associated fractures of the femoral head and the acetabular rim (Pipkin Type IV), and three had had a fracture-dislocation that we could not categorize according to the Pipkin classification.
(3) Both adiphenine.HCl and proadifen.HCl form more stable complexes, suggesting that hydrogen bonding to the carbonyl oxygen by the hydroxyl-group on the rim of the CD ring could be an important contributor to the complexation.
(4) If a tear is found, remove all unstable meniscal fragments, leaving a rim, if possible, especially adjacent to the popliteus recess, and then proceed to open cystectomy.
(5) But officials warned the rains may not reach the heart of the Rim fire.
(6) RIM has always struggled to explain to the authorities that, unlike most other companies, it technically cannot access or read the majority of the messages sent by users over its network.
(7) Early complications included disc entrapment against the ventricular wall in three cases, wedging of chorda between disc and valve rim in two and posterior perforation of the left ventricle in three patients.
(8) On CT scans the tumor thrombus usually appeared as an endoluminal filling defect surrounded by a rim of contrast material.
(9) The usual approach to the inferior orbit has been through a subciliary skin incision and dissection of a skin flap to the orbital rim.
(10) This permitted employment of cast combined crowns with wide perigingival metal rims to support the clasp dentures to make them look better when supplying 73 patients with partial removable dentures.
(11) Two patients had a second arthroscopy, and no evidence of instability of the peripheral rim was found.
(12) Fold the edges of the baking parchment down over the rim of the basin.
(13) Healing of rim widths to 5 mm can be obtained with these methods.
(14) In young people the basic histological pattern of clusters, composed of cores of chief cells with surrounding rims of sustentacular cells, has commonly superimposed on it prominence of the dark variant of chief cells.
(15) A hypointense vascular rim was noted on MR in seven of 13 extracanalicular acoustic tumors and in three of seven meningiomas.
(16) It was suggested that the differences in rim area were already present prior to the manifestation of the VFD.
(17) "I'm interested to see what RIM's new OS has in store, and hope I'll be able to sample some of its features on the 9900.
(18) MRI delineated discrete lesions, typical of cavernous angiomas, with a mixed hyperintense, reticulated, central core surrounded by a hypointense rim.
(19) When pointing to its importance in retention, it applies to the rim margins, its relation to the support and its role in the valve closure of the upper total prosthesis.
(20) Enhanced sonograms were classified into five patterns according to the relative changes of the echo levels between the tumor and the nontumorous parenchyma of the liver as a result of enhancement: hyperechoic change, isoechoic change, hypoechoic change with hyperechoic rim (rim sign), marginal spotty hyperechoic change, and internal spotty hyperechoic change.