(n.) A glucoside found in licorice root (Glycyrrhiza), in monesia bark (Chrysophyllum), in the root of the walnut, etc., and extracted as a yellow, amorphous powder, of a bittersweet taste.
Example Sentences:
(1) The pharmacokinetics of total and free prednisolone (PSL) in six healthy men, with or without pretreatment with oral glycyrrhizin (GL), was investigated to confirm whether oral administration of GL influences the metabolism of PSL in man.
(2) 3) Glycyrrhizin therapy is effective in the treatment of acute hemorrhagic cystitis and nephropathy due to AV and hepatic dysfunction.
(3) Glycyrrhizin treatment 2 hr prior to the administration of allyl formate also inhibited the development of the periportal hepatocellular necrosis.
(4) For this, rat hepatocytes were isolated, and incubated with antibody raised against rat liver cell membranes, and the effect of glycyrrhizin on their release of transaminase was investigated.
(5) Glycyrrhetic glycosides (GLA-GS), such as glycyrrhizin, were measured after acid hydrolysis to GLA by the enzyme immuno-antibody assay.
(6) Although there were large individual differences, it was found that GLA-GS was eliminated from the blood for the most part within 72 h. On the other hand, GLA reached maximum serum concentration at about 24 h after administration and in two of the five cases it was still detected in the blood even after 96 h. Urinary excretion of GLA was about 2% of the total dose of glycyrrhizin administered.
(7) The tested substances included two sulfated polysaccharides (lentinan sulfate and dextran sulfate) and a nonsulfated polysaccharide PSK, E-P-LEM, glycyrrhizin sulfate, and nucleoside analogues (AZT and DHT).
(8) The pharmacokinetic behavior of glycyrrhizin and its metabolites after oral and intravenous administration of glycyrrhizin to normal subjects was investigated.
(9) Therefore, paeoniflorin and glycyrrhizin, a main component of Shakuyaku and Kanzo, respectively, and glycyrrhetic acid, a metabolite of glycyrrhizin in vivo, were investigated for the steroid production in the rat ovary on the morning of proestrus.
(10) Neither licorice nor glycyrrhizin promoted growth or induced plaque formation.
(11) When 14C-labeled androstenedione was incubated with microsomal fraction of testicular or ovarian tissue, glycyrrhizin and glycyrrhetinic acid inhibited the conversion of androstenedione to testosterone, indicating that these compounds inhibit the activity of 17 beta-hydroxysteroid dehydrogenase (EC.
(12) Hydrocortisone and glycyrrhizine act as both stabilizers and labilizers of the lysosomes of liver.
(13) We isolated eight bacterial strains which could hydrolyze glycyrrhizin to glycyrrhezic acid.
(14) Intravenous chronic application (12 months) of glycyrrhizinic acid in the form of Remefa S in patients with chronic viral hepatitis B, is capable of exercising a positive effect on the evolution of the disease.
(15) Glycyrrhizin also inhibited acid phospholipase A2 with pH optimum of 4.5, which is thought to be present in the lysosomal membrane.
(16) The anti-viral mechanism of glycyrrhizin (GL) has been investigated by considering in vitro effects on polypeptide phosphorylation.
(17) These results demonstrate that both patients had a prolongation of the syndrome resembling primary aldosteronism except the low plasma aldosterone level about one month after the glycyrrhizin discontinuation.
(18) Since glycyrrhizin, glycyrrhetinic acid, and carbenoxolone have antiinflammatory properties and have recently been shown to interfere with steroid metabolism in renal tissues, their effects on 11 beta-HSD in human lung tissue have been tested.
(19) To clarify whether glycyrrhizin, the aqueous extract of licorice root and a drug for treatment of chronic active hepatitis, prevents the development of hepatic injury induced by carbon tetrachloride, allyl formate, and endotoxin, the present study was undertaken in rats.
(20) This study demonstrates a unique action of glycyrrhizin (GL) in bidirectionally controlling the growth response of lymphocytes stimulated through a receptor-bypassed pathway by calcium ionophore A23187 and phorbol 12-myristate 13-acetate (PMA).
Liquorice
Definition:
(n.) See Licorice.
Example Sentences:
(1) We have evaluated the effect of the synthetic liquorice derivative, carbenoxolone, on this enzyme complex.
(2) After a wide survey of the literature, the clinical and biological picture in four patients with chronic Liquorice ingestion and Pseudoaldosteronism syndrome is described.
(3) The town is also home to Svaneke Bolcher, where you can watch traditional Danish sweets being made, and Johan Bülow ’s inventive liquorice, which is now sold in shops such as Harvey Nichols and Fortnum & Mason.
(4) These results show that potentially serious metabolic effects may occur in some people who eat modest amounts of liquorice daily for less than a week.
(5) Both tragant sulfate, a pepsin inhibitor, and deglycyrrhizinized liquorice extract proved to be without prophylactic effect.
(6) We have previously demonstrated, in adrenalectomized male rats, that the liquorice derivative carbenoxolone (CS) can confer mineralocorticoid (MC)-like activity upon the glucocorticoid corticosterone (B) and amplify the Na(+)-retaining actions of aldosterone (Aldo) and deoxycorticosterone (DOC).
(7) A case of pseudo-hyperaldosteronism secondary to prolonged daily ingestion of liquorice is reported.
(8) They ate liquorice in daily doses of 100 g or 200 g (equivalent to 0-7-1-4 g glycyrrhizinic acid) for one to four weeks.
(9) The binding of agonists (liquorice derivatives) and antagonists (spironolactones and cyproheptadine) to Type I aldosterone binding sites was evaluated in human mononuclear leucocytes and compared with data previously obtained using kidney cytosol or kidney slices from adrenalectomized rats.
(10) A double-blind trial of deglycyrrhizinated liquorice was performed in 47 patients with active duodenal ulcer.
(11) Bassett's Liquorice Allsorts were created by accident in 1899, when salesman Charlie Thompson tripped up, mixing up all the different sweets he was carrying.
(12) Six geographically diverse samples of liquorice root contained similar (22.2-32.3 mg g-1) glycyrrhizin contents.
(13) These findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.
(14) The first example is liquorice root, its active principle carbenoxolone, and the drugs Biogastrone and Caved-S for the treatment of gastic, peptic and duodenal ulcers; the second example is the fruits of the milk thistle, its active principles silymarin and silybinin as well as the drug Legalon for the treatment of liver diseases.
(15) after liquorice ingestion) results in cortisol acting as a potent mineralocorticoid.
(16) No side effects of treatment were observed.Our study was not able to demonstrate any healing effect of the liquorice extract (Caved-S) on gastric ulcer.
(17) The patients were treated during two consecutive periods of four weeks each with either liquorice extract during the first period and placebo during the second or placebo during the first period and liquorice during the second.
(18) Her diva demands do not extend beyond the stage-door staff voluntarily leaving a hand-picked packet of her favourite black liquorice allsorts in her pigeonhole.
(19) When the activity of the enzyme is impaired (syndrome of apparent MC excess, liquorice or carbenoxolone administration), F acts as a MC and MC-hypertension with hypokalemia occurs.
(20) The dosage of the liquorice extract was 760 mg three times daily.