(n.) A glucoside found in licorice root (Glycyrrhiza), in monesia bark (Chrysophyllum), in the root of the walnut, etc., and extracted as a yellow, amorphous powder, of a bittersweet taste.
Example Sentences:
(1) The pharmacokinetics of total and free prednisolone (PSL) in six healthy men, with or without pretreatment with oral glycyrrhizin (GL), was investigated to confirm whether oral administration of GL influences the metabolism of PSL in man.
(2) 3) Glycyrrhizin therapy is effective in the treatment of acute hemorrhagic cystitis and nephropathy due to AV and hepatic dysfunction.
(3) Glycyrrhizin treatment 2 hr prior to the administration of allyl formate also inhibited the development of the periportal hepatocellular necrosis.
(4) For this, rat hepatocytes were isolated, and incubated with antibody raised against rat liver cell membranes, and the effect of glycyrrhizin on their release of transaminase was investigated.
(5) Glycyrrhetic glycosides (GLA-GS), such as glycyrrhizin, were measured after acid hydrolysis to GLA by the enzyme immuno-antibody assay.
(6) Although there were large individual differences, it was found that GLA-GS was eliminated from the blood for the most part within 72 h. On the other hand, GLA reached maximum serum concentration at about 24 h after administration and in two of the five cases it was still detected in the blood even after 96 h. Urinary excretion of GLA was about 2% of the total dose of glycyrrhizin administered.
(7) The tested substances included two sulfated polysaccharides (lentinan sulfate and dextran sulfate) and a nonsulfated polysaccharide PSK, E-P-LEM, glycyrrhizin sulfate, and nucleoside analogues (AZT and DHT).
(8) The pharmacokinetic behavior of glycyrrhizin and its metabolites after oral and intravenous administration of glycyrrhizin to normal subjects was investigated.
(9) Therefore, paeoniflorin and glycyrrhizin, a main component of Shakuyaku and Kanzo, respectively, and glycyrrhetic acid, a metabolite of glycyrrhizin in vivo, were investigated for the steroid production in the rat ovary on the morning of proestrus.
(10) Neither licorice nor glycyrrhizin promoted growth or induced plaque formation.
(11) When 14C-labeled androstenedione was incubated with microsomal fraction of testicular or ovarian tissue, glycyrrhizin and glycyrrhetinic acid inhibited the conversion of androstenedione to testosterone, indicating that these compounds inhibit the activity of 17 beta-hydroxysteroid dehydrogenase (EC.
(12) Hydrocortisone and glycyrrhizine act as both stabilizers and labilizers of the lysosomes of liver.
(13) We isolated eight bacterial strains which could hydrolyze glycyrrhizin to glycyrrhezic acid.
(14) Intravenous chronic application (12 months) of glycyrrhizinic acid in the form of Remefa S in patients with chronic viral hepatitis B, is capable of exercising a positive effect on the evolution of the disease.
(15) Glycyrrhizin also inhibited acid phospholipase A2 with pH optimum of 4.5, which is thought to be present in the lysosomal membrane.
(16) The anti-viral mechanism of glycyrrhizin (GL) has been investigated by considering in vitro effects on polypeptide phosphorylation.
(17) These results demonstrate that both patients had a prolongation of the syndrome resembling primary aldosteronism except the low plasma aldosterone level about one month after the glycyrrhizin discontinuation.
(18) Since glycyrrhizin, glycyrrhetinic acid, and carbenoxolone have antiinflammatory properties and have recently been shown to interfere with steroid metabolism in renal tissues, their effects on 11 beta-HSD in human lung tissue have been tested.
(19) To clarify whether glycyrrhizin, the aqueous extract of licorice root and a drug for treatment of chronic active hepatitis, prevents the development of hepatic injury induced by carbon tetrachloride, allyl formate, and endotoxin, the present study was undertaken in rats.
(20) This study demonstrates a unique action of glycyrrhizin (GL) in bidirectionally controlling the growth response of lymphocytes stimulated through a receptor-bypassed pathway by calcium ionophore A23187 and phorbol 12-myristate 13-acetate (PMA).
Root
Definition:
(v. i.) To turn up the earth with the snout, as swine.
(v. i.) Hence, to seek for favor or advancement by low arts or groveling servility; to fawn servilely.
(v. t.) To turn up or to dig out with the snout; as, the swine roots the earth.
(n.) The underground portion of a plant, whether a true root or a tuber, a bulb or rootstock, as in the potato, the onion, or the sweet flag.
(n.) The descending, and commonly branching, axis of a plant, increasing in length by growth at its extremity only, not divided into joints, leafless and without buds, and having for its offices to fix the plant in the earth, to supply it with moisture and soluble matters, and sometimes to serve as a reservoir of nutriment for future growth. A true root, however, may never reach the ground, but may be attached to a wall, etc., as in the ivy, or may hang loosely in the air, as in some epiphytic orchids.
(n.) An edible or esculent root, especially of such plants as produce a single root, as the beet, carrot, etc.; as, the root crop.
(n.) That which resembles a root in position or function, esp. as a source of nourishment or support; that from which anything proceeds as if by growth or development; as, the root of a tooth, a nail, a cancer, and the like.
(n.) An ancestor or progenitor; and hence, an early race; a stem.
(n.) A primitive form of speech; one of the earliest terms employed in language; a word from which other words are formed; a radix, or radical.
(n.) The cause or occasion by which anything is brought about; the source.
(n.) That factor of a quantity which when multiplied into itself will produce that quantity; thus, 3 is a root of 9, because 3 multiplied into itself produces 9; 3 is the cube root of 27.
(n.) The fundamental tone of any chord; the tone from whose harmonics, or overtones, a chord is composed.
(n.) The lowest place, position, or part.
(n.) The time which to reckon in making calculations.
(v. i.) To fix the root; to enter the earth, as roots; to take root and begin to grow.
(v. i.) To be firmly fixed; to be established.
(v. t.) To plant and fix deeply in the earth, or as in the earth; to implant firmly; hence, to make deep or radical; to establish; -- used chiefly in the participle; as, rooted trees or forests; rooted dislike.
(v. t.) To tear up by the root; to eradicate; to extirpate; -- with up, out, or away.
Example Sentences:
(1) After four years of existence, many evaluations were able to show the qualities of this system regarding root canal penetration, cleaning and shaping.
(2) The Bohr and Root effects are absent, although specific amino acid residues, considered responsible of most of these functions, are conserved in the sequence, thus posing new questions about the molecular basis of these mechanisms.
(3) Subdural tumors may be out of the cord (10 tumors), on the posterior roots (28 tumors), or within the cord.
(4) The method used in connection with the well known autoplastic reimplantation not only presents an alternative to the traditional apicoectomy but also provides additional stabilization of the tooth by lengthing the root with cocotostabile and biocompatible A1203 ceramic.
(5) But the roots of Ukip support in working-class areas are also cultural.
(6) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(7) I am rooting hard for you.” Ronald Reagan simply told his former vice-president Bush: “Don’t let the turkeys get you down.” By 10.30am Michelle Obama and Melania Trump will join the outgoing and incoming presidents in a presidential limousine to drive to the Capitol.
(8) Two hundred and forty root canals of extracted single-rooted teeth were prepared to the same dimension, and Dentatus posts of equal size were cemented without screwing them into the dentine.
(9) We have characterized previously a model of herpes simplex virus (HSV) infection of rat dorsal root ganglia (DRG) following cutaneous infection.
(10) After 1 month, scaling and root planing had effected significant clinical improvement and significant shifts in the subgingival flora to a pattern more consistent with periodontal health; these changes were still evident at 3 months.
(11) The dispute is rooted in the recent erosion of many of the freedoms Egyptians won when they rose up against Mubarak in a stunning, 18-day uprising.
(12) So the government wants a “root and branch” review to decide whether the BBC has “been chasing mass ratings at the expense of its original public service brief” ( BBC faces ‘root and branch’ review of its size and remit , 13 July).
(13) Statistical diagnostic tests are used for the final evaluation of the method acceptability, specifically in deciding whether or not the systematic error indicated requires a root source search for its removal or is simply a calibration constant of the method.
(14) Three strains of fluorescent pseudomonads (IS-1, IS-2, and IS-3) isolated from potato underground stems with roots showed in vitro antibiosis against 30 strains of the ring rot bacterium Clavibacter michiganensis subsp.
(15) The ventral root dissection technique was used to obtain contractile and electromyogram (e.m.g.)
(16) No infection threads were found to penetrate either root hairs or the nodule cells.
(17) The roots of the incisor teeth should, if possible, be placed accurately in this zone and a method of achieving this is suggested.
(18) Terrorist groups need to be tackled at root, interdicting flows of weapons and finance, exposing the shallowness of their claims, channelling their followers into democratic politics.
(19) Rooting latency showed a significant additive maternal strain effect but little systematic effect of pup genotype.
(20) Dorsal root ganglion (DRG) neurons cultured from neonatal rats contained high concentrations of protein kinase C (PKC).