(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Gutter
Definition:
(n.) A channel at the eaves of a roof for conveying away the rain; an eaves channel; an eaves trough.
(n.) A small channel at the roadside or elsewhere, to lead off surface water.
(n.) Any narrow channel or groove; as, a gutter formed by erosion in the vent of a gun from repeated firing.
(v. t.) To cut or form into small longitudinal hollows; to channel.
(v. t.) To supply with a gutter or gutters.
(v. i.) To become channeled, as a candle when the flame flares in the wind.
Example Sentences:
(1) This is basically a large tank (the bigger the better) that collects rain from the house guttering and pumps it into the home, to be used for flushing the loo.
(2) These lanes encourage cyclists to 'ride in the gutter' which in itself is a very dangerous riding position – especially on busy congested roads as it places the cyclist right in a motorist's blind spot.
(3) The size of presynaptic release site structures was determined by examining serial transverse sections through entire terminal branches with the transmission electron microscope; the size of postsynaptic release site structures was determined by examining terminal gutters with the scanning electron microscope after the removal of terminal branches.
(4) Yes, Goldsmith is to be held in contempt: a man of decency would have rejected this gutter strategy.
(5) More time in bed, more time with the kids, more time to read, see your mum, hang out with friends, repair the guttering, make music, fix lunch, walk in the park.
(6) Had they bothered to inquire of a veteran from the ranks, they might have heard how exasperating it is to see the dainty long-range patriots of Labour thrashing it out with the staunch gutter jingoists of the Conservative party – and barely a non-commissioned vet among them.
(7) No clear gross or histological distinctions between the ventricular "candle gutterings" and "tumors" have been identified.
(8) Most transposed ovaries were located along the paracolic gutters near the iliac crests, creating an extrinsic mass effect on adjacent bowel.
(9) Golf balls, bottles, fireworks, umbrellas and even cast iron rain gutter was thrown at republicans marching along Royal Avenue.
(10) !— she wants you to put out the bins and clear the gutters of leaves like you’ve been promising to do for six months.
(11) A one-piece integral tube and plate with a slit-valve mechanism designed to regulate post-operative intraocular pressure had a very variable response in 27 eyes, with mean pressures similar to those after unligated tube and gutters.
(12) Blood gutters brightly against his green gown, yet the man doesn't shudder or stagger or sink but trudges towards them on those tree-trunk legs and rummages around, reaches at their feet and cops hold of his head and hoists it high, and strides to his steed, snatches the bridle, steps into the stirrup and swings into the saddle still gripping his head by a handful of hair.
(13) In the second, density would decrease from the crest border, where the value was that of the gutter edge, to the fold end, where the value would be 50% lower.
(14) Following the sting, Ferguson apologised for a “serious lapse of judgment” and told the US talkshow host Oprah Winfrey she had been drinking and was “in the gutter at that moment”.
(15) The characteristics of the innervation revealed by the cholinesterase activity, concentrated in the synaptic gutters and the direct study of the nerve fibres, show focal, mono-axonal 'en plaques' endings, typical of the phasic motor system.
(16) The flame of ultra Serb nationalism appears to be guttering, although it could be replaced with a quieter long-lasting resentment.
(17) For larger exposure of the artery, the foramen transversarium of C1 must be unroofed and the artery dissected in the guttering of the posterior arch of the atlas.
(18) In a surgical technique termed ovarian transposition, the ovary is repositioned to the iliac fossa or paracolic gutter outside the radiation field.
(19) That “trollumnist” Mark Latham, that “misogynist”, “venal”, “crazy-eyed moron” whose views should be “rejected and dismantled and kicked into the gutter where they belong” has resigned from the Australian Financial Review.
(20) This comes from a man who insisted on a mass cull of badgers against scientific advice , who stripped away the last regulations protecting the soil from erosion , who believed that “ the purpose of waterways is to get rid of water ” and sought to turn our rivers into featureless gutters ,and who championed the pesticides that appear to be destroying bees and other animals .