(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Quirk
Definition:
(n.) A sudden turn; a starting from the point or line; hence, an artful evasion or subterfuge; a shift; a quibble; as, the quirks of a pettifogger.
(n.) A fit or turn; a short paroxysm; a caprice.
(n.) A smart retort; a quibble; a shallow conceit.
(n.) An irregular air; as, light quirks of music.
(n.) A piece of ground taken out of any regular ground plot or floor, so as to make a court, yard, etc.; -- sometimes written quink.
(n.) A small channel, deeply recessed in proportion to its width, used to insulate and give relief to a convex rounded molding.
Example Sentences:
(1) There is religious freedom in Britain – some would say too much: 26 bishops sit in the House of Lords on a historic quirk.
(2) A quirk of the General Chiropractic Council's rules means that chiropractors who make claims that are incompatible with previous Advertising Standards Authority rulings must be investigated by the regulator.
(3) From time to time I'd bump into Amy she had good banter so we could chat a bit and have a laugh, she was a character but that world was riddled with half-cut, doped-up chancers, I was one of them, even in early recovery I was kept afloat only by clinging to the bodies of strangers so Winehouse, but for her gentle quirks didn't especially register.
(4) The 8,000 –2,000 children and young people over the course of a year and 6,000 older and disabled adults – are users of social care services in Quirk’s borough of Lewisham.
(5) But if Microsoft can iron out some performance quirks around voice recognition and Snap, the decision won't be too hard: it's far easier to glimpse the future potential in the Xbox One, starting with 10 seconds of time and the simple two-word voice command: 'Xbox on.'"
(6) Any quirk in the way a small number of people on our schemes are counted makes little difference.
(7) It could be that grouping makes sense, especially when you think of how very specialist some services are becoming, such as commissioning for dementia care,” says Quirk.
(8) But vampires and zombies are old news, according to Quirk.
(9) Fake or misleading news spreads like wildfire on Facebook because of confirmation bias, a quirk in human psychology that makes us more likely to accept information that conforms to our existing world views.
(10) A detail-rich paint job and enough sounds and quirks are able to convince you, with a touch of the suspension of disbelief, that he is more than just an expensive chunk of plastic.
(11) All are taking on the expansive driving genre introduced by Test Drive Unlimited and reworking it for next-gen hardware, but right now it's difficult to tease out the individual quirks amid all that brushed aluminium and lasciviously winking lens flare.
(12) As she remembers her years at a kind of country boarding school called Hailsham, the quirks of her narration nudge the reader to guess at what she is not telling us.
(13) Brin, who is more sociable than Page, has his own quirks.
(14) Thanks to the labyrinthine quirks of our electoral system, none of this may get in the way of a "win" in 2015.
(15) Comedy While the French were being amused by the subtle quirks of Tati's Monsieur Hulot, the English were clutching their sides at large-breasted women losing their bikinis, and men saying "phwoooar" or "oooh" a lot.
(16) A UK remake is reportedly on the way, which in my opinion is redundant, although it does boast a fine cast including Pauline Quirke and John Challis.
(17) There was also a $5m lawsuit (from Trump, of all quirks, as opposed to the orangutan species).
(18) And this, by a happy quirk of fate, is also Emmanuelle Riva's 86th birthday.
(19) Pancreatic enzyme products are formulated, manufactured, and sold without submitting efficacy or bioavailability data to the Food and Drug Administration because of a quirk in the law.
(20) Economists often concern themselves with distortions created by quirks in the tax code or barriers to trade, but the losses from having an economy operate below full employment dwarf these inefficiencies.