(1) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(2) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(3) The commercially available chromogenic p-nitroanilide substrates Pro-Phe-Arg-NH-Np (S2302 or chromozym PK), Glp-Pro-Arg-NH-Np (S2366), Ile-Glu-(piperidyl)-Gly-Arg-NH-Np (S2337), and Ile-Glu-Gly-Arg-NH-Np (S2222) were tested for their suitability as substrates in these assays.
(4) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(5) Ile-tRNA synthetase shows little inactivation in either process.
(6) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(7) The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).
(8) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(9) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(10) The alpha His58(E7) to Gly and Val62(E11) to Ala substitutions caused 80- and 3-fold increases, respectively, in k'CO for T-state alpha subunits, and the alpha Val62(E11) to Ile mutation caused a 3-fold decrease.
(11) Resonances from several amino acids including His 16, Gly 24, Ile 48, and Met 61 experience strong ring-current shifts due to their placement near the heme.
(12) The terminal sequences are: NH2-Ile-Val-Gly-Gly-Ile-Asp.....Gly-Lys-Tyr-Pro-Tyr-Gln-Val-Ser-Leu-Arg-COOH.
(13) Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.
(14) Site-directed mutation of codon 203 and transient expression of these cDNA in COS-7 cells indicated that Phe, Ile, Leu, and Val permit transmembrane expression, whereas Ser, Thr, Tyr, Asn, Gly, Ala, Asp and Lys enable phosphatidylinositol-glycan attachment.
(15) The N-terminal amino acid sequence of this sialidase, Ala-Asp-X-Ile-Phe-Val-Arg-Glu-Thr-Arg-Ile-Pro-, was determined.
(16) Supplementation of the low protein diet with a synthetic mixture of branched-chain AA (Val, Leu and Ile) normalized the plasma levels of these AA.
(17) They correspond to the sequence from Leu-149 to Ile-162.
(18) The N5 atom of flavin interacts with the amide NH of Ile 59 in A.
(19) Chymotrypsin cleavage of this peptide resulted in a single-labeled fragment with the sequence: Glu-Val-Ala-Asn-(Pyridoxal-P-Lys)-Val-Gly-Gly-Ile-Tyr.
(20) Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production.
Lie
Definition:
(n.) See Lye.
(n.) A falsehood uttered or acted for the purpose of deception; an intentional violation of truth; an untruth spoken with the intention to deceive.
(n.) A fiction; a fable; an untruth.
(n.) Anything which misleads or disappoints.
(v. i.) To utter falsehood with an intention to deceive; to say or do that which is intended to deceive another, when he a right to know the truth, or when morality requires a just representation.
(adj.) To rest extended on the ground, a bed, or any support; to be, or to put one's self, in an horizontal position, or nearly so; to be prostate; to be stretched out; -- often with down, when predicated of living creatures; as, the book lies on the table; the snow lies on the roof; he lies in his coffin.
(adj.) To be situated; to occupy a certain place; as, Ireland lies west of England; the meadows lie along the river; the ship lay in port.
(adj.) To abide; to remain for a longer or shorter time; to be in a certain state or condition; as, to lie waste; to lie fallow; to lie open; to lie hid; to lie grieving; to lie under one's displeasure; to lie at the mercy of the waves; the paper does not lie smooth on the wall.
(adj.) To be or exist; to belong or pertain; to have an abiding place; to consist; -- with in.
(adj.) To lodge; to sleep.
(adj.) To be still or quiet, like one lying down to rest.
(adj.) To be sustainable; to be capable of being maintained.
(n.) The position or way in which anything lies; the lay, as of land or country.
Example Sentences:
(1) A diplomatic source said the killing appeared particularly unusual because of Farooq lack of recent political activity: "He was lying low in the past two years.
(2) Along the spectrum of loyalties lie multiple loyalties and ambiguous loyalties, and the latter, if unresolved, create moral ambiguities.
(3) Periosteal chondroma is an uncommon benign cartilagenous lesion, and its importance lies primarily in its characteristic radiographic and pathologic appearance which should be of assistance in the differential diagnosis of eccentric lesions of bones.
(4) 8.47pm: Cameron says he believes Britain's best days lie ahead and that he believes in public service.
(5) They are just literally lying.” In August Microsoft severed its ties, saying Alec’s stance on climate change and several other issues “conflicted directly with Microsoft’s values”.
(6) The bundles may lie parallel to the plasma membrane and to the long axis of the cell.
(7) The greatest advantages of spinal QCT for noninvasive bone mineral measurement lie in the high precision of the technique, the high sensitivity of the vertebral trabecular measurement site, and the potential for widespread application.
(8) The value of benefit-risk, benefit-cost, and cost-effectiveness analyses lies not in providing the definitive basis for a decision on vaccine use or evaluation.
(9) So I am, of course, intrigued about the city’s newest tourist attraction: a hangover bar, open at weekends, in which sufferers can come in and have a bit of a lie down in soothingly subdued lighting, while sipping vitamin-enriched smoothies.
(10) The C-terminal sequence contains an amphiphilic alpha-helix of four turns which lies on the surface of the beta-barrel.
(11) The lies Trump told this week: from murder rates to climate change Read more “President Obama has commuted the sentences of record numbers of high-level drug traffickers.
(12) Hamish Kale Floating sauna near Uppsala, Sweden Just outside Uppsala, around one hour north of Stockholm, lies the picturesque outdoor adventure area of Fjällnora.
(13) We attribute the greater strength of the step-cut repair to the additional number of epitendinous loops, which lie perpendicular to the long axis of the tendon.
(14) This contrasts sharply with the reduction in both the frequency and surface area of sensory neuron active zones that accompanies long-term habituation, and suggests that modulation of active zone number and size may be an anatomical correlate that lies in the long-term domain.
(15) Police in Rockhampton have ordered residents to leave their homes as electricity is switched off in low-lying areas.
(16) The additional value of these methods, especially of the intensive monitoring, lies also in the possibility of compiling new knowledge about semiology and electro-clinical correlation of epileptic seizures, possible trigger mechanisms and long-term therapeutic effects.
(17) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(18) Day by day we strive to unmask all the lies told to citizens.
(19) When an exercise test is not performed, a resting radionuclide left ventricular ejection fraction is recommended, and coronary angiography is considered if the value lies between 0.20 and 0.44 (12% 1-year mortality).
(20) Pre and post infusion blood samples were drawn from a catheter lying at the lower inferior vena cava and analyzed for prostaglandin E and F, and progesterone.