(1) An insulin response element (IRE) has been identified in the prolactin gene using chimeric plasmids in which prolactin promoter DNA directs expression of the bacterial chloramphenicol acetyltransferase gene.
(2) The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.
(3) Government officials drew the public’s ire after charging Manning with three counts of misconduct following the suicide attempt, including two which carried possible penalties of indefinite solitary confinement.
(4) In a prospective, blinded trial, 40 healthy adult subjects using six IRED thermometers with two techniques were examined in random sequence.
(5) On Wednesday, the ire of the marchers was focused on all those Lib Dems who blithely signed the NUS's anti-fees pledge ("I pledge to vote against any increase in fees in the next parliament and to pressure the government to introduce a fairer alternative" – yesterday, Nick Clegg limply said that he "should have been more careful" than to put his name to it).
(6) Oleg Sentsov should make new films, not count years in prison.” Facebook Twitter Pinterest Oleg Sentsov sings the Ukrainian national anthem as he is sentenced to 20 years in a Russian penal colony Sentsov attracted the ire of the Russian authorities after helping to organise a campaign protesting at Russia’s occupation and annexation of Crimea in March 2014.
(7) A deletion and reconstitution study was undertaken to address the possibility that regions of the ferritin gene and mRNA other than the IRE may be necessary for the production of the full range of iron regulation.
(8) Her predecessor, Nick Robinson, attracted similar ire by upsetting Scottish nationalists .
(9) Interestingly, the FRP which remains active at a given hemin concentration binds to the IRE with the same high affinity as untreated FRP.
(10) The results strongly suggest that HCV RNA carries an internal ribosome entry site (IRES).
(11) Among the 17 pancreatic cancer patients with elevated IRE, 10 underwent radical resection of the cancer but in none of the five patients with normal serum IRE could radical resection be carried out.
(12) In addition, a poor sequence context around AUG-11 results in increased initiation at one or more downstream AUG codons, indicative of leaky scanning or jumping by the ribosome from AUG-11 mediated by the EMCV IRES.
(13) Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase.
(14) Regulation in both instances is mediated by binding of a cytosolic protein to the IREs.
(15) Binding of the IRE-BP represses ferritin translation and represses degradation of the TfR mRNA.
(16) Yet in doing so it presents an angled mirror-polished cliff face of glass, which has been reflecting the sun straight across into the Lloyds offices across the road – the seminal "inside-out" machine that Rogers designed 30 years earlier – much to the ire of its tenants.
(17) The nations with the highest recorded levels include Colombia, Uganda, Afghanistan, India, Pakistan, Bangladesh and Nepal, with the south Asian countries in particular producing unforgettable images of disfigured women who have been assaulted with acid because they have rejected sexual advances or marriage proposals, or aroused jealousy, or in some way or other inconvenienced the patriarchy and aroused its ire.
(18) Artificial mono- and dicistronic mRNAs were prepared and used to identify the region that carried the IRES.
(19) Two melanotic human melanoma cell lines, IRE 1 and IRE 2, and the lymphoma- and leukaemia-derived cell lines Raji and K 562, were exposed to different concentrations (from 5 X 10(-3) M to 10(-5) M) of phenols, both substrates (s) and non-substrates (ns) of tyrosinase, in the presence or absence of the oxygen-radical-scavenger enzymes superoxide dismutase, catalase and peroxidase.
(20) Afterwards, she was "suddenly beautiful", and though the attention this brought was occasionally useful, mostly it was just a pain in the butt: the tiresome suggestions that she had only got on thanks to her appearance; the hurtful ire of that other great feminist, Betty Friedan, whose loathing of Steinem seemed mostly to be motivated by envy.
Irk
Definition:
(v. t.) To weary; to give pain; to annoy; -- used only impersonally at present.
Example Sentences:
(1) When the rats were grouped into animals with mild (20%), moderate (50%), and severe (80%) reductions in maximal IRK activity, it was found that the mild and moderate defects could be reversed once the receptors were subjected to extensive autophosphorylation in vitro.
(2) We characterized the mechanism of IRK inhibition and studied whether it is the consequence of a glucose-induced stimulation of protein kinase C (PKC).
(3) 18 May 2014 New £69.4bn proposal, worth £55 a share, piles pressure on AstraZeneca's board to enter negotiations with Pfizer 19 May 2014 AstraZeneca board rejects Pfizer's final £69bn takeover bid , irking some large shareholders
(4) Reports of George’s stag do at Ristorante da Ivo near St Mark’s Square with the free £3,000 meal featuring six flavours of ice cream, including takeaway cartons, initially irked me.
(5) Joleon Lescott last weekend irked supporters by clumsily saying relegation was a “weight off the shoulders”.
(6) Wenger must be the only manager in football to be irked by reports that he will be offered a new deal.
(7) Walking by last Monday, Trump gestured towards an image of his inauguration crowd – a point that still irks him – and told reporters there would soon be an official statement about the future of his national security adviser, Michael Flynn.
(8) Blogger Yomi Adegoke said: "Thinly veiling vanity as philanthropy more than irks … the pretence these images are for anything other than an onslaught of 'natural beauty' acclamations, coupled with pats on the back for 'fighting the cause' makes the no makeup selfie mania even harder to stomach."
(9) We, therefore, conclude that glucose intolerance in aging could be attributed at least in part to acquired defects in the in vivo activation of the hepatic IRK, which results in reduced phosphorylation of its putative substrate pp180.
(10) But while agreeing that the results should not be exaggerated, D'Alimonte still thinks they indicate that the Five Star shine is wearing off among some voters - including those who were irked by the rambunctious figurehead's refusal to support a minority government led by the centre-left Democratic party (PD), thus forcing the PD to form a coalition with Berlusconi's centre-right.
(11) The corporation's power online and expanding digital TV and radio channels have irked beleaguered commercial rivals, resulting in an attack by James Murdoch, head of News Corporation in the UK.
(12) The home crowd turned their ire on the Hungarian referee Viktor Kassai – his decision to dismiss Piiroja for handball in the 76th minute particularly irked them – but they were deluding themselves if they thought he was to blame.
(13) Right now is not the time.” The midfielder refused to be drawn on suggestions that his team-mates were irked by his comments, and insisted the atmosphere among the squad in Brazil was similar to during the glorious Euro 2012 campaign.
(14) Hyperglycemia causes insulin-receptor kinase (IRK) resistance in fat cells.
(15) The comments irked the geologists' professional body, which was founded in 1807 as a dining club in a London pub.
(16) Philip Hammond appears to have irked the prime minister by making a sexist remark in cabinet, exposing the tensions at the highest level of government.
(17) Look, he’s the clear frontrunner, he’s been in six debates already, answered more questions from the media than any other candidate on the stage combined.” The Fox News press release that irked Trump and led to his withdrawal read: “We learned from a secret back channel that the Ayatollah and Putin both intend to treat Donald Trump unfairly when they meet with him if he becomes president – a nefarious source tells us that Trump has his own secret plan to replace the Cabinet with his Twitter followers to see if he should even go to those meetings.” Trump derided it as “a wise guy press release .
(18) To determine whether defects in insulin receptor kinase (IRK) activity or in the phosphorylation of its physiological substrates underlie this age-related phenomenon, young (2-3 months old) and old (24-27 months old) Wistar rats were studied.
(19) Field has already irked the medallion stallion with some low blows before the bell has rung, but it looks doubtful whether punches will be pulled for the number crunchers.
(20) Linehan, who turned 44 last week, is irked by the persistence of the idea that the sitcom that brought him and Arthur Mathews to the attention of millions has canned laughter on it.