(1) An insulin response element (IRE) has been identified in the prolactin gene using chimeric plasmids in which prolactin promoter DNA directs expression of the bacterial chloramphenicol acetyltransferase gene.
(2) The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.
(3) Government officials drew the public’s ire after charging Manning with three counts of misconduct following the suicide attempt, including two which carried possible penalties of indefinite solitary confinement.
(4) In a prospective, blinded trial, 40 healthy adult subjects using six IRED thermometers with two techniques were examined in random sequence.
(5) On Wednesday, the ire of the marchers was focused on all those Lib Dems who blithely signed the NUS's anti-fees pledge ("I pledge to vote against any increase in fees in the next parliament and to pressure the government to introduce a fairer alternative" – yesterday, Nick Clegg limply said that he "should have been more careful" than to put his name to it).
(6) Oleg Sentsov should make new films, not count years in prison.” Facebook Twitter Pinterest Oleg Sentsov sings the Ukrainian national anthem as he is sentenced to 20 years in a Russian penal colony Sentsov attracted the ire of the Russian authorities after helping to organise a campaign protesting at Russia’s occupation and annexation of Crimea in March 2014.
(7) A deletion and reconstitution study was undertaken to address the possibility that regions of the ferritin gene and mRNA other than the IRE may be necessary for the production of the full range of iron regulation.
(8) Her predecessor, Nick Robinson, attracted similar ire by upsetting Scottish nationalists .
(9) Interestingly, the FRP which remains active at a given hemin concentration binds to the IRE with the same high affinity as untreated FRP.
(10) The results strongly suggest that HCV RNA carries an internal ribosome entry site (IRES).
(11) Among the 17 pancreatic cancer patients with elevated IRE, 10 underwent radical resection of the cancer but in none of the five patients with normal serum IRE could radical resection be carried out.
(12) In addition, a poor sequence context around AUG-11 results in increased initiation at one or more downstream AUG codons, indicative of leaky scanning or jumping by the ribosome from AUG-11 mediated by the EMCV IRES.
(13) Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase.
(14) Regulation in both instances is mediated by binding of a cytosolic protein to the IREs.
(15) Binding of the IRE-BP represses ferritin translation and represses degradation of the TfR mRNA.
(16) Yet in doing so it presents an angled mirror-polished cliff face of glass, which has been reflecting the sun straight across into the Lloyds offices across the road – the seminal "inside-out" machine that Rogers designed 30 years earlier – much to the ire of its tenants.
(17) The nations with the highest recorded levels include Colombia, Uganda, Afghanistan, India, Pakistan, Bangladesh and Nepal, with the south Asian countries in particular producing unforgettable images of disfigured women who have been assaulted with acid because they have rejected sexual advances or marriage proposals, or aroused jealousy, or in some way or other inconvenienced the patriarchy and aroused its ire.
(18) Artificial mono- and dicistronic mRNAs were prepared and used to identify the region that carried the IRES.
(19) Two melanotic human melanoma cell lines, IRE 1 and IRE 2, and the lymphoma- and leukaemia-derived cell lines Raji and K 562, were exposed to different concentrations (from 5 X 10(-3) M to 10(-5) M) of phenols, both substrates (s) and non-substrates (ns) of tyrosinase, in the presence or absence of the oxygen-radical-scavenger enzymes superoxide dismutase, catalase and peroxidase.
(20) Afterwards, she was "suddenly beautiful", and though the attention this brought was occasionally useful, mostly it was just a pain in the butt: the tiresome suggestions that she had only got on thanks to her appearance; the hurtful ire of that other great feminist, Betty Friedan, whose loathing of Steinem seemed mostly to be motivated by envy.
Irritate
Definition:
(v. t.) To render null and void.
(v. t.) To increase the action or violence of; to heighten excitement in; to intensify; to stimulate.
(v. t.) To excite anger or displeasure in; to provoke; to tease; to exasperate; to annoy; to vex; as, the insolence of a tyrant irritates his subjects.
(v. t.) To produce irritation in; to stimulate; to cause to contract. See Irritation, n., 2.
(n.) To make morbidly excitable, or oversensitive; to fret; as, the skin is irritated by friction; to irritate a wound by a coarse bandage.
(a.) Excited; heightened.
Example Sentences:
(1) Postpartum management is directed toward decreasing vasospasm and central nervous system irritability and maintaining fluid and electrolyte balance.
(2) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
(3) It was shown that the antibiotic had low acute toxicity, did not cumulate and had no skin-irritating effect.
(4) Inhibition of binding of [3H]TPA to the receptor preparation by tigliane and ingenane DTE correlates with irritant activity in vivo, while some daphnane and 1 alpha-alkyldaphnane DTE inhibit binding of [3H]TPA in a less pronounced manner but still are very irritant.
(5) Exposure to irritants was also more common among the asthmatics than the nonasthmatics with similar exposure to organic allergens (P = 0.004).
(6) The purpose of this study was to develop a new model for the induction of chronic irritant contact dermatitis, which would reflect well the conditions of daily practice.
(7) The drug I started taking caused an irritating, chronic cough, which disappeared when I switched to an inexpensive diuretic.
(8) These injections led to epidermal hyperplasia in areas overlying the irritant and the effect was most significant when the irritant was placed in the upper dermis.
(9) Two children required lidocaine therapy for cardiac irritability manifesting as multifocal PVCs and ventricular tachycardia.
(10) In autumn, leaf-heaps composted themselves on sunken patios, and were shovelled up by irritated owners of basement flats.
(11) The dietary fibre intake of 25 patients with the irritable bowel syndrome was assessed by dietary recall over one week for the period before onset of symptoms, at diagnosis and after six months treatment with bran and a fibre-rich diet, and compared with controls matched for age and sex.
(12) A case of epidermoid tumor of the sacral area with S3 root irritation resulting in bladder dysfunction is presented and its possible relationship to spinal puncture is discussed.
(13) The present study did not identify any baseline parameters such as initial prostate volume, peak flow rates, or obstructive or irritative symptom scores that correlated with clinical outcome.
(14) Scores on the "dependent smoking" subscale of the smoking motivation questionnaire correlated significantly with overall withdrawal severity, craving, and increased irritability.
(15) The airways can be affected by inflammation, can be targets of infection, and can respond to chemical irritants with bronchoconstrictive responses.
(16) Some pulp irritation can occur if deep restorations are not placed over a protective film.
(17) MIDAZOLAM IS SUPERIOR TO DIAZEPAM IN CERTAIN WAYS: it has a more rapid onset; produces greater anterograde amnesia, less postoperative drowsiness, less venous irritation and less likelihood of thrombophlebitis development.
(18) Primary invasive adenocarcinoma of the bladder was diagnosed in a fifty-two-year-old male with a two-month history of irritative voiding symptoms.
(19) We studied seventy patients, 23 males and 47 females with irritable bowel syndrome in adolescence aged 13-19 yrs, who visited the department of psychosomatic medicine in Takano Hospital during about six year period of April, 1986-July, 1992.
(20) The study suggested that 1) diabetes and "prediabetes" produce significant changes in levels of chondroitin 4, 6, and dermatan sulfates within alveolar bone, 2) in "prediabetic" animals, interdental bone loss occurs prior to the onset of clinical symptoms and in the absence of local irritating factors, the bone height appears to return to normal levels, and 3) there may be a correlation between alveolar bone height and relative levels of dermatan sulfate.