(1) An insulin response element (IRE) has been identified in the prolactin gene using chimeric plasmids in which prolactin promoter DNA directs expression of the bacterial chloramphenicol acetyltransferase gene.
(2) The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.
(3) Government officials drew the public’s ire after charging Manning with three counts of misconduct following the suicide attempt, including two which carried possible penalties of indefinite solitary confinement.
(4) In a prospective, blinded trial, 40 healthy adult subjects using six IRED thermometers with two techniques were examined in random sequence.
(5) On Wednesday, the ire of the marchers was focused on all those Lib Dems who blithely signed the NUS's anti-fees pledge ("I pledge to vote against any increase in fees in the next parliament and to pressure the government to introduce a fairer alternative" – yesterday, Nick Clegg limply said that he "should have been more careful" than to put his name to it).
(6) Oleg Sentsov should make new films, not count years in prison.” Facebook Twitter Pinterest Oleg Sentsov sings the Ukrainian national anthem as he is sentenced to 20 years in a Russian penal colony Sentsov attracted the ire of the Russian authorities after helping to organise a campaign protesting at Russia’s occupation and annexation of Crimea in March 2014.
(7) A deletion and reconstitution study was undertaken to address the possibility that regions of the ferritin gene and mRNA other than the IRE may be necessary for the production of the full range of iron regulation.
(8) Her predecessor, Nick Robinson, attracted similar ire by upsetting Scottish nationalists .
(9) Interestingly, the FRP which remains active at a given hemin concentration binds to the IRE with the same high affinity as untreated FRP.
(10) The results strongly suggest that HCV RNA carries an internal ribosome entry site (IRES).
(11) Among the 17 pancreatic cancer patients with elevated IRE, 10 underwent radical resection of the cancer but in none of the five patients with normal serum IRE could radical resection be carried out.
(12) In addition, a poor sequence context around AUG-11 results in increased initiation at one or more downstream AUG codons, indicative of leaky scanning or jumping by the ribosome from AUG-11 mediated by the EMCV IRES.
(13) Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase.
(14) Regulation in both instances is mediated by binding of a cytosolic protein to the IREs.
(15) Binding of the IRE-BP represses ferritin translation and represses degradation of the TfR mRNA.
(16) Yet in doing so it presents an angled mirror-polished cliff face of glass, which has been reflecting the sun straight across into the Lloyds offices across the road – the seminal "inside-out" machine that Rogers designed 30 years earlier – much to the ire of its tenants.
(17) The nations with the highest recorded levels include Colombia, Uganda, Afghanistan, India, Pakistan, Bangladesh and Nepal, with the south Asian countries in particular producing unforgettable images of disfigured women who have been assaulted with acid because they have rejected sexual advances or marriage proposals, or aroused jealousy, or in some way or other inconvenienced the patriarchy and aroused its ire.
(18) Artificial mono- and dicistronic mRNAs were prepared and used to identify the region that carried the IRES.
(19) Two melanotic human melanoma cell lines, IRE 1 and IRE 2, and the lymphoma- and leukaemia-derived cell lines Raji and K 562, were exposed to different concentrations (from 5 X 10(-3) M to 10(-5) M) of phenols, both substrates (s) and non-substrates (ns) of tyrosinase, in the presence or absence of the oxygen-radical-scavenger enzymes superoxide dismutase, catalase and peroxidase.
(20) Afterwards, she was "suddenly beautiful", and though the attention this brought was occasionally useful, mostly it was just a pain in the butt: the tiresome suggestions that she had only got on thanks to her appearance; the hurtful ire of that other great feminist, Betty Friedan, whose loathing of Steinem seemed mostly to be motivated by envy.
Tire
Definition:
(n.) A tier, row, or rank. See Tier.
(n.) Attire; apparel.
(n.) A covering for the head; a headdress.
(n.) A child's apron, covering the breast and having no sleeves; a pinafore; a tier.
(n.) Furniture; apparatus; equipment.
(n.) A hoop or band, as of metal, on the circumference of the wheel of a vehicle, to impart strength and receive the wear.
(v. t.) To adorn; to attire; to dress.
(v. i.) To seize, pull, and tear prey, as a hawk does.
(v. i.) To seize, rend, or tear something as prey; to be fixed upon, or engaged with, anything.
(v. i.) To become weary; to be fatigued; to have the strength fail; to have the patience exhausted; as, a feeble person soon tires.
(v. t.) To exhaust the strength of, as by toil or labor; to exhaust the patience of; to wear out (one's interest, attention, or the like); to weary; to fatigue; to jade.
Example Sentences:
(1) As he sits in Athens wondering when the International Monetary Fund is going to deliver another bailout, George Papandreou might be tempted to hum a few lines of Tired of Waiting for You.
(2) I was so tired I just used to fall asleep on my feet.
(3) According to articles presented by Breitbart, Clinton is tired and ailing.
(4) That may sound familiar to Tottenham fans, who grew tired with their team’s aimless, sideways passing under André Villas-Boas.
(5) I’m personally sick and tired of Pristina and Belgrade, because we’ve been victimised by high politicians.” Facebook Twitter Pinterest The bridge connecting the Albanian and Serb parts of Mitrovica.
(6) An example calculation of rolling resistance for a polyurethane tire is given in detail.
(7) The extent of inadequate rest has prompted fears that many people are too tired to do their jobs properly, with some so sleep-deprived their brains are as confused as if they had consumed too much alcohol.
(8) Do you not get tired of the mass surveillance in this country?” Finicum told reporters.
(9) We’re tired of answering these questions,” one woman said.
(10) I’m tired, man.” But he hopes that it might be done quickly.
(11) I, along with many others, am tired of this toxic propaganda.
(12) Further the diabetics claimed to be more tired and diabetic males had more sexual concerns.
(13) Apart from that, it’s becoming increasingly tiring to see people posing about how there is no point voting because it’s all rigged, the politicians are all the same and the rest.
(14) In any case, people had tired of combative rhetoric and wanted softer platitudes.
(15) There is no guarantee of surgical success with such an injury but Murray was tiring of the constant reliance on pain killers to get through tough matches.
(16) The concentrations of 1-NP and airborne particulates changed significantly in all examined areas in parallel with the rise and fall of the frequencies of studded tire use.
(17) Transposable and interspersed repetitive elements (TIREs) are ubiquitous features of both prokaryotic and eukaryotic genomes.
(18) The players come to Australia tired and exhausted already because they’ve been going since mid-November.” Another issue is the way the women treat their practice time.
(19) But when you're tired, you've played in 94 or 95 minutes, players choose power rather than technique, rather than placing it.
(20) On the return journey, the tired passengers exchange smuggling anecdotes and safety tips.