(1) The possible involvement of a melatonergic mechanism in the control of intraocular pressure (IOP) and the genesis of light-induced avian glaucoma (LIAG) was studied by measuring N-acetyltransferase (NAT) activity and melatonin levels in the iris, ciliary body and retina-choroid during the course of LIAG development, and in normal subjects by day and night.
(2) The results suggest that melatonergic mechanisms could be involved in the elevation of IOP in LIAG.
(3) As well, a prolonged "pre-glaucoma" period is available to the investigator working with LIAG, during which a pathological course is already underway in the eye, but intraocular pressure has not yet gone up.
(4) The corneas showed some characteristic LIAG effects: small anterior chamber depth and increased corneal radius of curvature (flat cornea), as compared with diurnal rc birds.
(5) When rc chicks were reared under continuous light, the environmental condition which brings on LIAG, their already enlarged eyes showed no superimposed increases in either eye weight or globe dimensions.
(6) A number of morphological and physiological findings in LIAG are reviewed, and the LIAG system is compared with several other glaucoma model systems, in dogs, rabbits and monkeys.
(7) The retinal neurotoxin kainic acid rendered chicks behaviorally blind in the eye into which it was injected intravitrially, but this failed to prevent LIAG changes in either anterior segment or growth of the globe.
(8) This further separates the LIAG effect from the phenomenon we call albino quail macrophthalmos.
(9) Preliminary trials with quisqualic acid, another retinal neurotoxin, indicate that this agent, like kainic acid, cannot prevent LIAG eye enlargement.
(10) Thus LIAG globe enlargement, and LSM axial lengthening, appear to be vision-driven, but anterior segment changes are probably separately controlled.
(11) Intraocular pressure in LIAG has been demonstrated to be responsive to several anti-glaucoma drugs, and the system could be used for further drug testing.
(12) Domestic chicks reared under continuous dim light developed the eye enlargement and suppressed corneal growth characteristic of light-induced avian glaucoma (LIAG) and dim light buphthalmos (DLB).
(13) Under LIAG conditions, increased eye weight and global enlargement did not occur, but the characteristic anterior segment changes were seen.
(14) We also explored the relationship between hereditary blindness and two environmental interventions affecting eye development, light-induced avian glaucoma (LIAG) and the axial lengthening associated with lid-suture.
(15) When the rearing conditions were diurnal (ie, not such as to induce LIAG eye enlargement), and the light of at least "normal" brightness, lid suture still caused unilateral myopia, accompanied by a pronounced bulging of the cornea.
(16) Domestic chicks (Gallus domesticus) reared under continuous light, and thus developing light-induced avian glaucoma (LIAG), were tested at 4-hourly intervals around the clock, for evidence of hormonal or other rhythms which might be related to the eye effects of LIAG.
(17) We compared albino (aI), dilute (aID), and wild-type (AI+) quail in their ocular responses to continuous light, the rearing condition that brings on light-induced avian glaucoma (LIAG) in domestic chickens.
(18) No statistical differences in choline acetyltransferase activity, adrenergic transmitter levels or dopamine concentrations could be found in tissues of LIAG eyes vs control eyes, indicating that cholinergic, adrenergic and dopaminergic mechanisms are probably not involved in LIAG.
(19) This light-induced avian glaucoma (LIAG) is presented as an animal model system for human open-angle glaucoma.
(20) Two antiglaucoma drugs were tested on Hubbard chicks with light-induced avian glaucoma (LIAG).
Lige
Definition:
(v. t. & i.) To lie; to tell lies.
Example Sentences:
(1) Here, we report the isolation and characterization of the beta-etherase gene, which contains an open reading frame of 843 bp and which we call ligE.
(2) Inherited as an autosomal recessive trait the syndrome is characterized by a medium degree generalized osteosclerosis, open craniial sutures and fontanels until adult lige, hypoplastic mandibles with deficiency of the angle, prominence of the forehead and occiput, hypoplasia of the paranasal sinuses, commonly observed dysproportionate dwarfism, acro-osteolysis and increased bone fragility.
(3) The long tissue half-lige of actinomycin D suggeststhat an intermittenr schedule of administration would be the most effective.
(4) In another reported incident, two men shoved an 18-year-old woman wearing a hooded sweatshirt, commented on religion and asked her: “Do you know you’re in America?” In the traditionally liberal city of Ann Arbor, two alleged incidents of ethnic intimidation and religious bias in a week is unusual, said Detective Lt Matthew Lige of the Ann Arbor police department.