(n.) Descent in a line from a common progenitor; progeny; race; descending line of offspring or ascending line of parentage.
Example Sentences:
(1) Our Ph1-positive ALL revealed B-cell lineage leukemia, since their surface phenotype were Ia+ and CD10+ and they have rearranged immunoglobulin JH genes.
(2) The lineage and clonality of Hodgkin's disease (HD) were investigated by analyzing the organization of the immunoglobulin and T-cell receptor beta-chain (T beta) gene loci in 18 cases of HD, and for comparison, in a panel of 103 cases of B- and T-cell non-Hodgkin's lymphomas (NHLs) and lymphoid leukemias (LLs).
(3) The presence of a previously unreported dipeptide transport mechanism within blood leukocytes and the selective enrichment of the granule enzyme, DPPI, within cytotoxic effector cells of lymphoid or myeloid lineage appear to afford a unique mechanism for the targeting of immunotherapeutic reagents composed of simple dipeptide esters or amides.
(4) We have investigated the temporal pattern of appearance, cell lineage, and cytodifferentiation of selected sensory organs (sensilla) of adult Drosophila.
(5) After induction the aIL2r positive and negative cell subpopulations were sorted and analyzed separately for morphology, lineage specific cell surface markers, and clonogenic cell numbers.
(6) Our results suggest that cAMP may be an important regulator of phenotypic expression in at least some neural crest cell lineages.
(7) They further show that dominant, trans-acting factors present in more mature B-lineage cell lines act to down-regulate the transcription of N-myc.
(8) To identify cells of different myogenic lineages, myotubes were analyzed for content of fast and slow classes of myosin heavy chain (MHC) isoforms by immunocytochemistry and immunoblotting using specific monoclonal antibodies.
(9) Other non lineage specific markers, such as CD9 and CD38 did not seem to influence survival.
(10) TdT determination indicate would the presence of immature cells that are not detected in the normal lymphnode; molecular analysis of the rearrangements of these genes would reveal the presence of even a small monoclonal population of both T and B lineages in the lymphnodes.
(11) An analysis of 54 protein sequences from humans and rodents (mice or rats), with the chicken as an outgroup, indicates that, from the common ancestor of primates and rodents, 35 of the proteins have evolved faster in the lineage to mouse or rat (rodent lineage) whereas only 12 proteins have evolved faster in the lineage to humans (human lineage).
(12) This, of course, is not the case as determinants recognized by one monoclonal antibody may be expressed on cells of different lineage.
(13) Presented data ranged from investigations of oncogene expression in cell lines, where transcripts of unique size were identified and lineage related expressions of transcription factors described to detailed cytogenetic investigations of fresh Hodgkin's biopsy tissue.
(14) They seem likely to be useful in identifying functionally related subpopulations of neurons and describing neural cell lineages.
(15) Lymphoid tumors of a given lineage exhibit a spectrum of phenotypes from clones whose features overlap extensively with their normal counterparts to clones whose features are not obviously represented in normal lymphoid populations.
(16) LIF inhibits differentiation under several conditions which lead to endodermal and mesodermal cell lineages including skeletal and cardiac muscle.
(17) Only tumors of astrocytic lineage like astrocytomas and glioblastomas, or tumors of mixed lineage as oligo-astrocytomas and multipotential primitive neuroectodermal tumors (PNET) expressed TNF-alpha-like immunoreactivity.
(18) These data provide evidence at the clonal level for the presence of precursors of the TCR alpha beta and TCR gamma delta lineages in the human TN thymocyte pool.
(19) Ep primarily acts on the marrow to stimulate the growth and maturation of early cells in the erythroid lineage that are known as the burst-forming unit-erythroid (BFU-E) and colony-forming unit-erythroid (CFU-E).
(20) One method is to use acutely transforming retroviruses, which can transform B-lineage lymphocytes in vitro.
Progeny
Definition:
(n.) Descendants of the human kind, or offspring of other animals; children; offspring; race, lineage.
Example Sentences:
(1) The haplotype of the recombinant X chromosome of each of 241 backcross progeny has been established using the X-linked anchor loci Otc, Hprt, Dmd, Pgk-1, and Amg and the additional probes DXSmh43 and Cbx-rs1.
(2) (E)-5-(2-Bromovinyl)uridine (BVUrd), the riboside counterpart of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdUrd), effected a dose-dependent inhibition of viral progeny formation and viral DNA synthesis in herpes simplex virus type 1 (HSV-1, strain KOS)-infected human (E6SM) diploid fibroblast cells.
(3) In a second phase of the study, a comparison was made between mortality rates of male and female progeny of White Leghorn-Rhode Island Red reciprocal crosses.
(4) In the progeny of the surviving males, neither translocations nor independent fragments are found; indirect evidence indicated the occasional presence of inversions.
(5) After irradiation by 137Cs gamma-rays at a dose of 5 Gy the males were mated to unirradiated females and genetic analysis of fertility in the F1 progeny was carried out.
(6) Thus, the progeny of infected primitive multipotential cells are competent to express integrated proviruses.
(7) The finding of idiotype diversity in the PC response, as well as diversity of expression in terms of quantity and immunoglobulin class of antibody synthesized by the clonal progeny of B cells within the TEPC 15 clonotype, emphasize the heterogeneity of the B-cell population both in terms of specificity repertoire and the physiological state of cells even within a single clonotype.
(8) This unusual pattern of unbalanced growth may represent an adaptation by bdellovibrios to maximize their progeny yield from the determinate amount of substrate available within a given prey cell.
(9) A significant increase of tumour frequency was detected in the progeny of these rats.
(10) It was found that the frequency of microphthalmia and anophthalmia in the female progeny of mice fed Mouse Chow was 7.4-9.2% in B10.A and B10.BR, 4.0-5.5% in B10.A(18R), B10, B10.A(5R), B10.A(1R), B10.A(15R), and B10.A(2R), and 0.8% and 1.4% in B10.D2 and B10.OL mice, respectively.
(11) The specific cellular defects in patched mutants suggests that this gene specifies a subset of neuroblasts and neural progeny underlying the region of epidermal pattern defect.
(12) Tibial breaking strength and tibial percentage ash of the progeny at hatching was markedly improved in proportion to maternal phosphorus and food intake.
(13) The progeny exposed to DES prenatally and DMBA postnatally (DES-DMBA-exposed progeny) developed a greater multiplicity of tumors per tumor-bearing animal (p less than 0.001) and higher rates of neoplasms of the reproductive tract, e.g., ovarian and uterine tumors, mammary gland and forestomach tumors, and dermal melanomas.
(14) 6 pregnancies were carried to term, and all progeny were normal, based on physical examination at birth or 3 months after.
(15) The SF were derived from normal appearing subepidermoid biopsies of ACR individuals, their progeny and ocntrols.
(16) Defective H genomes were present in the progeny virus two passages after transfection.
(17) A germ line mutation causing a tumour ('tumour mutation') is weakly carcinogenic by itself, but it is strongly expressed in the progeny after postnatal treatment with a small dose of the carcinogenesis promoting agent urethane.
(18) In the case of LTC-IC, the production of different types of lineage-restricted and multipotent progeny was also analyzed.
(19) Sequence analysis of progeny of untreated plasmids containing putative point mutations showed insertions and deletions of bases and a broad spectrum of base substitutions; in those from BPDE-treated plasmids, all base substitutions involved guanosine .
(20) Using this assay the kinetics of appearance of the progeny of transfused bone marrow and spleen cells in the thymus of irradiated (760 R) mice has been studied.