(n.) Oneness of origin; esp. (Biol.), development of all beings in the universe from a single cell; -- opposed to polygenesis. Called also monism.
(n.) That form of reproduction which requires but one parent, as in reproduction by fission or in the formation of buds, etc., which drop off and form new individuals; asexual reproduction.
(n.) The direct development of an embryo, without metamorphosis, into an organism similar to the parent organism; -- opposed to metagenesis.
Example Sentences:
Monogenic
Definition:
(a.) Of or pertaining to monogenesis.
(a.) Producing only one kind of germs, or young; developing only in one way.
Example Sentences:
(1) Pairwise correlation between an affected parent and child is zero: The disease is monogenic (no major expression gene).
(2) The contribution of genes to the etiology of coronary heart disease (CHD) is highly significant even when monogenic hyperlipidemias are excluded.
(3) 10.6% of the children were found to have chromosomal abnormality, 26.5%--multifactorial pathology and 62.9% of children were affected by monogenic diseases.
(4) This article describes computer-based information-and-diagnostic system dealing with child hereditary diseases which makes in possible to organize automated consultative service on a wide range of monogene and chromosome syndromes.
(5) Here, it is shown that genetic variation in such 'molecular groupings' has clinical relevance, for example (1) in reproductive counselling for thalassaemia; (2) in heterozygosity where the affected enzymes are normally homopolymeric; (3) in clinical severity of 'monogenic' disease (e.g.
(6) No selective segregation was found and therefore there was no evidence suggesting linkage or supporting a monogenic theory of transmission of susceptibility to schizophrenia.
(7) Conditions such as these may be exclusively monogenic, polygenic or environmental, but in most cases both genetic and environmental factors are involved.
(8) These data show that both the null and the normal genotypes have similar amounts of the enzyme protein, but the enzyme occurs mostly as insoluble or poorly soluble polymers in nulls, and the monogenic inheritance reported for the null alleles of the glu locus is likely to be for a factor encoded by another locus which affects directly or indirectly the solubility of the enzyme by increasing its polymerization into large quaternary structures.
(9) To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families.
(10) The molecular basis of this monogenic disease is the defective functioning of the cellular receptor for LDL that recognizes apo B. Lipoprotein(a) [Lp(a)] is a circulating lipoprotein that is structurally related to LDL, as it also contains apo B.
(11) These results indicate that timolol metabolism is partly under monogenic control of the debrisoquine-type.
(12) Six patients (four women and two men) with mild to moderate hypercholesterolemia, but with no clinical evidence of the disease being monogenic familial hypercholesterolaemia and who, over the previous 3 months on a rigidly controlled hypolipidaemic diet therapy, showed no reduction in plasma cholesterol levels, were recruited into a study to assess the metabolic effects of Pirozadil, a new nicotinic acid derivative.
(13) The method, which allows the determination of the mutations in both parental and fetal DNA on the same day, should have wide application to the carrier detection and prenatal diagnosis of monogenic diseases with heterogeneous molecular defects.
(14) The transport system is under monogenic control and is inducible.
(15) Parent-offspring occurrence of an accessory triradius and absence of the c triradius suggested monogenic control.
(16) In humans, the level of TPMT activity is inherited in a monogenic fashion.
(17) The recent techniques of polymerase chain reaction may allow DNA analyses in some cases: sexing or diagnosis of monogenic diseases.
(18) The possibility of pleiotropic monogenic control of the hereditary polyposis and primary colon cancer is checked up and confirmed.
(19) cdc16-116 is a monogenic recessive mutation unlinked to any previously known cdc gene of S. pombe.
(20) These advances will have an impact on fetal diagnosis of monogenic disorders for a number of reasons, the most important being the ability to use chorionic villus DNA taken in the first trimester to make a fetal diagnosis, no matter how tissue-specific the gene defect.