(a.) Having the highest rank or jurisdiction; superior to all others; chief; supreme; preeminent; as, a paramount duty.
(n.) The highest or chief.
Example Sentences:
(1) The results of our phenotypic and functional testing of unmodified GIC (no enzyme treatment, no additional culture with or without interleukin 2), show that T cells, especially OKT8+ cells, are of paramount importance in the mechanism of this type of acute irreversible rejection of human renal allografts (i.e., to the point of allograft rupture), but other potential effector mechanisms are also present in situ.
(2) mechanisms of quality control, including extensive programs of orientation, inservice, and utilization review, are paramount in achievement of success.
(3) In the Labour party over the past two decades, the leader has become paramount, directing not just his own staff, but Labour headquarters.
(4) Urinalysis, a simple front-line test, is of paramount importance in the evaluation and management of the patient with urinary tract infection.
(5) Since the primary diagnosis of this condition is almost invariably based on cytologic observations, the diagnostic criteria are of paramount importance.
(6) José Manuel Barroso, the re-elected commission chief, stressed that rather than being seen as president of Europe, or Europe's paramount leader, the new post should be confined to the European council, which groups national governments from the member states.
(7) They emphasize that life-time diagnosis of pericardial mesothelioma is of paramount importance because rational chemotherapy permits prolongation of the patient's survival.
(8) The paramount feature revealed by immunohistological double marker analyses was the intimate association of myoid cells (antigen producing) with interdigitating reticulum cells (potentially antigen presenting cells), both of which were surrounded by T3+ lymphocytes in thymus medulla.
(9) The latter method is suitable for routine use in renography when accuracy is not of paramount importance.
(10) These preliminary data confirm the paramount importance of cellular immunity in controlling neoplasias.
(11) The use of zinc nitrate is favored if toxicological considerations are paramount, but ninhydrin development has to be carefully controlled if optimal results are to be obtained.
(12) The functional end result is of paramount importance.
(13) The symptoms of anaemia and indigestion appear to be paramount in making an early diagnosis, and negative barium meal studies should not be accepted when these two symptoms are present.
(14) These results might be of paramount significance in developing the detection method for HCV infection and in preparing HCV vaccine.
(15) Correct diagnosis and understanding of its pathogenesis is paramount in order to apply definite surgical treatment.
(16) Regardless of the technique utilized it remains paramount that the surgeon plan the initial procedure with great care as each failure results in diminished blood supply to the graft bed and makes subsequent procedures less likely to succeed.
(17) The work presented here gives a description, analysis and discussion of the effect of organic loading which is a paramount parameter of the performance of RBC's.
(18) The intended application is to assist in treatment selection during phase II trials, especially with rapid responses and when the disease involved is serious enough that design-motivating ethical considerations become paramount.
(19) Although the precise mechanism of thrombosis is incompletely known, the recognition of this type of dementia is of paramount importance as it is a potentially treatable condition.
(20) An understanding of the pathophysiology of anaphylaxis, the most serious of the allergic disorders, is paramount for its diagnosis.
Primary
Definition:
(a.) First in order of time or development or in intention; primitive; fundamental; original.
(a.) First in order, as being preparatory to something higher; as, primary assemblies; primary schools.
(a.) First in dignity or importance; chief; principal; as, primary planets; a matter of primary importance.
(a.) Earliest formed; fundamental.
(a.) Illustrating, possessing, or characterized by, some quality or property in the first degree; having undergone the first stage of substitution or replacement.
(n.) That which stands first in order, rank, or importance; a chief matter.
(n.) A primary meeting; a caucus.
(n.) One of the large feathers on the distal joint of a bird's wing. See Plumage, and Illust. of Bird.
(n.) A primary planet; the brighter component of a double star. See under Planet.
Example Sentences:
(1) The only other evidence of Kopachi's existence is the primary school near the memorial.
(2) We also show that proliferation of primary amnion cells is not dependent on a high c-fos expression, suggesting that the function of c-fos is more likely to be associated with other cellular functions in the differentiated amnion cell.
(3) A total of 555 caries lesions were registered on proximal surfaces, 49.1% being primary lesions in the enamel, 21.4% primary lesions into the dentin and 29.5% secondary lesions.
(4) Two cases with primary Carcinoma in situ (Cis) were treated with the same protocol.
(5) Taken together these results are consistent with the view that primary CTL, as well as long term cloned CTL cell lines, exercise their cytolytic activity by means of perforin.
(6) Community involvement is a key element of the Primary Health Care (PHC) approach, and thus an essential topic on a course for managers of Primary Health Care programmes.
(7) These findings raise questions regarding the efficacy of medical school curriculum in motivating career choices in primary care.
(8) In view of reports of the reduction of telomeric repeats in human malignant tumors, we measured the lengths of telomeric repeats in 55 primary neuroblastomas.
(9) The blockade of H2 receptors is the primary action of these drugs; however, they possess also secondary actions which may represent untoward effects but in some cases may be actually useful (increase in prostaglandin synthesis, inhibition of LTB4 synthesis, etc.)
(10) For related pairs, both the primes (first pictures) and targets (second pictures) varied in rated "typicality" (Rosch, 1975), being either typical or relatively atypical members of their primary superordinate category.
(11) Determination of the primary structure for factor V has provided the basis for examination of structure-function relationships.
(12) The 36-year-old teacher at an inner-city London primary school earns £40,000 a year and contributes £216 a month to her pension.
(13) If there is a will to use primary Care centres for effective preventive action in the population as a whole, motivation of the professionals involved and organisational changes will be necessary so as not to perpetuate the law of inverse care.
(14) The move would require some secondary legislation; higher fines for employers paying less than the minimum wage would require new primary legislation.
(15) Valvular stenoses of the bronchi and especially of the bronchioles in various types of primary pulmonary disease are of considerable importance etiologically.
(16) For the case described by the author primary tearing of the chiasma due to sudden applanation of the skull in the frontal region with burstfractures in the anterior cranial fossa is assumed.
(17) Of the 622 people interviewed, a large proportion (30.5%) believed that the first deciduous tooth should erupt between the age of 5-7 months; the next commonly mentioned time of tooth eruption was 7-9 months of age; and 50.3% of the respondents claimed to have seen a case of prematurely erupted primary teeth.
(18) In the triploids, the 40 female chromosomes present (mouse, n = 20) were derived from a single diploid pronucleus formed after the extrusion of a first polar body, and following the monospermic fertilization of primary oocytes.
(19) Subthreshold concentrations of the drug to induce complete blockade (5 x 10(-8)M) allowed to observe a greater depression of bioelectric cell characteristics in primary than in transitional fibres.
(20) Therefore, the measurement of the alpha-antitrypsin content plays the crucial part in differential diagnosis of primary (hereditary determined) and secondary (obstructive) emphysema.