(1) The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
(2) In senescent rats, however, the proportions of salt-soluble and detergent-soluble AChE may differ from those in young rats.
(3) In addition, we have shown that long-lived, presumably non-senescent, strains do not arise by suppressor mutation, but lose senescence plasmid DNA by another mechanism.
(4) Senescent (26-28 months) Fischer 344 rats were shown to have a lower density of D2 sites (-36%) without any change in affinity in membranes prepared from homogenized caudate-putamen (CPU), as compared to young adult (5-6 months) rats.
(5) The cell cycle-dependent changes in the transglutaminase mRNA levels strongly support the implicated involvement of the enzyme in cell growth, differentiation, and senescence.
(6) The increased levels of HK1 could affect other erythrocyte metabolic pathways slowing down the physiological rate of cellular senescence and result in increased activity levels of other cell-age-dependent enzymes.
(7) Advancing age was associated with a reduction in cell proliferative responses to PHA in both substrains, although the rate of decline was significantly more rapid in the senescence-prone animals.
(8) Instead of degenerative changes, these results show an activation of the vasopressinergic system in senescence and in SDAT patients, similar to earlier observations in the aged rat and in accordance with a rise in human neurophysin and VP levels reported recently.
(9) Thus, constitutive expression of specific cytochrome P450 genes is repressed or activated in senescent rats.
(10) Mild daily exercise, maintained throughout adult life into early senescence, attenuates muscle atrophy and promotes adaptive enzymatic changes in atrophying muscles.
(11) A second set of experiments which involved the injection of E2 into senescent male as well as female rats indicated that there were no sex differences in improvements in inclined screen performance, and that once the E2 injections were discontinued, performance returned to preadministration levels.
(12) Additionally, analysis of the multiple steps occurring in the El cultures, as well as in the emergence of the continuous cell lines, could potentially elucidate the processes occurring during human epithelial cell carcinogenesis and escape from senescence.
(13) Significant anamnestic SIgA responses were shown after oral immunization with DNP-BGG in adult rats, but was not observed in the senescent and midlife (10-12 months) rats.
(14) Modulation of cellular senescence by growth factors, hormones, and genetic manipulation is contrasted, but newer studies in oncogene involvement are omitted.
(15) Under the same conditions, PM from senescent mice generated 62% of the initial O2- produced in response to zymosan, and 45% in response to OZ.
(16) Untreated cells, or cells treated with MCA or TPA only, usually became senescent around 6-8 weeks after plating and died, but those treated with both MCA and TPA became immortalised and underwent transformation to a phenotype capable of growth in soft agar.
(17) Because immune senescence most profoundly affects T lymphocyte functions, we suspected that LIA production would decline with age.
(18) Abnormal granular structures, which stained positively with periodic acid-Schiff (PAS-positive granular structures; PGS), were observed in the brain of senescence accelerated mouse (SAM).
(19) In senescent females the number of small IMPs was decreased in the perikarya and dendritic shafts compared to young females while the number of large particles was increased in the outer leaflet of the membrane of dendritic shafts, reaching values similar to those observed in males.
(20) Our data suggest that the release of u-PA antigen by human macrovascular endothelial cells can be used as an indicator of cell senescence.
State
Definition:
(n.) The circumstances or condition of a being or thing at any given time.
(n.) Rank; condition; quality; as, the state of honor.
(n.) Condition of prosperity or grandeur; wealthy or prosperous circumstances; social importance.
(n.) Appearance of grandeur or dignity; pomp.
(n.) A chair with a canopy above it, often standing on a dais; a seat of dignity; also, the canopy itself.
(n.) Estate, possession.
(n.) A person of high rank.
(n.) Any body of men united by profession, or constituting a community of a particular character; as, the civil and ecclesiastical states, or the lords spiritual and temporal and the commons, in Great Britain. Cf. Estate, n., 6.
(n.) The principal persons in a government.
(n.) The bodies that constitute the legislature of a country; as, the States-general of Holland.
(n.) A form of government which is not monarchial, as a republic.
(n.) A political body, or body politic; the whole body of people who are united one government, whatever may be the form of the government; a nation.
(n.) In the United States, one of the commonwealth, or bodies politic, the people of which make up the body of the nation, and which, under the national constitution, stands in certain specified relations with the national government, and are invested, as commonwealth, with full power in their several spheres over all matters not expressly inhibited.
(n.) Highest and stationary condition, as that of maturity between growth and decline, or as that of crisis between the increase and the abating of a disease; height; acme.
(a.) Stately.
(a.) Belonging to the state, or body politic; public.
(v. t.) To set; to settle; to establish.
(v. t.) To express the particulars of; to set down in detail or in gross; to represent fully in words; to narrate; to recite; as, to state the facts of a case, one's opinion, etc.
(n.) A statement; also, a document containing a statement.
Example Sentences:
(1) All rats were examined in the conscious, unrestrained state 12 wk after induction of diabetes or acidified saline (pH 4.5) injection.
(2) One hundred and twenty-seven states have said with common voice that their security is directly threatened by the 15,000 nuclear weapons that exist in the arsenals of nine countries, and they are demanding that these weapons be prohibited and abolished.
(3) There was appreciable variation in toothbrush wear among subjects, some reducing their brush to a poor state in 2 weeks whereas with others the brush was rated as "good" after 10 weeks.
(4) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(5) Steady-state values of cell, glucose, and cellulase concentration oxygen tension, and outlet gas oxygen partial pressure were recorded.
(6) In cardiac tissue the adenylate system is not a good indicator of the energy state of the mitochondrion, even when the concentrations of AMP and free cytosolic ADP are calculated from the adenylate kinase and creatine kinase equilibria.
(7) M NET is currently installed in referring physician office sites across the state, with additional physician sites identified and program enhancements under development.
(8) Furthermore, their distribution in various ethnic groups residing in different districts of Rajasthan state (Western-India) is also reviewed.
(9) The results also suggest that the dispersed condition of pigment in the melanophores represents the "resting state" of the melanophores when they are under no stimulation.
(10) However, the firing of 5-HT neurons appears to relate to the state of vigilance of the animal.
(11) The Department of Herd Health and Ambulatory Clinic of the Veterinary Faculty (State University of Utrecht, The Netherlands) has developed the VAMPP package for swine breeding farms.
(12) Effects of habitual variations in napping on psychomotor performance, short-term memory and subjective states were investigated.
(13) And this is the supply of 30% of the state’s fresh water.” To conduct the survey, the state’s water agency dispatches researchers to measure the level of snow manually at 250 separate sites in the Sierra Nevada, Rizzardo said.
(14) Before issuing the ruling, the judge Shaban El-Shamy read a lengthy series of remarks detailing what he described as a litany of ills committed by the Muslim Brotherhood, including “spreading chaos and seeking to bring down the Egyptian state”.
(15) Family therapists have attempted to convert the acting-out behavioral disorders into an effective state, i.e., make the family aware of their feelings of deprivation by focusing on the aggressive component.
(16) In this phase the educational practices are vastly determined by individual activities which form the basis for later regulations by the state.
(17) Given Australia’s number one position as the worst carbon emitter per capita among major western nations it seems hardly surprising that islanders from Fiji, Samoa, Vanuatu and other small island developing states have been turning to Australia with growing exasperation demanding the country demonstrate an appropriate response and responsibility.
(18) In these liposomes, the amounts and molecular states of SL-MDP were determined from ESR spectra and are discussed in connection with its immunopotentiating property.
(19) Antral G cells increase in states of achlorhydria in man and animals provided atrophic antral gastritis is absent.
(20) Writing in the Observer , Schmidt said his company's accounts were complicated but complied with international taxation treaties that allowed it to pay most of its tax in the United States.