What's the difference between dose and response?

Dose


Definition:

  • (n.) The quantity of medicine given, or prescribed to be taken, at one time.
  • (n.) A sufficient quantity; a portion; as much as one can take, or as falls to one to receive.
  • (n.) Anything nauseous that one is obliged to take; a disagreeable portion thrust upon one.
  • (n.) To proportion properly (a medicine), with reference to the patient or the disease; to form into suitable doses.
  • (n.) To give doses to; to medicine or physic to; to give potions to, constantly and without need.
  • (n.) To give anything nauseous to.

Example Sentences:

  • (1) This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline.
  • (2) The resulting dose distribution is displayed using traditional 2-dimensional displays or as an isodose surface composited with underlying anatomy and the target volume.
  • (3) Age difference did not affect the mean dose-effect response.
  • (4) The rash presented either as a pityriasis rosea-like picture which appeared about three to six months after the onset of treatment in patients taking low doses, or alternatively, as lichenoid plaques which appeared three to six months after commencement of medication in patients taking high doses.
  • (5) Neutrons induced a dose-dependent cytotoxicity and mutation frequency in the AL cells.
  • (6) Urinary ANF immunoreactivity was significantly enhanced by candoxatril in both groups (P less than 0.05 and P less than 0.01 in groups 1 and 2, respectively), with a more pronounced effect evident at the higher dose (P less than 0.01).
  • (7) Open field behaviors and isolation-induced aggression were reduced by anxiolytics, at doses which may be within the sedative-hypnotic range.
  • (8) The fraction of the viral dose which became cell associated was independent of the incubation temperature and increased with increasing target membrane concentration.
  • (9) The second group only with Haloperidol (same dose).
  • (10) The level of gadd45 mRNA increased rapidly after X rays at doses as low as 2 Gy.
  • (11) The cumulative incidence of grade II and III acute GVHD in the 'low dose' cyclosporin group was 42% compared to 51% in the 'standard dose' group (P = 0.60).
  • (12) The diffusion of Myocamicin in the prostatic tissue of patients undergoing prostatectomy after a single oral dose of 600 mg has been studied.
  • (13) In X-irradiated litters, almost invariably, the incidence of anophthalmia was higher in exencephalic than in nonexencephalic embryos and the ratio of these incidences (relative risk) decreased toward 1 with increasing dose.
  • (14) Similarly, doses of deferoxamine at the time of the study were not different.
  • (15) A survey carried out two and three years after the launch of the official campaign also showed a reduction in the prevalence of rickets in children taking low dose supplements equivalent to about 2.5 micrograms (100 IU) vitamin D daily.
  • (16) A quantitative comparison of tissue distribution and excretion of an orally administered sublethal dose of [3H]diacetoxyscirpenol (anguidine) was made in rats and mice 90 min, 24 hr, and 7 days after treatment.
  • (17) The inhibitory effects were stronger in A549 lung cancer cells than in HEL cells at the same TFP dose.
  • (18) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
  • (19) Pituitary weight, mitotic index and chromosomes were studied in male rats following a single or repeated dose of estradiol-benzoate for a total period of 210 days.
  • (20) Estimates of the risk probability for each dose level and sacrifice time are found utilizing the sample likelihood as the posterior density.

Response


Definition:

  • (n.) The act of responding.
  • (n.) An answer or reply.
  • (n.) Reply to an objection in formal disputation.
  • (n.) The answer of the people or congregation to the priest or clergyman, in the litany and other parts of divine service.
  • (n.) A kind of anthem sung after the lessons of matins and some other parts of the office.
  • (n.) A repetition of the given subject in a fugue by another part on the fifth above or fourth below.

Example Sentences:

  • (1) Intestinal dilatation seemed in all cases a response to elevated CO2 only.
  • (2) Direct fetal digitalization led to a reduction in umbilical artery resistance, a decline in the abdominal circumference from 20.3 to 17.8 cm, and resolution of the ascites within 72 h. Despite this dramatic response to therapy, fetal death occurred on day 5 of treatment.
  • (3) Furthermore, it had early diagnostic (seven days) as well as prognostic value, as revealed by response to therapy and decrease in COA titer.
  • (4) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
  • (5) Age difference did not affect the mean dose-effect response.
  • (6) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
  • (7) Oxyhaemoglobin (4 microns at 0.35 ml.min-1) infused into the tracheal circulation almost abolished the responses to bradykinin and methacholine.
  • (8) Three categories of UV response have been identified.
  • (9) LHRH therapy leads to higher plasma LH levels and a lower FSH in response to an intravenous LHRH test.
  • (10) Bronchial challenge caused an immediate asthmatic response.
  • (11) Clinical signs of disease developed as early as 15 days after transition to the experimental diets and included impaired vision, decreased response to external stimuli, and abnormal gait.
  • (12) The telencephalic proliferative response has been studied in adult newts after lesion on the central nervous system.
  • (13) The combined immediate and delayed responses to fleas in the dog are as observed by other investigators in man and guinea pigs.
  • (14) In addition, this pretreatment protocol did not modify the recipient immune response against B-lymphocyte alloantigens which developed in unsuccessful transplants.
  • (15) In dogs, cibenzoline given i.v., had no effects on the slow response systems, probably because of sympathetic nervous system intervention since the class 4 effects of cibenzoline appeared after beta-adrenoceptor blockade.
  • (16) As a consequence, similar response curves were obtained for urine specimens containing morphine or barbiturates.
  • (17) At the early phase of the sensitization a T-cell response was seen in vitro, characterized by an increased spleen but no peripheral blood lymphocyte reactivity to T-cell mitogens at the same time as increased reactivity to the sensitizing antigen was detected.
  • (18) The ability of azelastine to influence antigen-induced contractile responses (Schultz-Dale phenomenon) in isolated tracheal segments of the guinea-pig was investigated and compared with selected antiallergic drugs and inhibitors of arachidonic acid metabolism.
  • (19) With aging, the blood vessel wall becomes hyperreactive--presumably because of an augmented vasoconstrictor and a reduced vasodilator responsiveness.
  • (20) Treatment termination due to lack of efficacy or combined insufficient therapeutic response and toxicity proved to be influenced by the initial disease activity and by the rank order of prescription.