(n.) Freedom from that which pains, or harasses, as toil, care, grief, etc.
(n.) The quality or condition of being indolent; inaction, or want of exertion of body or mind, proceeding from love of ease or aversion to toil; habitual idleness; indisposition to labor; laziness; sloth; inactivity.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Sloth
Definition:
(n.) Slowness; tardiness.
(n.) Disinclination to action or labor; sluggishness; laziness; idleness.
(n.) Any one of several species of arboreal edentates constituting the family Bradypodidae, and the suborder Tardigrada. They have long exserted limbs and long prehensile claws. Both jaws are furnished with teeth (see Illust. of Edentata), and the ears and tail are rudimentary. They inhabit South and Central America and Mexico.
(v. i.) To be idle.
Example Sentences:
(1) Although the retinal organization differs from that of the closely related three-toed sloth, the presumed function of retinal specializations in both species is to guide limb movements by permitting visualization of the branch along which the animal is climbing.
(2) Whenever anyone ascribes some inherent characteristic – of sloth or unwillingness – to an entire race, even if it is your own, you should smell a rat.
(3) The low functional residual capacity lung density in the sloth was attributable to unusually large alveoli.
(4) Over the course of this series, themes of unemployment, poor grooming and sloth emerge, all of which are qualities found in our first loser, Kris.
(5) Nick Offerman, the comic he-man of Parks and Recreation, stars as Ignatius J Reilly, a gluttonous and concupiscent layabout, slothfully adrift in New Orleans.
(6) Sloths are very responsive to epinephrine and norepinephrine; i.v.
(7) Updated at 9.20pm BST 9.01pm BST A second Republican Senate candidate has distanced himself from Mitt Romney 's discourse on the miserable sloth and entitled arrogance of 47% of Americans: Sen. Scott Brown, facing a tough fight in left-leaning Massachusetts, emails The Hill to say Romney's Randian world view of producers-versus-parasites is not his: That’s not the way I view the world.
(8) The working class is redivided into the hard-working taxpayer and the slothful undeserving poor, with the former subsumed into the "people", the latter into its other.
(9) Tilting sloths anesthetized with chloralose from erect to supine or supine to erect produced little or no effect on heart rate.
(10) Sloth fat cells showed a very low glucose oxidation to 14CO2 and incorporation into total lipids.
(11) Acute, fatal infections with this parasite are also recorded in a number of captive "coatimundis", Nasua narica (Carnivora: Procyonidae) and a sloth, Bradypus tridactylus (Edentata).
(12) The cellular composition and relative frequency of the occurrence of pancreatic endocrine cells were studied immunohistochemically in a primitive eutherian and arboreal folivore, the three-toed sloth, since previous histochemical and ultrastructural studies on the endocrine pancreas of the sloth have detected only a single islet cell type, the A cell.
(13) The intestinal of the 3-toed sloth, Bradypus tridactylus, was studied macroscopically, with light microscope and with histochemical methods for mucosubstances.
(14) 8.50pm BST 48 min: Dortmund have started with the same zip that they started the first half - and Bayern with the same sloth.
(15) Leishmania (Viannia) shawi Lainson, Braga, de Souza, Póvoa, Ishikawa & Silveira, 1989, was originally recorded from monkeys (Cebus apella and Chiropotes satanas), sloths (Choloepus didactylus and Bradypus tridactylus) and coatis (Nasua nasua) and the sandfly, Lutzomyia whitmani.
(16) Rincón lists his most significant findings with the contagious enthusiasm of a child reciting the cast of the Ice Age movies: the giant femur of a six-tonne mastodon, a giant ground sloth, a 10-ft pelican, caimans the size of buses and the almost intact skull of a sabre-toothed tiger.
(17) Like a stern housekeeper, he has roamed from floor to floor in government buildings, casting disapproving glances at the litter, the sloth and the lack of discipline.
(18) Since it has been reported that sloths have a very low rate on thyroxine secretion, the results are discussed in relation to data in the literature on carbohydrate and lipid metabolism in hypothyroid animals.
(19) A s a fashion accessory, the beard occupies the sweet spot where sloth meets affectation – that’s why I’ve got one – although you couldn’t really call facial hair fashionable any more.
(20) He moved with the bounce of a sloth, served meekly and lacked any of the vim that had carried him this far.