(1) An insulin response element (IRE) has been identified in the prolactin gene using chimeric plasmids in which prolactin promoter DNA directs expression of the bacterial chloramphenicol acetyltransferase gene.
(2) The lability of the Fe-S cluster in mitochondrial aconitase has led us to propose that the mechanism by which iron levels are sensed by the IRE-BP involves changes in an Fe-S cluster in the IRE-BP.
(3) Government officials drew the public’s ire after charging Manning with three counts of misconduct following the suicide attempt, including two which carried possible penalties of indefinite solitary confinement.
(4) In a prospective, blinded trial, 40 healthy adult subjects using six IRED thermometers with two techniques were examined in random sequence.
(5) On Wednesday, the ire of the marchers was focused on all those Lib Dems who blithely signed the NUS's anti-fees pledge ("I pledge to vote against any increase in fees in the next parliament and to pressure the government to introduce a fairer alternative" – yesterday, Nick Clegg limply said that he "should have been more careful" than to put his name to it).
(6) Oleg Sentsov should make new films, not count years in prison.” Facebook Twitter Pinterest Oleg Sentsov sings the Ukrainian national anthem as he is sentenced to 20 years in a Russian penal colony Sentsov attracted the ire of the Russian authorities after helping to organise a campaign protesting at Russia’s occupation and annexation of Crimea in March 2014.
(7) A deletion and reconstitution study was undertaken to address the possibility that regions of the ferritin gene and mRNA other than the IRE may be necessary for the production of the full range of iron regulation.
(8) Her predecessor, Nick Robinson, attracted similar ire by upsetting Scottish nationalists .
(9) Interestingly, the FRP which remains active at a given hemin concentration binds to the IRE with the same high affinity as untreated FRP.
(10) The results strongly suggest that HCV RNA carries an internal ribosome entry site (IRES).
(11) Among the 17 pancreatic cancer patients with elevated IRE, 10 underwent radical resection of the cancer but in none of the five patients with normal serum IRE could radical resection be carried out.
(12) In addition, a poor sequence context around AUG-11 results in increased initiation at one or more downstream AUG codons, indicative of leaky scanning or jumping by the ribosome from AUG-11 mediated by the EMCV IRES.
(13) Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase.
(14) Regulation in both instances is mediated by binding of a cytosolic protein to the IREs.
(15) Binding of the IRE-BP represses ferritin translation and represses degradation of the TfR mRNA.
(16) Yet in doing so it presents an angled mirror-polished cliff face of glass, which has been reflecting the sun straight across into the Lloyds offices across the road – the seminal "inside-out" machine that Rogers designed 30 years earlier – much to the ire of its tenants.
(17) The nations with the highest recorded levels include Colombia, Uganda, Afghanistan, India, Pakistan, Bangladesh and Nepal, with the south Asian countries in particular producing unforgettable images of disfigured women who have been assaulted with acid because they have rejected sexual advances or marriage proposals, or aroused jealousy, or in some way or other inconvenienced the patriarchy and aroused its ire.
(18) Artificial mono- and dicistronic mRNAs were prepared and used to identify the region that carried the IRES.
(19) Two melanotic human melanoma cell lines, IRE 1 and IRE 2, and the lymphoma- and leukaemia-derived cell lines Raji and K 562, were exposed to different concentrations (from 5 X 10(-3) M to 10(-5) M) of phenols, both substrates (s) and non-substrates (ns) of tyrosinase, in the presence or absence of the oxygen-radical-scavenger enzymes superoxide dismutase, catalase and peroxidase.
(20) Afterwards, she was "suddenly beautiful", and though the attention this brought was occasionally useful, mostly it was just a pain in the butt: the tiresome suggestions that she had only got on thanks to her appearance; the hurtful ire of that other great feminist, Betty Friedan, whose loathing of Steinem seemed mostly to be motivated by envy.
Keen
Definition:
(superl.) Sharp; having a fine edge or point; as, a keen razor, or a razor with a keen edge.
(superl.) Acute of mind; sharp; penetrating; having or expressing mental acuteness; as, a man of keen understanding; a keen look; keen features.
(superl.) Piercing; penetrating; cutting; sharp; -- applied to cold, wind, etc, ; as, a keen wind; the cold is very keen.
(superl.) Eager; vehement; fierce; as, a keen appetite.
(v. t.) To sharpen; to make cold.
(n.) A prolonged wail for a deceased person. Cf. Coranach.
(v. i.) To wail as a keener does.
Example Sentences:
(1) That the BBC has probably not been as vulnerable since the 1980s is also true – not least because the enemies of impartiality are more powerful, and the BBC's competitors (maimed after a year's exposure of their own behaviour in the Leveson inquiry ) are keen to wreck it.
(2) It has me as a listener and I am keen as well on sciences, arts, geography, history and politics, and I belong to two campaigns in Brighton and Chichester against privatisation of the NHS, and with some successes.
(3) Theresa May to visit India in signal of trading priorities post-Brexit Read more Cable said India had been keen to expand “ Mode 4 ” market access: the ability to bring in staff – Indian IT experts, for example – as part of trading in services.
(4) As corruption consistently ranks as a top concern for Spaniards, second only to unemployment, and with an eye on upcoming municipal and regional elections in the spring, Spain’s political parties have been keen to appear as if they are tackling the issue.
(5) He is understood to be keen to remain in the London area.
(6) The tech workers are mostly well-paid and keen to live downtown.
(7) Some Labour MPs, such as Frank Field and David Miliband, are keen on primaries.
(8) Professor Androsov was extremely hospitable and showed a keen interest in the freer exchange of knowledge between American and Soviet surgeons.
(9) The government, too, is keen to strike a conciliatory note, at least compared with the strident tones of the Iron Lady's day.
(10) Photograph: Peter Beaumont for the Guardian For his part the leader of Hadash, the veteran socialist party in Israel that emphasises Arab-Jewish cooperation, Odeh has now attracted a political star status most obvious on the stump in Lod on Wednesday in the repeated cries of “Ayman!” by shopkeepers and passersby keen to shake his hand or be photographed with him.
(11) This seemed contradictory for a government keen on getting people out of their cars, and given that at the time the Treasury finances were relatively healthy.
(12) Palaszczuk said she was keen to use her first attendance at a Coag meeting to push for the federal government to “accelerate some of their money towards the states” for the national disability insurance scheme.
(13) Even more striking is the stance being adopted by Hagan and her Democratic supporters, who have been as keen to discuss social issues as the Republicans have been to avoid them.
(14) Britain's estate agents today report a surge in the number of properties for sale amid signs jittery vendors are keen to strike a deal before next month's general election.
(15) It is a game to spend two hours together and enjoy our time together and say: ‘I was happy.’” Guardiola, who will be joined by the former Arsenal and Everton midfielder Mikel Arteta on his coaching staff , is keen to promote players from City’s junior ranks.
(16) May is thought to have been keen to examine more closely the role of Chinese companies in the project amid concerns about the impact on national security and despite her predecessor David Cameron’s strong support for Hinkley .
(17) Ian Livingstone is not all that keen on being photographed near the life-sized model of Lara Croft in his study – even though he was largely responsible for launching her on the world nearly 20 years ago, and the heroine of the Tomb Raider video games, comics and films helped to make his fortune.
(18) We were very keen to preserve the silhouette of the Leadenhall building [Cheesegrater],” says Richards.
(19) The Russians are also keen on it.” A Trump adviser confirmed the president-elect’s intention to meet Putin very soon and said that Reykjavik was under active consideration.
(20) At the same time, he is keen to do everything in his power to help Palace pick up three crucial points, right down to giving Pulis chapter and verse on the Cardiff players he knows inside out.