(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.
Malicious
Definition:
(a.) Indulging or exercising malice; harboring ill will or enmity.
(a.) Proceeding from hatred or ill will; dictated by malice; as, a malicious report; malicious mischief.
(a.) With wicked or mischievous intentions or motives; wrongful and done intentionally without just cause or excuse; as, a malicious act.
Example Sentences:
(1) Already in 2014, Proofpoint found a 650% increase in social media spam compared to 2013, and 99% of malicious URLs in inappropriate content led to malware installation or credential phishing sites,” explains the company.
(2) Rather, it is those who use OSINT as a starting point for more malicious means.
(3) Those who say otherwise, he said, “have malicious intentions to damage the Chinese government in the name of birth control.” Family planning policy would be relaxed further over time, but the government had no timetable in mind.
(4) It's worth remembering that as the US and UK run around the world protesting the hacking activities of others and warning of the dangers of cyber-attacks , that duo is one of the most aggressive and malicious, if not the most aggressive and malicious, perpetrators of those attacks of anyone on the planet.
(5) The force said: “Leicestershire police is investigating a report of malicious communication being sent via social media.
(6) In response, the EU commission’s vice president, Frans Timmersmans, condemned Orban’s questionnaire as “malicious and wrong”.
(7) Anyone who opened the file risked being infected, as many anti-virus systems were not able to detect the malicious software, the researchers said.
(8) Prosecutions under the Malicious Communications Act have resulted in convictions, as in the case involving death threats tweeted at Caroline Criado-Perez .
(9) Instead of dropping banners, as Brotherston’s ISP did, it injects malicious JavaScript.
(10) And of course, if the software that infects your machine is malicious, there's the serious risk of identity theft.
(11) China bans major shareholders from selling their stakes for next six months Read more Police and regulators are investigating evidence of potential “malicious” short selling of Chinese shares, state news agency Xinhua reported.
(12) The Conservatives won their malicious campaign against Labour in the general election, ruthlessly demonising Ed Miliband and fanning anti-Scottish resentment.
(13) Justice Department representatives told one congressional aide that Swartz' Guerilla Open Access Manifesto was being used to establish "malicious intent" to illegally download large amounts of documents.
(14) "I took out nasty passages about people I admire – like Polly Toynbee, George Monbiot, Deborah Orr and Yasmin Alibhai-Brown … but in a few instances, I edited the entries of people I had clashed with in ways that were juvenile or malicious: I called one of them antisemitic and homophobic, and the other a drunk."
(15) Frances Knox, 44, from Hertfordshire, has resolved to change her passwords every month after she had her Skype account maliciously taken over by fraudsters on 21 December.
(16) Any suggestion of impropriety is malicious and defamatory and will be treated as such,” said a spokesman.
(17) The 'Sorry' campaign's suggestion that the Standard and its journalists lost touch with London is a malicious invention.
(18) We have identified this as a new and growing threat in the UK and you just have to look at the figures – in fact 51% of the malicious software threats that have ever been identified were in 2009."
(19) We are left to conclude that the purpose is a malicious one.
(20) The UK's biggest retailer began legal proceedings against the paper and its editor, Alan Rusbridger, for libel and malicious falsehood.